5MKV

Crystal Structure of Human Dihydropyrimidinease-like 2 (DPYSL2A)/Collapsin Response Mediator Protein (CRMP2) residues 13-516

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0005737	cellular_component	cytoplasm
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0005737	cellular_component	cytoplasm
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0005737	cellular_component	cytoplasm
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue EDO A 601

Chain	Residue
A	LYS254
A	GLU353
A	EDO606
A	HOH800

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 602

Chain	Residue
A	HOH728
A	ASN426
A	LEU454
A	GLY457
A	EDO603
A	HOH713

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 603

Chain	Residue
A	GLU359
A	THR424
A	EDO602
A	HOH713

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 604

Chain	Residue
A	VAL109
A	PRO110
A	GLU111
A	THR114
A	ALA119

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 605

Chain	Residue
A	ARG268
A	THR272
A	ARG481
B	SER322
B	CYS323

---

site_id	AC6
Number of Residues	10
Details	binding site for residue EDO A 606

Chain	Residue
A	ILE279
A	THR303
A	SER331
A	ALA332
A	CYS334
A	GLY354
A	THR355
A	EDO601
A	HOH710
A	HOH799

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 607

Chain	Residue
A	ARG268
A	TYR275
A	GLN327
A	PHE477
A	ARG481
A	HOH775
A	HOH822

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 608

Chain	Residue
A	TRP295
A	LYS345
C	LYS423
C	ARG496
C	GLY497
C	LEU498
C	TYR499

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 609

Chain	Residue
A	LYS345
C	TYR431
C	TYR499

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 610

Chain	Residue
A	ASP27
A	ASP376
A	GLN379
A	HOH716
B	PHE477

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 611

Chain	Residue
A	ASP476
A	LYS480
B	LYS23

---

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO B 601

Chain	Residue
B	HOH701
B	HOH703

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO B 602

Chain	Residue
A	SER30
A	GLU377
B	ASP476
B	LYS480
B	HOH702

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO B 603

Chain	Residue
B	ARG268
B	VAL274
B	TYR275
B	GLN327
B	ARG481

---

site_id	AD6
Number of Residues	9
Details	binding site for residue EDO B 604

Chain	Residue
B	ALA95
B	HIS333
B	ASN356
B	GLU359
B	GLU360
B	HIS425
B	SER427
B	ASN432
B	HOH724

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO C 601

Chain	Residue
C	ARG268
C	THR272
C	ARG481
D	HOH759

---

site_id	AD8
Number of Residues	1
Details	binding site for residue EDO D 601

Chain	Residue
D	HOH803

---

site_id	AD9
Number of Residues	2
Details	binding site for residue EDO D 602

Chain	Residue
D	ILE401
D	ALA402

---

site_id	AE1
Number of Residues	5
Details	binding site for residue EDO D 603

Chain	Residue
D	ASP27
D	ASN378
D	GLN379
D	ALA382
D	HOH819

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO D 604

Chain	Residue
D	MET64
D	TRP366
D	GLU377
D	PRO414

---

site_id	AE3
Number of Residues	3
Details	binding site for residue EDO D 605

Chain	Residue
D	ASN426
D	LEU454
D	GLY457

---

site_id	AE4
Number of Residues	8
Details	binding site for residue EDO D 606

Chain	Residue
D	HIS333
D	ASN356
D	GLU359
D	GLU360
D	HIS425
D	ASN432
D	HOH703
D	HOH707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by FYN","evidences":[{"source":"PubMed","id":"19652227","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P47942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08553","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P47942","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---