5M8Q

Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with kojic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. ChCngNfsGHnC

Chain	Residue	Details
A	CYS99-CYS110

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site_id	PS00497
Number of Residues	18
Details	TYROSINASE_1 Tyrosinase CuA-binding region signature. Hegpa.FLtWHRyhLlrlE

Chain	Residue	Details
A	HIS215-GLU232

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site_id	PS00498
Number of Residues	12
Details	TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFVllHtftD

Chain	Residue	Details
A	ASP397-ASP408

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site_id	PS01248
Number of Residues	24
Details	EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. Ch.CngnfsGhnCgtCrpg.Wrgaa...........C

Chain	Residue	Details
A	CYS99-CYS122

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:28661582, ECO:0007744|PDB:5M8L

Chain	Residue	Details
C	HIS192
C	HIS215
C	HIS224
C	HIS377
C	HIS381
C	HIS404
D	HIS192
D	HIS215
D	HIS224
D	HIS377
D	HIS381
D	HIS404
B	HIS192
B	HIS215
B	HIS224
B	HIS377
B	HIS381
B	HIS404
A	HIS192
A	HIS215
A	HIS224
A	HIS377
A	HIS381
A	HIS404

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site_id	SWS_FT_FI2
Number of Residues	24
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:28661582, ECO:0007744|PDB:5M8L

Chain	Residue	Details
C	ASN96
C	ASN104
C	ASN181
C	ASN304
C	ASN350
C	ASN385
D	ASN96
D	ASN104
D	ASN181
D	ASN304
D	ASN350
D	ASN385
B	ASN96
B	ASN104
B	ASN181
B	ASN304
B	ASN350
B	ASN385
A	ASN96
A	ASN104
A	ASN181
A	ASN304
A	ASN350
A	ASN385

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