Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003743 | molecular_function | translation initiation factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006413 | biological_process | translational initiation |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003743 | molecular_function | translation initiation factor activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006413 | biological_process | translational initiation |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003743 | molecular_function | translation initiation factor activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006413 | biological_process | translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue 7L2 A 301 |
| Chain | Residue |
| A | PHE48 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| A | LYS159 |
| A | LYS162 |
| A | ARG186 |
| A | LYS206 |
| A | HOH403 |
| A | HOH414 |
| A | HOH419 |
| A | ASN50 |
| A | HOH429 |
| A | HOH430 |
| A | HOH452 |
| A | HOH485 |
| A | HOH521 |
| A | ASP51 |
| A | LYS52 |
| A | LYS54 |
| A | TRP56 |
| A | GLN57 |
| A | ASN59 |
| A | MET101 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | ILE115 |
| A | THR116 |
| A | GLN121 |
| A | HOH413 |
| A | HOH442 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue 7L2 B 301 |
| Chain | Residue |
| B | PHE48 |
| B | ASN50 |
| B | ASP51 |
| B | LYS52 |
| B | LYS54 |
| B | TRP56 |
| B | ASN59 |
| B | MET101 |
| B | TRP102 |
| B | GLU103 |
| B | ARG157 |
| B | LYS162 |
| B | ARG186 |
| B | HOH418 |
| B | HOH426 |
| B | HOH429 |
| B | HOH447 |
| B | HOH454 |
| B | HOH477 |
| B | HOH478 |
| B | HOH505 |
| B | HOH525 |
| B | HOH527 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | ILE115 |
| B | THR116 |
| B | LEU117 |
| B | GLN121 |
| B | HOH442 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | TRP46 |
| B | GLN57 |
| B | LEU60 |
| B | GLU99 |
| B | MET101 |
| B | HOH512 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue 7L2 C 300 |
| Chain | Residue |
| C | LYS52 |
| C | LYS54 |
| C | TRP56 |
| C | ASN59 |
| C | MET101 |
| C | TRP102 |
| C | GLU103 |
| C | ARG157 |
| C | LYS162 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue 7L2 D 300 |
| Chain | Residue |
| D | ASP51 |
| D | LYS52 |
| D | LYS54 |
| D | TRP56 |
| D | ASN59 |
| D | MET101 |
| D | TRP102 |
| D | ARG157 |
| D | LYS162 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"10394359","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10394359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9200613","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"17689282","evidenceCode":"ECO:0000269"}]} |
