5MM0
Dolichyl phosphate mannose synthase in complex with GDP-mannose and Mn2+ (donor complex)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004582 | molecular_function | dolichyl-phosphate beta-D-mannosyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006486 | biological_process | obsolete protein glycosylation |
| A | 0006488 | biological_process | dolichol-linked oligosaccharide biosynthetic process |
| A | 0006506 | biological_process | GPI anchor biosynthetic process |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0009101 | biological_process | glycoprotein biosynthetic process |
| A | 0009247 | biological_process | glycolipid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0035269 | biological_process | protein O-linked glycosylation via mannose |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0180047 | biological_process | dolichol phosphate mannose biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue GDD A 401 |
| Chain | Residue |
| A | PRO8 |
| A | ALA90 |
| A | ASP91 |
| A | GLN93 |
| A | HIS94 |
| A | ARG117 |
| A | VAL156 |
| A | GLY158 |
| A | LYS178 |
| A | ARG202 |
| A | SER207 |
| A | THR9 |
| A | LYS208 |
| A | MN402 |
| A | TYR10 |
| A | GLU12 |
| A | VAL37 |
| A | ASP39 |
| A | LEU69 |
| A | ALA72 |
| A | ASP89 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 402 |
| Chain | Residue |
| A | ASP91 |
| A | GLN93 |
| A | ARG202 |
| A | GDD401 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 403 |
| Chain | Residue |
| A | ASN277 |
| A | PHE301 |
| A | ARG341 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue LDA A 404 |
| Chain | Residue |
| A | SER243 |
| A | TRP280 |
| A | TRP284 |
| A | LDA407 |
| A | LDA407 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue LDA A 405 |
| Chain | Residue |
| A | LEU242 |
| A | ILE245 |
| A | GLU249 |
| A | GLY250 |
| A | PHE251 |
| A | TRP253 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue LDA A 406 |
| Chain | Residue |
| A | ARG150 |
| A | HIS347 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue LDA A 407 |
| Chain | Residue |
| A | PHE279 |
| A | TRP284 |
| A | LDA404 |
| A | LDA404 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue LDA A 408 |
| Chain | Residue |
| A | VAL270 |
| A | SER273 |
| A | LEU306 |
| A | LEU306 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 235 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28743912","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MLZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MM0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
