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5MKZ

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one

Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue RNK A 201
ChainResidue
ATRP81
APRO82
APHE83
AVAL87
AASN140
AILE146
AHOH312
AHOH457

site_idAC2
Number of Residues10
Detailsbinding site for residue GOL A 202
ChainResidue
ALYS76
ATHR134
ATYR137
AGLU154
ALEU156
AGLN159
ALYS160
AGOL203
AHOH358
ATHR73

site_idAC3
Number of Residues9
Detailsbinding site for residue GOL A 203
ChainResidue
AARG68
AVAL69
ALYS72
ATHR73
ALYS76
ATYR137
AGLU151
AGOL202
AHOH461

site_idAC4
Number of Residues9
Detailsbinding site for residue GOL A 204
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AILE138
AHOH411
AHOH423
AHOH473

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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