5ME6

Crystal Structure of eiF4E from C. melo bound to a CAP analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation
B	0003723	molecular_function	RNA binding
B	0003743	molecular_function	translation initiation factor activity
B	0005737	cellular_component	cytoplasm
B	0006413	biological_process	translational initiation
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005737	cellular_component	cytoplasm
C	0006413	biological_process	translational initiation
D	0003723	molecular_function	RNA binding
D	0003743	molecular_function	translation initiation factor activity
D	0005737	cellular_component	cytoplasm
D	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue M7G A 1000

Chain	Residue
A	PRO126
A	GLU129
A	ARG178
A	TRP187
A	ASP226

---

site_id	AC2
Number of Residues	6
Details	binding site for residue M7G D 1000

Chain	Residue
D	ARG178
D	LYS202
D	TYR118
D	PRO126
D	TRP128
D	GLU129

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Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DLycFKhkIePkWEDpvcanGGKW

Chain	Residue	Details
A	ASP116-TRP139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Region: {"description":"EIF4G-binding","evidences":[{"source":"UniProtKB","id":"P0DXI0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	45
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P0DXI0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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