5MED
Cyanothece lipoxygenase 2 (CspLOX2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| A | 0019369 | biological_process | arachidonic acid metabolic process |
| A | 0019372 | biological_process | lipoxygenase pathway |
| A | 0034440 | biological_process | lipid oxidation |
| A | 0043651 | biological_process | linoleic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050473 | molecular_function | arachidonate 15-lipoxygenase activity |
| A | 0051122 | biological_process | hepoxilin biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| B | 0019369 | biological_process | arachidonic acid metabolic process |
| B | 0019372 | biological_process | lipoxygenase pathway |
| B | 0034440 | biological_process | lipid oxidation |
| B | 0043651 | biological_process | linoleic acid metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050473 | molecular_function | arachidonate 15-lipoxygenase activity |
| B | 0051122 | biological_process | hepoxilin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 1001 |
| Chain | Residue |
| A | HIS257 |
| A | HIS262 |
| A | HIS449 |
| A | ASN453 |
| A | ILE569 |
| A | HOH1165 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue PGR A 1002 |
| Chain | Residue |
| A | GLY165 |
| A | CYS251 |
| A | BU11004 |
| A | HOH1280 |
| A | ASN162 |
| A | TYR163 |
| A | LYS164 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue BU1 A 1003 |
| Chain | Residue |
| A | PRO94 |
| A | TYR454 |
| A | CYS507 |
| A | HOH1110 |
| A | HOH1123 |
| A | HOH1432 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue BU1 A 1004 |
| Chain | Residue |
| A | ARG260 |
| A | ALA328 |
| A | ALA329 |
| A | GLU332 |
| A | PGR1002 |
| A | HOH1317 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1005 |
| Chain | Residue |
| A | PRO288 |
| A | GLN291 |
| A | PRO517 |
| A | ASP518 |
| A | HOH1103 |
| A | HOH1121 |
| A | HOH1199 |
| A | HOH1463 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue HEZ A 1006 |
| Chain | Residue |
| A | ARG57 |
| A | HIS262 |
| A | ILE296 |
| A | LEU299 |
| A | ALA300 |
| A | GLN303 |
| A | LEU304 |
| A | THR505 |
| A | LEU506 |
| A | ILE569 |
| A | HOH1165 |
| A | HOH1225 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue POL A 1007 |
| Chain | Residue |
| A | PRO395 |
| A | THR430 |
| A | ILE431 |
| A | GLU432 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue FE B 1001 |
| Chain | Residue |
| B | HIS257 |
| B | HIS262 |
| B | HIS449 |
| B | ASN453 |
| B | ILE569 |
| B | HOH1167 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue 1BO B 1002 |
| Chain | Residue |
| B | PRO94 |
| B | TYR457 |
| B | HOH1102 |
| B | HOH1110 |
| B | HOH1309 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PGR B 1003 |
| Chain | Residue |
| A | ASN425 |
| A | GLU427 |
| A | ASN429 |
| B | ARG103 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PGR B 1004 |
| Chain | Residue |
| B | ARG57 |
| B | GLN303 |
| B | LEU304 |
| B | THR505 |
| B | LEU506 |
| B | POL1010 |
| B | HOH1200 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue PGR B 1005 |
| Chain | Residue |
| B | ALA341 |
| B | ARG344 |
| B | TRP377 |
| B | GLU381 |
| B | ALA436 |
| B | HOH1245 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue PGR B 1006 |
| Chain | Residue |
| A | THR420 |
| A | VAL423 |
| A | HOH1302 |
| A | HOH1381 |
| B | PRO231 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue BU1 B 1007 |
| Chain | Residue |
| B | ASN162 |
| B | TYR163 |
| B | LYS164 |
| B | GLY165 |
| B | HOH1169 |
| B | HOH1263 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue BU1 B 1008 |
| Chain | Residue |
| B | GLU520 |
| B | PHE521 |
| B | GLN527 |
| B | LEU530 |
| B | GLN534 |
| B | HOH1196 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue PGR B 1009 |
| Chain | Residue |
| B | LEU69 |
| B | SER71 |
| B | ILE73 |
| B | HOH1249 |
| B | HOH1300 |
| A | THR68 |
| A | LEU69 |
| A | SER71 |
| A | ILE73 |
| B | THR68 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue POL B 1010 |
| Chain | Residue |
| B | HIS262 |
| B | ILE296 |
| B | LEU299 |
| B | ALA300 |
| B | ILE569 |
| B | PGR1004 |
| B | HOH1167 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue PDO B 1011 |
| Chain | Residue |
| A | GLN45 |
| A | SER46 |
| A | HOH1279 |
| A | HOH1410 |
| B | GLN45 |
| B | SER46 |
| B | HOH1117 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue PDO B 1012 |
| Chain | Residue |
| B | ILE330 |
| B | PRO414 |
| B | GLY417 |
| B | ARG418 |
| B | HOH1101 |
| B | HOH1355 |
| B | HOH1435 |
Functional Information from PROSITE/UniProt
| site_id | PS00711 |
| Number of Residues | 15 |
| Details | LIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEaisHlARTHLIlE |
| Chain | Residue | Details |
| A | HIS252-GLU266 |
