Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue 7AA A 501 |
| Chain | Residue |
| A | ILE155 |
| A | LEU231 |
| A | SER232 |
| A | ASN234 |
| A | GLU279 |
| A | LEU282 |
| A | ILE294 |
| A | EDO504 |
| A | GLY156 |
| A | LYS157 |
| A | VAL163 |
| A | ALA176 |
| A | LYS178 |
| A | ILE212 |
| A | PHE228 |
| A | GLU229 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | LYS165 |
| A | HOH654 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | GLU363 |
| A | LYS413 |
| A | ARG415 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ILE155 |
| A | SER232 |
| A | MET233 |
| A | ASN234 |
| A | 7AA501 |
| A | HOH699 |
| A | HOH710 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | HIS199 |
| A | LYS202 |
| B | ASP437 |
| B | GLN441 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 507 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | PRO350 |
| A | LYS413 |
| A | ARG415 |
| B | ARG411 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | SER104 |
| A | TYR105 |
| A | HOH633 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue 7AA B 501 |
| Chain | Residue |
| B | ILE155 |
| B | GLY156 |
| B | LYS157 |
| B | PHE160 |
| B | VAL163 |
| B | ALA176 |
| B | LYS178 |
| B | ILE212 |
| B | PHE228 |
| B | GLU229 |
| B | LEU231 |
| B | GLU279 |
| B | LEU282 |
| B | ILE294 |
| B | ASP295 |
| B | HOH673 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| A | LYS202 |
| B | LEU436 |
| B | LYS440 |
| B | HOH646 |
| B | HOH719 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | LYS277 |
| B | GLU279 |
| B | SER312 |
| B | HOH605 |
| B | HOH643 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | LYS386 |
| B | TYR388 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydhkvhqh..........VALK |
| Chain | Residue | Details |
| A | ILE155-LYS178 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL |
| Chain | Residue | Details |
| A | ILE271-LEU283 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"19965871","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAP3K10","evidences":[{"source":"PubMed","id":"18455992","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"22998443","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by ATM","evidences":[{"source":"PubMed","id":"19965871","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by MAP3K10","evidences":[{"source":"PubMed","id":"18455992","evidenceCode":"ECO:0000269"}]} |
