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5MKZ

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one

Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue RNK A 201
ChainResidue
ATRP81
APRO82
APHE83
AVAL87
AASN140
AILE146
AHOH312
AHOH457

site_idAC2
Number of Residues10
Detailsbinding site for residue GOL A 202
ChainResidue
ALYS76
ATHR134
ATYR137
AGLU154
ALEU156
AGLN159
ALYS160
AGOL203
AHOH358
ATHR73

site_idAC3
Number of Residues9
Detailsbinding site for residue GOL A 203
ChainResidue
AARG68
AVAL69
ALYS72
ATHR73
ALYS76
ATYR137
AGLU151
AGOL202
AHOH461

site_idAC4
Number of Residues9
Detailsbinding site for residue GOL A 204
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AILE138
AHOH411
AHOH423
AHOH473

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

221051

PDB entries from 2024-06-12

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