Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5M9M

Human angiogenin PD variant Q77P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001541	biological_process	ovarian follicle development
A	0001556	biological_process	oocyte maturation
A	0001666	biological_process	response to hypoxia
A	0001890	biological_process	placenta development
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003779	molecular_function	actin binding
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0004549	molecular_function	tRNA-specific ribonuclease activity
A	0005102	molecular_function	signaling receptor binding
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005604	cellular_component	basement membrane
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007154	biological_process	cell communication
A	0008201	molecular_function	heparin binding
A	0009303	biological_process	rRNA transcription
A	0009725	biological_process	response to hormone
A	0010494	cellular_component	cytoplasmic stress granule
A	0015629	cellular_component	actin cytoskeleton
A	0016078	biological_process	tRNA decay
A	0016477	biological_process	cell migration
A	0017148	biological_process	negative regulation of translation
A	0019731	biological_process	antibacterial humoral response
A	0019843	molecular_function	rRNA binding
A	0023052	biological_process	signaling
A	0030041	biological_process	actin filament polymerization
A	0030139	cellular_component	endocytic vesicle
A	0030154	biological_process	cell differentiation
A	0030426	cellular_component	growth cone
A	0031410	cellular_component	cytoplasmic vesicle
A	0032055	biological_process	negative regulation of translation in response to stress
A	0032311	cellular_component	angiogenin-PRI complex
A	0034063	biological_process	stress granule assembly
A	0042277	molecular_function	peptide binding
A	0042327	biological_process	positive regulation of phosphorylation
A	0042592	biological_process	homeostatic process
A	0042803	molecular_function	protein homodimerization activity
A	0043022	molecular_function	ribosome binding
A	0043025	cellular_component	neuronal cell body
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0050714	biological_process	positive regulation of protein secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0071425	biological_process	hematopoietic stem cell proliferation
B	0001525	biological_process	angiogenesis
B	0001541	biological_process	ovarian follicle development
B	0001556	biological_process	oocyte maturation
B	0001666	biological_process	response to hypoxia
B	0001890	biological_process	placenta development
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003779	molecular_function	actin binding
B	0004519	molecular_function	endonuclease activity
B	0004521	molecular_function	RNA endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0004549	molecular_function	tRNA-specific ribonuclease activity
B	0005102	molecular_function	signaling receptor binding
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005604	cellular_component	basement membrane
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007154	biological_process	cell communication
B	0008201	molecular_function	heparin binding
B	0009303	biological_process	rRNA transcription
B	0009725	biological_process	response to hormone
B	0010494	cellular_component	cytoplasmic stress granule
B	0015629	cellular_component	actin cytoskeleton
B	0016078	biological_process	tRNA decay
B	0016477	biological_process	cell migration
B	0017148	biological_process	negative regulation of translation
B	0019731	biological_process	antibacterial humoral response
B	0019843	molecular_function	rRNA binding
B	0023052	biological_process	signaling
B	0030041	biological_process	actin filament polymerization
B	0030139	cellular_component	endocytic vesicle
B	0030154	biological_process	cell differentiation
B	0030426	cellular_component	growth cone
B	0031410	cellular_component	cytoplasmic vesicle
B	0032055	biological_process	negative regulation of translation in response to stress
B	0032311	cellular_component	angiogenin-PRI complex
B	0034063	biological_process	stress granule assembly
B	0042277	molecular_function	peptide binding
B	0042327	biological_process	positive regulation of phosphorylation
B	0042592	biological_process	homeostatic process
B	0042803	molecular_function	protein homodimerization activity
B	0043022	molecular_function	ribosome binding
B	0043025	cellular_component	neuronal cell body
B	0043066	biological_process	negative regulation of apoptotic process
B	0045087	biological_process	innate immune response
B	0048662	biological_process	negative regulation of smooth muscle cell proliferation
B	0050714	biological_process	positive regulation of protein secretion
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0071425	biological_process	hematopoietic stem cell proliferation
C	0001525	biological_process	angiogenesis
C	0001541	biological_process	ovarian follicle development
C	0001556	biological_process	oocyte maturation
C	0001666	biological_process	response to hypoxia
C	0001890	biological_process	placenta development
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0003779	molecular_function	actin binding
C	0004519	molecular_function	endonuclease activity
C	0004521	molecular_function	RNA endonuclease activity
C	0004540	molecular_function	RNA nuclease activity
C	0004549	molecular_function	tRNA-specific ribonuclease activity
C	0005102	molecular_function	signaling receptor binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005604	cellular_component	basement membrane
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007154	biological_process	cell communication
C	0008201	molecular_function	heparin binding
C	0009303	biological_process	rRNA transcription
C	0009725	biological_process	response to hormone
C	0010494	cellular_component	cytoplasmic stress granule
C	0015629	cellular_component	actin cytoskeleton
C	0016078	biological_process	tRNA decay
C	0016477	biological_process	cell migration
C	0017148	biological_process	negative regulation of translation
C	0019731	biological_process	antibacterial humoral response
C	0019843	molecular_function	rRNA binding
C	0023052	biological_process	signaling
C	0030041	biological_process	actin filament polymerization
C	0030139	cellular_component	endocytic vesicle
C	0030154	biological_process	cell differentiation
C	0030426	cellular_component	growth cone
C	0031410	cellular_component	cytoplasmic vesicle
C	0032055	biological_process	negative regulation of translation in response to stress
C	0032311	cellular_component	angiogenin-PRI complex
C	0034063	biological_process	stress granule assembly
C	0042277	molecular_function	peptide binding
C	0042327	biological_process	positive regulation of phosphorylation
C	0042592	biological_process	homeostatic process
C	0042803	molecular_function	protein homodimerization activity
C	0043022	molecular_function	ribosome binding
C	0043025	cellular_component	neuronal cell body
C	0043066	biological_process	negative regulation of apoptotic process
C	0045087	biological_process	innate immune response
C	0048662	biological_process	negative regulation of smooth muscle cell proliferation
C	0050714	biological_process	positive regulation of protein secretion
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
C	0071425	biological_process	hematopoietic stem cell proliferation
D	0001525	biological_process	angiogenesis
D	0001541	biological_process	ovarian follicle development
D	0001556	biological_process	oocyte maturation
D	0001666	biological_process	response to hypoxia
D	0001890	biological_process	placenta development
D	0001938	biological_process	positive regulation of endothelial cell proliferation
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0003779	molecular_function	actin binding
D	0004519	molecular_function	endonuclease activity
D	0004521	molecular_function	RNA endonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0004549	molecular_function	tRNA-specific ribonuclease activity
D	0005102	molecular_function	signaling receptor binding
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005604	cellular_component	basement membrane
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007154	biological_process	cell communication
D	0008201	molecular_function	heparin binding
D	0009303	biological_process	rRNA transcription
D	0009725	biological_process	response to hormone
D	0010494	cellular_component	cytoplasmic stress granule
D	0015629	cellular_component	actin cytoskeleton
D	0016078	biological_process	tRNA decay
D	0016477	biological_process	cell migration
D	0017148	biological_process	negative regulation of translation
D	0019731	biological_process	antibacterial humoral response
D	0019843	molecular_function	rRNA binding
D	0023052	biological_process	signaling
D	0030041	biological_process	actin filament polymerization
D	0030139	cellular_component	endocytic vesicle
D	0030154	biological_process	cell differentiation
D	0030426	cellular_component	growth cone
D	0031410	cellular_component	cytoplasmic vesicle
D	0032055	biological_process	negative regulation of translation in response to stress
D	0032311	cellular_component	angiogenin-PRI complex
D	0034063	biological_process	stress granule assembly
D	0042277	molecular_function	peptide binding
D	0042327	biological_process	positive regulation of phosphorylation
D	0042592	biological_process	homeostatic process
D	0042803	molecular_function	protein homodimerization activity
D	0043022	molecular_function	ribosome binding
D	0043025	cellular_component	neuronal cell body
D	0043066	biological_process	negative regulation of apoptotic process
D	0045087	biological_process	innate immune response
D	0048662	biological_process	negative regulation of smooth muscle cell proliferation
D	0050714	biological_process	positive regulation of protein secretion
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0071425	biological_process	hematopoietic stem cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 201

Chain	Residue
A	HIS84
A	ARG95
A	HOH302

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG32
A	ARG33
A	HOH328

site_id	AC3
Number of Residues	5
Details	binding site for residue PGE A 203

Chain	Residue
A	ASP41
C	SER4
A	PRO38
A	CYS39
A	LYS40

site_id	AC4
Number of Residues	2
Details	binding site for residue EDO A 204

Chain	Residue
A	ARG101
A	ILE119

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO A 205

Chain	Residue
A	HIS13
A	VAL113
A	HIS114
A	LEU115
A	HOH320
A	HOH335
A	HOH354

site_id	AC6
Number of Residues	5
Details	binding site for residue BTB A 206

Chain	Residue
A	ASN49
A	LYS50
A	ARG51
A	HOH363
D	ARG66

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 B 201

Chain	Residue
B	ARG32
B	ARG33

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 B 202

Chain	Residue
B	SER28
B	ARG31
B	ARG32
B	HOH333

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 C 201

Chain	Residue
C	ARG32
C	ARG33
C	HOH311
C	HOH346

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 C 202

Chain	Residue
B	ARG5
B	HIS8
C	LYS17
C	HOH321
D	TRP89

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 C 203

Chain	Residue
C	ASN49
C	LYS50
C	ARG51

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 C 204

Chain	Residue
A	TRP89
B	LYS17
C	HIS8
C	HOH314
C	HOH322

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO C 205

Chain	Residue
C	SER28
C	ARG31
C	ARG32
C	HOH366
C	HOH382

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO C 206

Chain	Residue
C	HIS114
C	LEU115
C	ASP116
C	GLN117
C	ARG121

site_id	AD6
Number of Residues	7
Details	binding site for residue SO4 D 201

Chain	Residue
A	HIS65
A	ARG66
D	ASN49
D	LYS50
D	ARG51
D	HOH333
D	HOH341

site_id	AD7
Number of Residues	6
Details	binding site for residue SO4 D 202

Chain	Residue
A	ARG70
A	HOH308
D	ARG32
D	ARG33
D	HOH308
D	HOH318

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 D 203

Chain	Residue
A	ARG66
D	ARG51
D	LYS54

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 D 204

Chain	Residue
A	LYS73
D	THR7
D	HIS8
D	THR11
D	HOH326

site_id	AE1
Number of Residues	11
Details	binding site for residue PGE D 205

Chain	Residue
C	GLY20
C	ARG21
C	ALA98
C	HOH309
D	ARG31
D	GLY34
D	HOH304
D	HOH305
D	HOH337
D	HOH354
D	HOH371

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF

Chain	Residue	Details
A	CYS39-PHE45

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:11468363, ECO:0000269\|PubMed:9918722

Chain	Residue	Details
A	HIS13
B	HIS13
C	HIS13
D	HIS13

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000269\|PubMed:11468363, ECO:0000269\|PubMed:9918722

Chain	Residue	Details
A	HIS114
B	HIS114
C	HIS114
D	HIS114

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	LYS40
B	LYS40
C	LYS40
D	LYS40

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:2866794

Chain	Residue	Details
A	GLN1
B	GLN1
C	GLN1
D	GLN1

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
A	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	LYS40	electrostatic stabiliser
A	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
B	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
B	LYS40	electrostatic stabiliser
B	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

site_id	MCSA3
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
C	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
C	LYS40	electrostatic stabiliser
C	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
D	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
D	LYS40	electrostatic stabiliser
D	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)