5M4V

X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0035821	biological_process	modulation of process of another organism
A	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PGO A 101

Chain	Residue
A	LYS10
A	GLY12
A	PRO13
A	PRO13
A	LYS39
A	HOH220
A	HOH235

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 102

Chain	Residue
A	ARG52
A	LYS29
A	CYS30

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site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 103

Chain	Residue
A	GLU49
A	ARG52
A	ARG53

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Functional Information from PROSITE/UniProt

site_id	PS00280
Number of Residues	19
Details	BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FtyGGCkgnanrFstlekC

Chain	Residue	Details
A	PHE33-CYS51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Region: {"description":"Important for binding V2R","evidences":[{"source":"PubMed","id":"28630289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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