5ME5

Crystal Structure of eiF4E from C. melo bound to a eIF4G peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005737	cellular_component	cytoplasm
A	0006413	biological_process	translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 301

Chain	Residue
A	HIS106
A	HIS107
A	LYS110
A	HOH405
B	SER1089
B	THR1090

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH403
A	HOH404
A	HIS64
A	SER65
A	HOH401

---

Functional Information from PROSITE/UniProt

site_id	PS00813
Number of Residues	24
Details	IF4E Eukaryotic initiation factor 4E signature. DLycFKhkIePkWEDpvcanGGKW

Chain	Residue	Details
A	ASP116-TRP139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Region: {"description":"EIF4G-binding","evidences":[{"source":"PubMed","id":"28522457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ME5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29557","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28522457","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ME6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---