5M9Q
Human angiogenin PD variant R95Q
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001525 | biological_process | angiogenesis |
A | 0001541 | biological_process | ovarian follicle development |
A | 0001556 | biological_process | oocyte maturation |
A | 0001666 | biological_process | response to hypoxia |
A | 0001890 | biological_process | placenta development |
A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003779 | molecular_function | actin binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004521 | molecular_function | RNA endonuclease activity |
A | 0004540 | molecular_function | RNA nuclease activity |
A | 0005102 | molecular_function | signaling receptor binding |
A | 0005507 | molecular_function | copper ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005604 | cellular_component | basement membrane |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005694 | cellular_component | chromosome |
A | 0005730 | cellular_component | nucleolus |
A | 0005829 | cellular_component | cytosol |
A | 0006651 | biological_process | diacylglycerol biosynthetic process |
A | 0007154 | biological_process | cell communication |
A | 0007202 | biological_process | activation of phospholipase C activity |
A | 0008201 | molecular_function | heparin binding |
A | 0009303 | biological_process | rRNA transcription |
A | 0009725 | biological_process | response to hormone |
A | 0015629 | cellular_component | actin cytoskeleton |
A | 0016078 | biological_process | tRNA decay |
A | 0016477 | biological_process | cell migration |
A | 0017148 | biological_process | negative regulation of translation |
A | 0019731 | biological_process | antibacterial humoral response |
A | 0019843 | molecular_function | rRNA binding |
A | 0030041 | biological_process | actin filament polymerization |
A | 0030154 | biological_process | cell differentiation |
A | 0030426 | cellular_component | growth cone |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0032148 | biological_process | activation of protein kinase B activity |
A | 0032311 | cellular_component | angiogenin-PRI complex |
A | 0032431 | biological_process | activation of phospholipase A2 activity |
A | 0042277 | molecular_function | peptide binding |
A | 0042327 | biological_process | positive regulation of phosphorylation |
A | 0042592 | biological_process | homeostatic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043025 | cellular_component | neuronal cell body |
A | 0045087 | biological_process | innate immune response |
A | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
A | 0050714 | biological_process | positive regulation of protein secretion |
A | 0050830 | biological_process | defense response to Gram-positive bacterium |
A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue SO4 A 201 |
Chain | Residue |
A | MET0 |
A | ARG32 |
A | ARG33 |
A | HOH303 |
A | HOH308 |
A | HOH379 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 202 |
Chain | Residue |
A | HOH318 |
A | HOH327 |
A | ASN49 |
A | LYS50 |
A | ARG51 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue SO4 A 203 |
Chain | Residue |
A | SER37 |
A | HIS114 |
A | LEU115 |
A | ASP116 |
A | GLN117 |
A | SER118 |
A | ARG121 |
A | PEG205 |
A | PEG207 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 204 |
Chain | Residue |
A | ASP2 |
A | ASN3 |
A | SER4 |
A | HOH310 |
A | HOH337 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue PEG A 205 |
Chain | Residue |
A | SER37 |
A | PRO38 |
A | GLU67 |
A | TRP89 |
A | SO4203 |
A | HOH328 |
A | HOH415 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue PEG A 206 |
Chain | Residue |
A | GLN19 |
A | HIS47 |
A | GLY48 |
A | ASN49 |
A | GLN77 |
A | HOH317 |
A | HOH390 |
A | HOH431 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue PEG A 207 |
Chain | Residue |
A | GLN12 |
A | HIS13 |
A | LYS40 |
A | PRO90 |
A | HIS114 |
A | LEU115 |
A | SO4203 |
A | HOH319 |
A | HOH385 |
site_id | AC8 |
Number of Residues | 7 |
Details | binding site for residue PGE A 208 |
Chain | Residue |
A | SER4 |
A | HIS8 |
A | ASN59 |
A | PRO91 |
A | HOH320 |
A | HOH322 |
A | HOH326 |
Functional Information from PROSITE/UniProt
site_id | PS00127 |
Number of Residues | 7 |
Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF |
Chain | Residue | Details |
A | CYS39-PHE45 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
Chain | Residue | Details |
A | HIS13 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:11468363, ECO:0000269|PubMed:9918722 |
Chain | Residue | Details |
A | HIS114 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS40 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2866794 |
Chain | Residue | Details |
A | GLN1 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 564 |
Chain | Residue | Details |
A | HIS13 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
A | LYS40 | electrostatic stabiliser |
A | HIS114 | increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |