5M45
Structure of Acetone Carboxylase purified from Xanthobacter autotrophicus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0018710 | molecular_function | acetone carboxylase activity |
| A | 0140977 | biological_process | cellular detoxification of acetone |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0017168 | molecular_function | 5-oxoprolinase (ATP-hydrolyzing) activity |
| B | 0018710 | molecular_function | acetone carboxylase activity |
| B | 0140977 | biological_process | cellular detoxification of acetone |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0018710 | molecular_function | acetone carboxylase activity |
| C | 0140977 | biological_process | cellular detoxification of acetone |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016874 | molecular_function | ligase activity |
| D | 0018710 | molecular_function | acetone carboxylase activity |
| D | 0140977 | biological_process | cellular detoxification of acetone |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005829 | cellular_component | cytosol |
| E | 0006749 | biological_process | glutathione metabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016874 | molecular_function | ligase activity |
| E | 0017168 | molecular_function | 5-oxoprolinase (ATP-hydrolyzing) activity |
| E | 0018710 | molecular_function | acetone carboxylase activity |
| E | 0140977 | biological_process | cellular detoxification of acetone |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0016874 | molecular_function | ligase activity |
| F | 0018710 | molecular_function | acetone carboxylase activity |
| F | 0140977 | biological_process | cellular detoxification of acetone |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0016874 | molecular_function | ligase activity |
| G | 0018710 | molecular_function | acetone carboxylase activity |
| G | 0140977 | biological_process | cellular detoxification of acetone |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005829 | cellular_component | cytosol |
| H | 0006749 | biological_process | glutathione metabolic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016874 | molecular_function | ligase activity |
| H | 0017168 | molecular_function | 5-oxoprolinase (ATP-hydrolyzing) activity |
| H | 0018710 | molecular_function | acetone carboxylase activity |
| H | 0140977 | biological_process | cellular detoxification of acetone |
| I | 0000166 | molecular_function | nucleotide binding |
| I | 0005524 | molecular_function | ATP binding |
| I | 0016874 | molecular_function | ligase activity |
| I | 0018710 | molecular_function | acetone carboxylase activity |
| I | 0140977 | biological_process | cellular detoxification of acetone |
| J | 0000166 | molecular_function | nucleotide binding |
| J | 0003824 | molecular_function | catalytic activity |
| J | 0005524 | molecular_function | ATP binding |
| J | 0016874 | molecular_function | ligase activity |
| J | 0018710 | molecular_function | acetone carboxylase activity |
| J | 0140977 | biological_process | cellular detoxification of acetone |
| K | 0000166 | molecular_function | nucleotide binding |
| K | 0005524 | molecular_function | ATP binding |
| K | 0005829 | cellular_component | cytosol |
| K | 0006749 | biological_process | glutathione metabolic process |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0016874 | molecular_function | ligase activity |
| K | 0017168 | molecular_function | 5-oxoprolinase (ATP-hydrolyzing) activity |
| K | 0018710 | molecular_function | acetone carboxylase activity |
| K | 0140977 | biological_process | cellular detoxification of acetone |
| L | 0000166 | molecular_function | nucleotide binding |
| L | 0005524 | molecular_function | ATP binding |
| L | 0016874 | molecular_function | ligase activity |
| L | 0018710 | molecular_function | acetone carboxylase activity |
| L | 0140977 | biological_process | cellular detoxification of acetone |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 801 |
| Chain | Residue |
| A | HIS150 |
| A | ASP153 |
| A | HIS175 |
| A | ACT802 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue ACT A 802 |
| Chain | Residue |
| A | TRP479 |
| A | MN801 |
| A | HOH1213 |
| A | HIS150 |
| A | ASP153 |
| A | HIS175 |
| A | MET187 |
| A | TRP401 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 803 |
| Chain | Residue |
| A | GLU53 |
| A | PRO54 |
| A | ILE55 |
| A | LEU56 |
| A | HOH973 |
| A | HOH1002 |
| A | HOH1190 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue AE4 A 804 |
| Chain | Residue |
| A | GLY113 |
| A | GLY116 |
| A | ALA117 |
| A | LYS120 |
| A | TYR376 |
| A | HOH927 |
| A | HOH1211 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 805 |
| Chain | Residue |
| A | SER763 |
| A | VAL768 |
| A | HOH1194 |
| A | HOH1395 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 806 |
| Chain | Residue |
| A | SER759 |
| A | HOH1087 |
| A | HOH1222 |
| A | HOH1356 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | binding site for residue AMP B 801 |
| Chain | Residue |
| B | THR21 |
| B | MET22 |
| B | GLY311 |
| B | GLY312 |
| B | ALA352 |
| B | ASN404 |
| B | PHE405 |
| B | LEU406 |
| B | GLY473 |
| B | ALA474 |
| B | ASP692 |
| B | ALA693 |
| B | THR694 |
| B | THR695 |
| B | MG802 |
| B | HOH901 |
| B | HOH923 |
| B | HOH929 |
| B | HOH1010 |
| B | HOH1066 |
| B | HOH1076 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | MET22 |
| B | ASP24 |
| B | AMP801 |
| B | HOH1011 |
| B | HOH1066 |
| B | HOH1111 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 803 |
| Chain | Residue |
| B | ASP309 |
| B | HOH901 |
| B | HOH923 |
| B | HOH947 |
| B | HOH1150 |
| B | HOH1166 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 804 |
| Chain | Residue |
| B | ACT805 |
| B | HOH1114 |
| B | HOH1161 |
| B | HOH1244 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 805 |
| Chain | Residue |
| A | VAL69 |
| B | ARG123 |
| B | GLY458 |
| B | LYS459 |
| B | MG804 |
| B | HOH1161 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 806 |
| Chain | Residue |
| B | ASP447 |
| B | HOH1061 |
| B | HOH1132 |
| C | ASP19 |
| C | HOH399 |
| C | HOH402 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 201 |
| Chain | Residue |
| C | CYS74 |
| C | CYS76 |
| C | CYS124 |
| C | CYS127 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MN D 801 |
| Chain | Residue |
| D | HIS150 |
| D | ASP153 |
| D | HIS175 |
| D | ACT802 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue ACT D 802 |
| Chain | Residue |
| D | HIS150 |
| D | ASP153 |
| D | HIS175 |
| D | MET187 |
| D | TRP401 |
| D | TRP479 |
| D | MN801 |
| D | HOH1089 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 803 |
| Chain | Residue |
| D | GLU53 |
| D | PRO54 |
| D | ILE55 |
| D | LEU56 |
| D | HOH901 |
| J | GLU163 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue AE4 D 804 |
| Chain | Residue |
| D | GLY113 |
| D | GLY116 |
| D | ALA117 |
| D | LYS120 |
| D | TYR376 |
| D | HOH918 |
| D | HOH1145 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 805 |
| Chain | Residue |
| D | SER763 |
| D | VAL768 |
| D | HOH1116 |
| D | HOH1364 |
| D | HOH1404 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 806 |
| Chain | Residue |
| D | ALA689 |
| D | HOH1133 |
| D | HOH1380 |
| F | HOH428 |
| G | HOH1083 |
| G | HOH1299 |
| site_id | AE2 |
| Number of Residues | 21 |
| Details | binding site for residue AMP E 801 |
| Chain | Residue |
| E | GLY20 |
| E | THR21 |
| E | MET22 |
| E | GLY311 |
| E | GLY312 |
| E | ALA352 |
| E | ASN404 |
| E | PHE405 |
| E | LEU406 |
| E | GLY473 |
| E | ALA474 |
| E | ASP692 |
| E | ALA693 |
| E | THR694 |
| E | THR695 |
| E | MG803 |
| E | HOH922 |
| E | HOH932 |
| E | HOH1012 |
| E | HOH1128 |
| E | HOH1223 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue MG E 802 |
| Chain | Residue |
| E | ASP309 |
| E | HOH907 |
| E | HOH922 |
| E | HOH1210 |
| E | HOH1217 |
| E | HOH1223 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue MG E 803 |
| Chain | Residue |
| E | MET22 |
| E | ASP24 |
| E | AMP801 |
| E | HOH1012 |
| E | HOH1045 |
| E | HOH1114 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue MG E 804 |
| Chain | Residue |
| E | ACT805 |
| E | HOH1136 |
| E | HOH1297 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT E 805 |
| Chain | Residue |
| D | VAL69 |
| E | ARG123 |
| E | GLY458 |
| E | LYS459 |
| E | MG804 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue MG E 806 |
| Chain | Residue |
| E | ASP447 |
| E | HOH1248 |
| F | ASP19 |
| F | HOH337 |
| F | HOH353 |
| F | HOH393 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 201 |
| Chain | Residue |
| F | CYS74 |
| F | CYS76 |
| F | CYS124 |
| F | CYS127 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue MN G 801 |
| Chain | Residue |
| G | HIS150 |
| G | ASP153 |
| G | HIS175 |
| G | ACT802 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue ACT G 802 |
| Chain | Residue |
| G | HIS150 |
| G | ASP153 |
| G | HIS175 |
| G | MET187 |
| G | TRP401 |
| G | TRP479 |
| G | MN801 |
| G | HOH1016 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue ACT G 803 |
| Chain | Residue |
| G | GLU53 |
| G | PRO54 |
| G | ILE55 |
| G | LEU56 |
| G | HOH954 |
| G | HOH962 |
| G | HOH1139 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue AE4 G 804 |
| Chain | Residue |
| G | GLY113 |
| G | GLY116 |
| G | ALA117 |
| G | LYS120 |
| G | TYR376 |
| G | HOH931 |
| G | HOH1240 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue MG G 805 |
| Chain | Residue |
| G | SER763 |
| G | VAL768 |
| G | HOH1149 |
| G | HOH1212 |
| G | HOH1295 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue MG G 806 |
| Chain | Residue |
| D | HOH990 |
| G | ALA689 |
| G | HOH1098 |
| G | HOH1301 |
| site_id | AF6 |
| Number of Residues | 20 |
| Details | binding site for residue AMP H 801 |
| Chain | Residue |
| H | GLY20 |
| H | THR21 |
| H | MET22 |
| H | GLY311 |
| H | GLY312 |
| H | ALA352 |
| H | ASN404 |
| H | PHE405 |
| H | LEU406 |
| H | GLY473 |
| H | ALA474 |
| H | ASP692 |
| H | THR694 |
| H | THR695 |
| H | MG802 |
| H | HOH901 |
| H | HOH947 |
| H | HOH970 |
| H | HOH985 |
| H | HOH1032 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue MG H 802 |
| Chain | Residue |
| H | MET22 |
| H | ASP24 |
| H | AMP801 |
| H | HOH1114 |
| H | HOH1175 |
| H | HOH1183 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue MG H 803 |
| Chain | Residue |
| H | ASP309 |
| H | HOH940 |
| H | HOH970 |
| H | HOH985 |
| H | HOH1120 |
| H | HOH1146 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue MG H 804 |
| Chain | Residue |
| H | ASP447 |
| H | HOH1154 |
| I | ASP19 |
| I | HOH387 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue MG H 805 |
| Chain | Residue |
| H | ACT806 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT H 806 |
| Chain | Residue |
| G | VAL69 |
| H | ARG123 |
| H | GLY458 |
| H | LYS459 |
| H | MG805 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN I 201 |
| Chain | Residue |
| I | CYS74 |
| I | CYS76 |
| I | CYS124 |
| I | CYS127 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue MN J 801 |
| Chain | Residue |
| J | HIS150 |
| J | ASP153 |
| J | HIS175 |
| J | ACT802 |
| site_id | AG5 |
| Number of Residues | 8 |
| Details | binding site for residue ACT J 802 |
| Chain | Residue |
| J | HIS150 |
| J | ASP153 |
| J | HIS175 |
| J | MET187 |
| J | TRP401 |
| J | TRP479 |
| J | MN801 |
| J | HOH1273 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT J 803 |
| Chain | Residue |
| J | GLU53 |
| J | PRO54 |
| J | ILE55 |
| J | LEU56 |
| site_id | AG7 |
| Number of Residues | 7 |
| Details | binding site for residue AE4 J 804 |
| Chain | Residue |
| J | GLY113 |
| J | GLY116 |
| J | ALA117 |
| J | LYS120 |
| J | PHE773 |
| J | HOH957 |
| J | HOH1156 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue MG J 805 |
| Chain | Residue |
| J | SER763 |
| J | VAL768 |
| J | HOH1174 |
| J | HOH1248 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue MG J 806 |
| Chain | Residue |
| J | SER759 |
| J | HOH934 |
| J | HOH999 |
| J | HOH1223 |
| J | HOH1363 |
| site_id | AH1 |
| Number of Residues | 21 |
| Details | binding site for residue AMP K 801 |
| Chain | Residue |
| K | GLY20 |
| K | THR21 |
| K | MET22 |
| K | GLY311 |
| K | GLY312 |
| K | ALA352 |
| K | ASN404 |
| K | PHE405 |
| K | LEU406 |
| K | GLY473 |
| K | ALA474 |
| K | ASP692 |
| K | ALA693 |
| K | THR694 |
| K | THR695 |
| K | MG802 |
| K | HOH956 |
| K | HOH976 |
| K | HOH1006 |
| K | HOH1037 |
| K | HOH1095 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue MG K 802 |
| Chain | Residue |
| K | MET22 |
| K | ASP24 |
| K | AMP801 |
| K | HOH960 |
| K | HOH1095 |
| K | HOH1129 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue MG K 803 |
| Chain | Residue |
| K | ASP309 |
| K | HOH976 |
| K | HOH979 |
| K | HOH1006 |
| K | HOH1195 |
| K | HOH1205 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue MG K 804 |
| Chain | Residue |
| K | ACT805 |
| K | HOH1050 |
| K | HOH1248 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT K 805 |
| Chain | Residue |
| J | VAL69 |
| J | GLU73 |
| K | ARG123 |
| K | GLY458 |
| K | LYS459 |
| K | MG804 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN L 201 |
| Chain | Residue |
| L | CYS74 |
| L | CYS76 |
| L | CYS124 |
| L | CYS127 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue MG L 202 |
| Chain | Residue |
| K | ASP447 |
| K | HOH1191 |
| K | HOH1252 |
| L | ASP19 |
| L | HOH400 |
| L | HOH401 |
