5MJK

Crystal Structure of Lactococcus lactis Thioredoxin Reductase (FO conformation)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0045454	biological_process	cell redox homeostasis
B	0000166	molecular_function	nucleotide binding
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0045454	biological_process	cell redox homeostasis
C	0000166	molecular_function	nucleotide binding
C	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0045454	biological_process	cell redox homeostasis
D	0000166	molecular_function	nucleotide binding
D	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue FAD A 401

Chain	Residue
A	GLY12
A	THR46
A	ASN51
A	GLY81
A	VAL83
A	ALA110
A	THR111
A	GLY112
A	CYS137
A	VAL243
A	PHE246
A	GLY14
A	GLY276
A	ASP277
A	ARG284
A	GLN285
A	ILE286
A	ALA289
A	HOH509
A	HOH511
A	HOH519
A	HOH522
A	PRO15
A	HOH524
A	HOH528
A	HOH537
A	ALA16
A	GLU35
A	ARG36
A	GLY41
A	GLN42
A	ASN45

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 402

Chain	Residue
A	GLY153
A	ASP154
A	SER155
A	ARG180

---

site_id	AC3
Number of Residues	30
Details	binding site for residue FAD B 401

Chain	Residue
B	GLY12
B	GLY14
B	PRO15
B	ALA16
B	GLU35
B	ARG36
B	GLY41
B	GLN42
B	ASN45
B	THR46
B	ASN51
B	GLY81
B	VAL83
B	ALA110
B	THR111
B	GLY112
B	CYS137
B	VAL243
B	PHE246
B	GLY276
B	ASP277
B	ARG284
B	GLN285
B	ILE286
B	HOH513
B	HOH523
B	HOH531
B	HOH535
B	HOH544
B	HOH560

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 402

Chain	Residue
B	GLY153
B	ASP154
B	SER155
B	ARG180

---

site_id	AC5
Number of Residues	32
Details	binding site for residue FAD C 401

Chain	Residue
C	HOH535
C	HOH544
C	HOH551
C	GLY12
C	GLY14
C	PRO15
C	ALA16
C	GLU35
C	ARG36
C	GLY41
C	GLN42
C	THR46
C	ASN51
C	GLY81
C	VAL83
C	ALA110
C	THR111
C	GLY112
C	CYS137
C	VAL243
C	PHE246
C	GLY276
C	ASP277
C	ARG284
C	GLN285
C	ILE286
C	HOH511
C	HOH512
C	HOH513
C	HOH523
C	HOH528
C	HOH530

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 C 402

Chain	Residue
C	GLY153
C	ASP154
C	SER155
C	ARG180

---

site_id	AC7
Number of Residues	33
Details	binding site for residue FAD D 401

Chain	Residue
D	GLY12
D	GLY14
D	PRO15
D	ALA16
D	GLU35
D	ARG36
D	VAL38
D	GLY41
D	GLN42
D	THR46
D	ASN51
D	GLY81
D	VAL83
D	ALA110
D	THR111
D	GLY112
D	CYS137
D	VAL243
D	PHE246
D	GLY276
D	ASP277
D	ARG284
D	GLN285
D	ILE286
D	ALA289
D	HOH506
D	HOH509
D	HOH510
D	HOH518
D	HOH520
D	HOH526
D	HOH527
D	HOH528

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 D 402

Chain	Residue
D	GLY153
D	ASP154
D	SER155
D	ARG180

---

Functional Information from PROSITE/UniProt

site_id	PS00573
Number of Residues	21
Details	PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CavCDGaf..FrnqeIlVIGGGD

Chain	Residue	Details
A	CYS134-ASP154

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