Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LZL

Pyrobaculum calidifontis 5-aminolaevulinic acid dehydratase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004655	molecular_function	porphobilinogen synthase activity
A	0005829	cellular_component	cytosol
A	0006779	biological_process	porphyrin-containing compound biosynthetic process
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004655	molecular_function	porphobilinogen synthase activity
B	0005829	cellular_component	cytosol
B	0006779	biological_process	porphyrin-containing compound biosynthetic process
B	0006782	biological_process	protoporphyrinogen IX biosynthetic process
B	0006783	biological_process	heme biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0033014	biological_process	tetrapyrrole biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004655	molecular_function	porphobilinogen synthase activity
C	0005829	cellular_component	cytosol
C	0006779	biological_process	porphyrin-containing compound biosynthetic process
C	0006782	biological_process	protoporphyrinogen IX biosynthetic process
C	0006783	biological_process	heme biosynthetic process
C	0008270	molecular_function	zinc ion binding
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0033014	biological_process	tetrapyrrole biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004655	molecular_function	porphobilinogen synthase activity
D	0005829	cellular_component	cytosol
D	0006779	biological_process	porphyrin-containing compound biosynthetic process
D	0006782	biological_process	protoporphyrinogen IX biosynthetic process
D	0006783	biological_process	heme biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0033014	biological_process	tetrapyrrole biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0004655	molecular_function	porphobilinogen synthase activity
E	0005829	cellular_component	cytosol
E	0006779	biological_process	porphyrin-containing compound biosynthetic process
E	0006782	biological_process	protoporphyrinogen IX biosynthetic process
E	0006783	biological_process	heme biosynthetic process
E	0008270	molecular_function	zinc ion binding
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0033014	biological_process	tetrapyrrole biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0004655	molecular_function	porphobilinogen synthase activity
F	0005829	cellular_component	cytosol
F	0006779	biological_process	porphyrin-containing compound biosynthetic process
F	0006782	biological_process	protoporphyrinogen IX biosynthetic process
F	0006783	biological_process	heme biosynthetic process
F	0008270	molecular_function	zinc ion binding
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0033014	biological_process	tetrapyrrole biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0004655	molecular_function	porphobilinogen synthase activity
G	0005829	cellular_component	cytosol
G	0006779	biological_process	porphyrin-containing compound biosynthetic process
G	0006782	biological_process	protoporphyrinogen IX biosynthetic process
G	0006783	biological_process	heme biosynthetic process
G	0008270	molecular_function	zinc ion binding
G	0016829	molecular_function	lyase activity
G	0016836	molecular_function	hydro-lyase activity
G	0033014	biological_process	tetrapyrrole biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0004655	molecular_function	porphobilinogen synthase activity
H	0005829	cellular_component	cytosol
H	0006779	biological_process	porphyrin-containing compound biosynthetic process
H	0006782	biological_process	protoporphyrinogen IX biosynthetic process
H	0006783	biological_process	heme biosynthetic process
H	0008270	molecular_function	zinc ion binding
H	0016829	molecular_function	lyase activity
H	0016836	molecular_function	hydro-lyase activity
H	0033014	biological_process	tetrapyrrole biosynthetic process
H	0046872	molecular_function	metal ion binding
I	0004655	molecular_function	porphobilinogen synthase activity
I	0005829	cellular_component	cytosol
I	0006779	biological_process	porphyrin-containing compound biosynthetic process
I	0006782	biological_process	protoporphyrinogen IX biosynthetic process
I	0006783	biological_process	heme biosynthetic process
I	0008270	molecular_function	zinc ion binding
I	0016829	molecular_function	lyase activity
I	0016836	molecular_function	hydro-lyase activity
I	0033014	biological_process	tetrapyrrole biosynthetic process
I	0046872	molecular_function	metal ion binding
J	0004655	molecular_function	porphobilinogen synthase activity
J	0005829	cellular_component	cytosol
J	0006779	biological_process	porphyrin-containing compound biosynthetic process
J	0006782	biological_process	protoporphyrinogen IX biosynthetic process
J	0006783	biological_process	heme biosynthetic process
J	0008270	molecular_function	zinc ion binding
J	0016829	molecular_function	lyase activity
J	0016836	molecular_function	hydro-lyase activity
J	0033014	biological_process	tetrapyrrole biosynthetic process
J	0046872	molecular_function	metal ion binding
K	0004655	molecular_function	porphobilinogen synthase activity
K	0005829	cellular_component	cytosol
K	0006779	biological_process	porphyrin-containing compound biosynthetic process
K	0006782	biological_process	protoporphyrinogen IX biosynthetic process
K	0006783	biological_process	heme biosynthetic process
K	0008270	molecular_function	zinc ion binding
K	0016829	molecular_function	lyase activity
K	0016836	molecular_function	hydro-lyase activity
K	0033014	biological_process	tetrapyrrole biosynthetic process
K	0046872	molecular_function	metal ion binding
L	0004655	molecular_function	porphobilinogen synthase activity
L	0005829	cellular_component	cytosol
L	0006779	biological_process	porphyrin-containing compound biosynthetic process
L	0006782	biological_process	protoporphyrinogen IX biosynthetic process
L	0006783	biological_process	heme biosynthetic process
L	0008270	molecular_function	zinc ion binding
L	0016829	molecular_function	lyase activity
L	0016836	molecular_function	hydro-lyase activity
L	0033014	biological_process	tetrapyrrole biosynthetic process
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS125
A	CYS127
A	CYS135

site_id	AC2
Number of Residues	2
Details	binding site for residue ZN A 402

Chain	Residue
A	GLU242
A	ASP246

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS125
B	CYS127
B	CYS135

site_id	AC4
Number of Residues	2
Details	binding site for residue ZN B 402

Chain	Residue
B	ASP246
B	GLU242

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN C 401

Chain	Residue
C	CYS125
C	CYS127
C	CYS135
C	SER174

site_id	AC6
Number of Residues	2
Details	binding site for residue ZN C 402

Chain	Residue
C	GLU242
C	ASP246

site_id	AC7
Number of Residues	3
Details	binding site for residue ZN D 401

Chain	Residue
D	CYS125
D	CYS127
D	CYS135

site_id	AC8
Number of Residues	2
Details	binding site for residue ZN D 402

Chain	Residue
D	GLU242
D	ASP246

site_id	AC9
Number of Residues	3
Details	binding site for residue ZN E 401

Chain	Residue
E	CYS125
E	CYS127
E	CYS135

site_id	AD1
Number of Residues	2
Details	binding site for residue ZN E 402

Chain	Residue
E	GLU242
E	ASP246

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN F 401

Chain	Residue
F	CYS125
F	CYS127
F	CYS135

site_id	AD3
Number of Residues	2
Details	binding site for residue ZN F 402

Chain	Residue
F	GLU242
F	ASP246

site_id	AD4
Number of Residues	3
Details	binding site for residue ZN G 401

Chain	Residue
G	CYS125
G	CYS127
G	CYS135

site_id	AD5
Number of Residues	2
Details	binding site for residue ZN G 402

Chain	Residue
G	GLU242
G	ASP246

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN H 401

Chain	Residue
H	CYS125
H	CYS127
H	CYS135
H	SER174

site_id	AD7
Number of Residues	3
Details	binding site for residue ZN H 402

Chain	Residue
H	MET176
H	GLU242
H	ASP246

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN I 401

Chain	Residue
I	CYS125
I	CYS127
I	CYS135
I	SER174

site_id	AD9
Number of Residues	1
Details	binding site for residue ZN I 402

Chain	Residue
I	GLU242

site_id	AE1
Number of Residues	3
Details	binding site for residue ZN J 401

Chain	Residue
J	CYS125
J	CYS127
J	CYS135

site_id	AE2
Number of Residues	2
Details	binding site for residue ZN J 402

Chain	Residue
J	GLU242
J	ASP246

site_id	AE3
Number of Residues	5
Details	binding site for residue ZN K 401

Chain	Residue
K	CYS125
K	CYS127
K	CYS135
K	SER174
K	ARG226

site_id	AE4
Number of Residues	2
Details	binding site for residue ZN K 402

Chain	Residue
K	GLU242
K	ASP246

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN L 401

Chain	Residue
L	CYS125
L	CYS127
L	CYS135
L	SER174

site_id	AE6
Number of Residues	2
Details	binding site for residue ZN L 402

Chain	Residue
L	GLU242
L	ASP246

site_id	AE7
Number of Residues	15
Details	binding site for Di-peptide CYS K 135 and ARG K 226

Chain	Residue
K	CYS125
K	CYS127
K	GLY133
K	HIS134
K	GLY136
K	THR152
K	TYR156
K	ARG214
K	SER219
K	ASP225
K	ARG227
K	THR228
K	TYR229
K	GLN230
K	ZN401

Functional Information from PROSITE/UniProt

site_id	PS00169
Number of Residues	13
Details	D_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDiVMVKPAlaY

Chain	Residue	Details
A	GLY250-TYR262

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)