5M2E

Apo structure of Pseudomonas aeruginosa Isocitrate Dehydrogenase, ICD.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
A	0005576	cellular_component	extracellular region
A	0006097	biological_process	glyoxylate cycle
A	0006099	biological_process	tricarboxylic acid cycle
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
B	0005576	cellular_component	extracellular region
B	0006097	biological_process	glyoxylate cycle
B	0006099	biological_process	tricarboxylic acid cycle
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
C	0005576	cellular_component	extracellular region
C	0006097	biological_process	glyoxylate cycle
C	0006099	biological_process	tricarboxylic acid cycle
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0004450	molecular_function	isocitrate dehydrogenase (NADP+) activity
D	0005576	cellular_component	extracellular region
D	0006097	biological_process	glyoxylate cycle
D	0006099	biological_process	tricarboxylic acid cycle
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLNGDYlSDalAaev.GGIGI

Chain	Residue	Details
A	ASN305-ILE324

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P08200

Chain	Residue	Details
A	ARG121
B	ASP285
B	ASP309
B	ASP313
C	ARG121
C	ARG131
C	ARG155
C	ASP285
C	ASP309
C	ASP313
D	ARG121
A	ARG131
D	ARG131
D	ARG155
D	ASP285
D	ASP309
D	ASP313
A	ARG155
A	ASP285
A	ASP309
A	ASP313
B	ARG121
B	ARG131
B	ARG155

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Critical for catalysis => ECO:0000250|UniProtKB:P08200

Chain	Residue	Details
A	TYR162
A	LYS232
B	TYR162
B	LYS232
C	TYR162
C	LYS232
D	TYR162
D	LYS232

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:24965220, ECO:0000269|PubMed:25096199

Chain	Residue	Details
A	SER115
B	SER115
C	SER115
D	SER115

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:24965220

Chain	Residue	Details
A	THR193
B	THR193
C	THR193
D	THR193

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