5MM6

Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL H 301

Chain	Residue
H	ARG93
H	ARG165
H	ILE176
H	THR177
H	ASP178
H	PO4306
H	HOH467
H	HOH563

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL H 302

Chain	Residue
H	ARG165
H	ASP178
H	HIS230
H	HOH413
H	ARG93

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL H 303

Chain	Residue
H	ARG93
H	ASN95
H	PO4306
H	HOH408

---

site_id	AC4
Number of Residues	4
Details	binding site for residue DMS H 304

Chain	Residue
H	LEU130
H	ARG165
H	PHE181
H	HOH455

---

site_id	AC5
Number of Residues	4
Details	binding site for residue DMS H 305

Chain	Residue
H	PHE204
H	GLY223
H	LYS224
H	HOH401

---

site_id	AC6
Number of Residues	9
Details	binding site for residue PO4 H 306

Chain	Residue
H	ASN95
H	ASP100
H	ARG101
H	ARG175
H	GOL301
H	GOL303
H	HOH402
H	HOH428
H	HOH583

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL H 307

Chain	Residue
H	ARG173
H	PHE204
H	HOH416
H	HOH590

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA H 308

Chain	Residue
H	ARG221
H	LYS224
H	HOH461
H	HOH476
H	HOH501
H	HOH564

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NA H 309

Chain	Residue
H	LYS169
H	THR172
H	PHE204
H	HOH469
H	HOH470
H	HOH569

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL H 310

Chain	Residue
H	LEU41
H	CYS42
H	TRP60
H	GLU192
H	GLY193
H	SER195
H	32U311

---

site_id	AD2
Number of Residues	18
Details	binding site for residue 32U H 311

Chain	Residue
H	HIS57
H	TYR60
H	GLU97
H	ASP189
H	SER190
H	GLU192
H	SER195
H	VAL213
H	SER214
H	TRP215
H	GLY216
H	GLY219
H	GLY226
H	GOL310
H	HOH462
H	HOH492
H	HOH533
H	HOH549

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---