Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MJS

S. pombe microtubule copolymerized with GTP and Mal3-143

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000022	biological_process	mitotic spindle elongation
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000235	cellular_component	astral microtubule
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005876	cellular_component	spindle microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0007017	biological_process	microtubule-based process
A	0007052	biological_process	mitotic spindle organization
A	0015630	cellular_component	microtubule cytoskeleton
A	0031122	biological_process	cytoplasmic microtubule organization
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0048312	biological_process	intracellular distribution of mitochondria
A	0097435	biological_process	supramolecular fiber organization
A	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
A	1903087	biological_process	mitotic spindle pole body duplication
B	0000022	biological_process	mitotic spindle elongation
B	0000070	biological_process	mitotic sister chromatid segregation
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000235	cellular_component	astral microtubule
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005876	cellular_component	spindle microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0007017	biological_process	microtubule-based process
B	0007052	biological_process	mitotic spindle organization
B	0015630	cellular_component	microtubule cytoskeleton
B	0031122	biological_process	cytoplasmic microtubule organization
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0048312	biological_process	intracellular distribution of mitochondria
B	0097435	biological_process	supramolecular fiber organization
B	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
B	1903087	biological_process	mitotic spindle pole body duplication
C	0000022	biological_process	mitotic spindle elongation
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000235	cellular_component	astral microtubule
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005876	cellular_component	spindle microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0007017	biological_process	microtubule-based process
C	0007052	biological_process	mitotic spindle organization
C	0015630	cellular_component	microtubule cytoskeleton
C	0031122	biological_process	cytoplasmic microtubule organization
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0048312	biological_process	intracellular distribution of mitochondria
C	0097435	biological_process	supramolecular fiber organization
C	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
C	1903087	biological_process	mitotic spindle pole body duplication
D	0008017	molecular_function	microtubule binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000235	cellular_component	astral microtubule
E	0000278	biological_process	mitotic cell cycle
E	0000280	biological_process	nuclear division
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005819	cellular_component	spindle
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000235	cellular_component	astral microtubule
F	0000278	biological_process	mitotic cell cycle
F	0000280	biological_process	nuclear division
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005819	cellular_component	spindle
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
F	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000235	cellular_component	astral microtubule
G	0000278	biological_process	mitotic cell cycle
G	0000280	biological_process	nuclear division
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005819	cellular_component	spindle
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0016787	molecular_function	hydrolase activity
G	0046872	molecular_function	metal ion binding
G	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000235	cellular_component	astral microtubule
H	0000278	biological_process	mitotic cell cycle
H	0000280	biological_process	nuclear division
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005819	cellular_component	spindle
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0016787	molecular_function	hydrolase activity
H	0046872	molecular_function	metal ion binding
H	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
J	0000022	biological_process	mitotic spindle elongation
J	0000070	biological_process	mitotic sister chromatid segregation
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000235	cellular_component	astral microtubule
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005876	cellular_component	spindle microtubule
J	0005881	cellular_component	cytoplasmic microtubule
J	0007017	biological_process	microtubule-based process
J	0007052	biological_process	mitotic spindle organization
J	0015630	cellular_component	microtubule cytoskeleton
J	0031122	biological_process	cytoplasmic microtubule organization
J	0046677	biological_process	response to antibiotic
J	0046872	molecular_function	metal ion binding
J	0048312	biological_process	intracellular distribution of mitochondria
J	0097435	biological_process	supramolecular fiber organization
J	0098863	biological_process	nuclear migration by microtubule mediated pushing forces
J	1903087	biological_process	mitotic spindle pole body duplication

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue GDP A 500

Chain	Residue
A	GLY10
A	GLY144
A	ASP177
A	ASN204
A	TYR222
A	ASN226
F	LEU252
A	GLN11
A	CYS12
A	ASN99
A	SER138
A	GLY140
A	GLY141
A	GLY142
A	THR143

site_id	AC2
Number of Residues	16
Details	binding site for residue GTP E 500

Chain	Residue
E	GLY10
E	GLN11
E	ALA12
E	GLN15
E	ASP73
E	SER104
E	SER144
E	GLY146
E	GLY147
E	GLY148
E	THR149
E	GLY150
E	THR183
E	ASN210
E	TYR228
E	ASN232

site_id	AC3
Number of Residues	15
Details	binding site for residue GTP F 500

Chain	Residue
F	GLY10
F	GLN11
F	ALA12
F	GLN15
F	SER104
F	GLY146
F	GLY147
F	GLY148
F	THR149
F	GLY150
F	THR183
F	GLU187
F	ASN210
F	TYR228
F	ASN232

site_id	AC4
Number of Residues	15
Details	binding site for residue GTP G 500

Chain	Residue
G	GLY10
G	GLN11
G	ALA12
G	GLN15
G	SER104
G	ASN105
G	GLY146
G	GLY147
G	GLY148
G	THR149
G	GLY150
G	THR183
G	ASN210
G	TYR228
G	ASN232

site_id	AC5
Number of Residues	16
Details	binding site for residue GTP H 500

Chain	Residue
H	GLY10
H	GLN11
H	ALA12
H	GLN15
H	SER104
H	ASN105
H	GLY146
H	GLY147
H	GLY148
H	THR149
H	GLY150
H	THR183
H	GLU187
H	ASN210
H	TYR228
H	ASN232

site_id	AC6
Number of Residues	14
Details	binding site for residue GDP J 500

Chain	Residue
E	LEU252
J	GLY10
J	GLN11
J	CYS12
J	ASN99
J	SER138
J	GLY140
J	GLY141
J	GLY142
J	THR143
J	GLY144
J	ASP177
J	TYR222
J	ASN226

site_id	AC7
Number of Residues	15
Details	binding site for residue GDP B 500

Chain	Residue
B	THR143
B	GLY144
B	SER145
B	ASP177
B	ASN204
B	TYR222
B	ASN226
B	GLY10
B	GLN11
B	CYS12
B	ASN99
B	SER138
B	GLY140
B	GLY141
B	GLY142

site_id	AC8
Number of Residues	14
Details	binding site for residue GDP C 500

Chain	Residue
C	GLY10
C	GLN11
C	CYS12
C	ASN99
C	SER138
C	GLY141
C	GLY142
C	THR143
C	GLY144
C	SER145
C	ASP177
C	ASN204
C	TYR222
C	ASN226

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
E	GLY146-GLY152
A	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
A	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	101
Details	Domain: {"description":"Calponin-homology (CH)","evidences":[{"source":"PROSITE-ProRule","id":"PRU00044","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)