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5MJS

S. pombe microtubule copolymerized with GTP and Mal3-143

Functional Information from GO Data
ChainGOidnamespacecontents
A0000022biological_processmitotic spindle elongation
A0000226biological_processmicrotubule cytoskeleton organization
A0000235cellular_componentastral microtubule
A0000278biological_processmitotic cell cycle
A0003924molecular_functionGTPase activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005876cellular_componentspindle microtubule
A0005881cellular_componentcytoplasmic microtubule
A0007017biological_processmicrotubule-based process
A0031122biological_processcytoplasmic microtubule organization
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
A0048312biological_processintracellular distribution of mitochondria
A0098863biological_processnuclear migration by microtubule mediated pushing forces
A1903087biological_processmitotic spindle pole body duplication
B0000022biological_processmitotic spindle elongation
B0000226biological_processmicrotubule cytoskeleton organization
B0000235cellular_componentastral microtubule
B0000278biological_processmitotic cell cycle
B0003924molecular_functionGTPase activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005876cellular_componentspindle microtubule
B0005881cellular_componentcytoplasmic microtubule
B0007017biological_processmicrotubule-based process
B0031122biological_processcytoplasmic microtubule organization
B0046677biological_processresponse to antibiotic
B0046872molecular_functionmetal ion binding
B0048312biological_processintracellular distribution of mitochondria
B0098863biological_processnuclear migration by microtubule mediated pushing forces
B1903087biological_processmitotic spindle pole body duplication
C0000022biological_processmitotic spindle elongation
C0000226biological_processmicrotubule cytoskeleton organization
C0000235cellular_componentastral microtubule
C0000278biological_processmitotic cell cycle
C0003924molecular_functionGTPase activity
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005876cellular_componentspindle microtubule
C0005881cellular_componentcytoplasmic microtubule
C0007017biological_processmicrotubule-based process
C0031122biological_processcytoplasmic microtubule organization
C0046677biological_processresponse to antibiotic
C0046872molecular_functionmetal ion binding
C0048312biological_processintracellular distribution of mitochondria
C0098863biological_processnuclear migration by microtubule mediated pushing forces
C1903087biological_processmitotic spindle pole body duplication
D0008017molecular_functionmicrotubule binding
E0000226biological_processmicrotubule cytoskeleton organization
E0000235cellular_componentastral microtubule
E0000278biological_processmitotic cell cycle
E0000280biological_processnuclear division
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005819cellular_componentspindle
E0005856cellular_componentcytoskeleton
E0005874cellular_componentmicrotubule
E0007017biological_processmicrotubule-based process
E0016787molecular_functionhydrolase activity
E0046872molecular_functionmetal ion binding
E0098863biological_processnuclear migration by microtubule mediated pushing forces
F0000226biological_processmicrotubule cytoskeleton organization
F0000235cellular_componentastral microtubule
F0000278biological_processmitotic cell cycle
F0000280biological_processnuclear division
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005819cellular_componentspindle
F0005856cellular_componentcytoskeleton
F0005874cellular_componentmicrotubule
F0007017biological_processmicrotubule-based process
F0016787molecular_functionhydrolase activity
F0046872molecular_functionmetal ion binding
F0098863biological_processnuclear migration by microtubule mediated pushing forces
G0000226biological_processmicrotubule cytoskeleton organization
G0000235cellular_componentastral microtubule
G0000278biological_processmitotic cell cycle
G0000280biological_processnuclear division
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005819cellular_componentspindle
G0005856cellular_componentcytoskeleton
G0005874cellular_componentmicrotubule
G0007017biological_processmicrotubule-based process
G0016787molecular_functionhydrolase activity
G0046872molecular_functionmetal ion binding
G0098863biological_processnuclear migration by microtubule mediated pushing forces
H0000226biological_processmicrotubule cytoskeleton organization
H0000235cellular_componentastral microtubule
H0000278biological_processmitotic cell cycle
H0000280biological_processnuclear division
H0005200molecular_functionstructural constituent of cytoskeleton
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005819cellular_componentspindle
H0005856cellular_componentcytoskeleton
H0005874cellular_componentmicrotubule
H0007017biological_processmicrotubule-based process
H0016787molecular_functionhydrolase activity
H0046872molecular_functionmetal ion binding
H0098863biological_processnuclear migration by microtubule mediated pushing forces
J0000022biological_processmitotic spindle elongation
J0000226biological_processmicrotubule cytoskeleton organization
J0000235cellular_componentastral microtubule
J0000278biological_processmitotic cell cycle
J0003924molecular_functionGTPase activity
J0005200molecular_functionstructural constituent of cytoskeleton
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005874cellular_componentmicrotubule
J0005876cellular_componentspindle microtubule
J0005881cellular_componentcytoplasmic microtubule
J0007017biological_processmicrotubule-based process
J0031122biological_processcytoplasmic microtubule organization
J0046677biological_processresponse to antibiotic
J0046872molecular_functionmetal ion binding
J0048312biological_processintracellular distribution of mitochondria
J0098863biological_processnuclear migration by microtubule mediated pushing forces
J1903087biological_processmitotic spindle pole body duplication
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue GDP A 500
ChainResidue
AGLY10
AGLY144
AASP177
AASN204
ATYR222
AASN226
FLEU252
AGLN11
ACYS12
AASN99
ASER138
AGLY140
AGLY141
AGLY142
ATHR143

site_idAC2
Number of Residues16
Detailsbinding site for residue GTP E 500
ChainResidue
EGLY10
EGLN11
EALA12
EGLN15
EASP73
ESER104
ESER144
EGLY146
EGLY147
EGLY148
ETHR149
EGLY150
ETHR183
EASN210
ETYR228
EASN232

site_idAC3
Number of Residues15
Detailsbinding site for residue GTP F 500
ChainResidue
FGLY10
FGLN11
FALA12
FGLN15
FSER104
FGLY146
FGLY147
FGLY148
FTHR149
FGLY150
FTHR183
FGLU187
FASN210
FTYR228
FASN232

site_idAC4
Number of Residues15
Detailsbinding site for residue GTP G 500
ChainResidue
GGLY10
GGLN11
GALA12
GGLN15
GSER104
GASN105
GGLY146
GGLY147
GGLY148
GTHR149
GGLY150
GTHR183
GASN210
GTYR228
GASN232

site_idAC5
Number of Residues16
Detailsbinding site for residue GTP H 500
ChainResidue
HGLY10
HGLN11
HALA12
HGLN15
HSER104
HASN105
HGLY146
HGLY147
HGLY148
HTHR149
HGLY150
HTHR183
HGLU187
HASN210
HTYR228
HASN232

site_idAC6
Number of Residues14
Detailsbinding site for residue GDP J 500
ChainResidue
ELEU252
JGLY10
JGLN11
JCYS12
JASN99
JSER138
JGLY140
JGLY141
JGLY142
JTHR143
JGLY144
JASP177
JTYR222
JASN226

site_idAC7
Number of Residues15
Detailsbinding site for residue GDP B 500
ChainResidue
BTHR143
BGLY144
BSER145
BASP177
BASN204
BTYR222
BASN226
BGLY10
BGLN11
BCYS12
BASN99
BSER138
BGLY140
BGLY141
BGLY142

site_idAC8
Number of Residues14
Detailsbinding site for residue GDP C 500
ChainResidue
CGLY10
CGLN11
CCYS12
CASN99
CSER138
CGLY141
CGLY142
CTHR143
CGLY144
CSER145
CASP177
CASN204
CTYR222
CASN226

Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
AGLY140-GLY146
EGLY146-GLY152

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
AMET1-ILE4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P68363
ChainResidueDetails
EGLU258
JGLY142
JTHR143
JGLY144
JASN204
JASN226
BGLN11
BSER138
BGLY142
BTHR143
BGLY144
FGLU258
BASN204
BASN226
CGLN11
CSER138
CGLY142
CTHR143
CGLY144
CASN204
CASN226
GGLU258
HGLU258
AGLY144
AASN204
AASN226
JGLN11
JSER138

site_idSWS_FT_FI2
Number of Residues32
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P68363
ChainResidueDetails
EGLN11
FGLU75
FSER144
FGLY148
FTHR149
FTHR183
FASN210
FASN232
GGLN11
GGLU75
GSER144
EGLU75
GGLY148
GTHR149
GTHR183
GASN210
GASN232
HGLN11
HGLU75
HSER144
HGLY148
HTHR149
ESER144
HTHR183
HASN210
HASN232
EGLY148
ETHR149
ETHR183
EASN210
EASN232
FGLN11

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PDB entries from 2024-11-06

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