5M44

Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under high-salt conditions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 7EY A 401

Chain	Residue
A	LEU45
A	VAL53
A	GLU55
A	ILE95
A	GLU114
A	HIS115
A	MET163
A	CL403

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site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 402

Chain	Residue
A	TYR188
A	ASN189
A	ARG155

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site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 403

Chain	Residue
A	LYS68
A	ILE95
A	ASP175
A	7EY401

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 404

Chain	Residue
A	PRO159
A	HIS160

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site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 405

Chain	Residue
A	HIS148
A	ALA315

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site_id	AC6
Number of Residues	3
Details	binding site for residue CL A 406

Chain	Residue
A	LYS229
A	PHE232
A	HIS234

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
A	LEU45-LYS68

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	ASP156

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU45
A	LYS68

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