5M2X
Crystal structure of the full-length Zika virus NS5 protein (Human isolate Z1106033)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0004483 | molecular_function | methyltransferase cap1 activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0004483 | molecular_function | methyltransferase cap1 activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| C | 0039694 | biological_process | viral RNA genome replication |
| D | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| D | 0004483 | molecular_function | methyltransferase cap1 activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0032259 | biological_process | methylation |
| D | 0039694 | biological_process | viral RNA genome replication |
| E | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| E | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| E | 0004483 | molecular_function | methyltransferase cap1 activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0008168 | molecular_function | methyltransferase activity |
| E | 0032259 | biological_process | methylation |
| E | 0039694 | biological_process | viral RNA genome replication |
| F | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| F | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| F | 0004483 | molecular_function | methyltransferase cap1 activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0008168 | molecular_function | methyltransferase activity |
| F | 0032259 | biological_process | methylation |
| F | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SAH A 1001 |
| Chain | Residue |
| A | SER56 |
| A | VAL132 |
| A | ASP146 |
| A | GLY81 |
| A | CYS82 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| A | HIS110 |
| A | VAL130 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 1002 |
| Chain | Residue |
| A | SER712 |
| A | ARG731 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 1003 |
| Chain | Residue |
| A | ARG57 |
| A | ARG213 |
| B | LYS45 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1004 |
| Chain | Residue |
| A | HIS714 |
| A | ASN716 |
| A | CYS730 |
| A | CYS849 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1005 |
| Chain | Residue |
| A | GLU439 |
| A | HIS443 |
| A | CYS448 |
| A | CYS451 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue SAH B 1001 |
| Chain | Residue |
| B | SER56 |
| B | GLY58 |
| B | GLY81 |
| B | CYS82 |
| B | TRP87 |
| B | THR104 |
| B | LYS105 |
| B | HIS110 |
| B | GLU111 |
| B | VAL130 |
| B | ASP131 |
| B | PHE133 |
| B | ASP146 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 B 1002 |
| Chain | Residue |
| A | LYS45 |
| B | ARG57 |
| B | ARG213 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 1003 |
| Chain | Residue |
| B | HIS855 |
| B | ARG856 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1004 |
| Chain | Residue |
| B | HIS714 |
| B | ASN716 |
| B | CYS730 |
| B | CYS849 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue SAH C 1001 |
| Chain | Residue |
| C | SER56 |
| C | GLY58 |
| C | GLY81 |
| C | CYS82 |
| C | TRP87 |
| C | THR104 |
| C | LYS105 |
| C | HIS110 |
| C | ASP146 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 C 1002 |
| Chain | Residue |
| C | LYS76 |
| C | GLU99 |
| C | LYS101 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1003 |
| Chain | Residue |
| C | HIS714 |
| C | ASN716 |
| C | CYS730 |
| C | CYS849 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1004 |
| Chain | Residue |
| C | GLU439 |
| C | HIS443 |
| C | CYS448 |
| C | CYS451 |
| site_id | AD5 |
| Number of Residues | 12 |
| Details | binding site for residue SAH D 1001 |
| Chain | Residue |
| D | SER56 |
| D | GLY58 |
| D | GLY81 |
| D | CYS82 |
| D | GLY86 |
| D | TRP87 |
| D | THR104 |
| D | LYS105 |
| D | HIS110 |
| D | GLU111 |
| D | VAL130 |
| D | ASP146 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 D 1002 |
| Chain | Residue |
| D | LYS101 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 D 1003 |
| Chain | Residue |
| D | ARG125 |
| D | ASP692 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 D 1004 |
| Chain | Residue |
| D | LYS359 |
| D | LYS470 |
| D | ARG473 |
| D | LYS691 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 D 1005 |
| Chain | Residue |
| D | SER712 |
| D | ARG731 |
| D | ARG739 |
| D | SER798 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 1006 |
| Chain | Residue |
| D | HIS714 |
| D | ASN716 |
| D | CYS730 |
| D | CYS849 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 1007 |
| Chain | Residue |
| D | GLU439 |
| D | HIS443 |
| D | CYS448 |
| D | SER450 |
| D | CYS451 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for residue SAH E 1001 |
| Chain | Residue |
| E | GLY81 |
| E | CYS82 |
| E | GLY85 |
| E | GLY86 |
| E | TRP87 |
| E | THR104 |
| E | LYS105 |
| E | HIS110 |
| E | GLU111 |
| E | ASP146 |
| E | SER56 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 E 1002 |
| Chain | Residue |
| E | ARG57 |
| E | ARG213 |
| F | LYS45 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 E 1003 |
| Chain | Residue |
| E | HIS855 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1004 |
| Chain | Residue |
| E | HIS714 |
| E | ASN716 |
| E | CYS730 |
| E | CYS849 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 1005 |
| Chain | Residue |
| E | GLU439 |
| E | HIS443 |
| E | CYS448 |
| E | CYS451 |
| site_id | AE8 |
| Number of Residues | 14 |
| Details | binding site for residue SAH F 1001 |
| Chain | Residue |
| F | SER56 |
| F | GLY58 |
| F | GLY81 |
| F | CYS82 |
| F | GLY85 |
| F | GLY86 |
| F | TRP87 |
| F | THR104 |
| F | LYS105 |
| F | HIS110 |
| F | GLU111 |
| F | VAL130 |
| F | ASP146 |
| F | ILE147 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 F 1002 |
| Chain | Residue |
| F | SER712 |
| F | ARG739 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 F 1003 |
| Chain | Residue |
| F | ARG473 |
| F | LYS691 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 F 1004 |
| Chain | Residue |
| F | LYS76 |
| F | GLU99 |
| F | LYS101 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1006 |
| Chain | Residue |
| F | HIS714 |
| F | ASN716 |
| F | CYS730 |
| F | CYS849 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 1007 |
| Chain | Residue |
| F | GLU439 |
| F | HIS443 |
| F | CYS448 |
| F | CYS451 |
