5MJT

Thrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 23U H 301

Chain	Residue
H	HIS57
H	TRP215
H	GLY216
H	GLY219
H	PHE227
H	GOL310
H	HOH401
H	HOH466
L	GLY16
H	TYR60
H	TRP60
H	GLU97
H	LEU99
H	SER190
H	SER195
H	VAL213
H	SER214

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site_id	AC2
Number of Residues	4
Details	binding site for residue DMS H 302

Chain	Residue
H	LEU130
H	ARG165
H	PHE181
H	HOH450

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site_id	AC3
Number of Residues	9
Details	binding site for residue PO4 H 303

Chain	Residue
H	ASN95
H	ASP100
H	ARG101
H	ARG175
H	GOL304
H	GOL306
H	HOH416
H	HOH419
H	HOH441

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL H 304

Chain	Residue
H	PRO92
H	ARG93
H	ASN95
H	PO4303
H	HOH467

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL H 305

Chain	Residue
H	SER171
H	THR172
H	TRP215
H	GLY216
H	GLU217
H	LYS224
H	TYR225
H	PHE227

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL H 306

Chain	Residue
H	ARG93
H	ARG165
H	ILE176
H	THR177
H	ASP178
H	PO4303
H	HOH443

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL H 307

Chain	Residue
H	ARG93
H	ARG165
H	ASP178
H	HIS230
H	HOH444

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA H 308

Chain	Residue
H	ARG221
H	LYS224
H	HOH481
H	HOH486
H	HOH487
H	HOH551

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NA H 309

Chain	Residue
H	LYS169
H	THR172
H	PHE204
H	HOH491
H	HOH493
H	HOH558

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL H 310

Chain	Residue
H	LEU41
H	CYS42
H	TRP60
H	GLU192
H	GLY193
H	SER195
H	23U301
H	HOH401

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:3513162

Chain	Residue	Details
D	TYS526
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
H	ASN60

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