5M6B

structure of recombinant mushroom tyrosinase (abPPO4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0004503	molecular_function	tyrosinase activity
A	0016491	molecular_function	oxidoreductase activity
A	0042438	biological_process	melanin biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0004503	molecular_function	tyrosinase activity
B	0016491	molecular_function	oxidoreductase activity
B	0042438	biological_process	melanin biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0004503	molecular_function	tyrosinase activity
C	0016491	molecular_function	oxidoreductase activity
C	0042438	biological_process	melanin biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0004503	molecular_function	tyrosinase activity
D	0016491	molecular_function	oxidoreductase activity
D	0042438	biological_process	melanin biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CU B 601

Chain	Residue
B	HIS57
B	CYS80
B	HIS82
B	HIS91
B	HIS283
B	CU602

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CU B 602

Chain	Residue
B	HIS283
B	CU601
B	HIS251
B	HIS255
B	PHE279

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CU A 601

Chain	Residue
A	HIS57
A	CYS80
A	HIS82
A	HIS91
A	O603

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CU A 602

Chain	Residue
A	HIS251
A	HIS255
A	PHE279
A	HIS283
A	O603

---

site_id	AC5
Number of Residues	8
Details	binding site for residue O A 603

Chain	Residue
A	HIS57
A	HIS82
A	HIS91
A	HIS251
A	HIS283
A	PHE454
A	CU601
A	CU602

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CU C 601

Chain	Residue
C	HIS57
C	CYS80
C	HIS82
C	HIS91

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CU C 602

Chain	Residue
C	HIS251
C	HIS255
C	PHE279
C	HIS283

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CU D 601

Chain	Residue
D	HIS57
D	CYS80
D	HIS82
D	HIS91

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CU D 602

Chain	Residue
D	HIS251
D	HIS255
D	PHE279
D	HIS283

---

Functional Information from PROSITE/UniProt

site_id	PS00497
Number of Residues	18
Details	TYROSINASE_1 Tyrosinase CuA-binding region signature. Hsqvl.FPtWHRvyVsiyE

Chain	Residue	Details
B	HIS82-GLU99

---

site_id	PS00498
Number of Residues	12
Details	TYROSINASE_2 Tyrosinase and hemocyanins CuB-binding region signature. DPiFWlhHsnvD

Chain	Residue	Details
B	ASP276-ASP287

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9ZP19

Chain	Residue	Details
B	HIS57
A	HIS283
C	HIS57
C	HIS82
C	HIS91
C	HIS251
C	HIS283
D	HIS57
D	HIS82
D	HIS91
D	HIS251
B	HIS82
D	HIS283
B	HIS91
B	HIS251
B	HIS283
A	HIS57
A	HIS82
A	HIS91
A	HIS251

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	HIS255
A	HIS255
C	HIS255
D	HIS255

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Cleavage => ECO:0000305

Chain	Residue	Details
B	GLY379
A	GLY379
C	GLY379
D	GLY379

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: 2'-(S-cysteinyl)-histidine (Cys-His) => ECO:0000250

Chain	Residue	Details
B	CYS80
B	HIS82
A	CYS80
A	HIS82
C	CYS80
C	HIS82
D	CYS80
D	HIS82

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