5LWV

Human OGT in complex with UDP and fused substrate peptide (HCF1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue UDP A 1201

Chain	Residue
A	PRO559
A	ARG904
A	HIS920
A	THR921
A	THR922
A	ASP925
A	HOH1322
A	HOH1399
A	HOH1469
A	HOH1505
A	HOH1630
A	ASN838
A	GLN839
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 1202

Chain	Residue
A	GLY365
A	LYS366
A	LEU367
A	GLN368
A	GLU369
A	HOH1306
A	HOH1449

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site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 A 1203

Chain	Residue
A	ARG328
A	ARG491
A	LEU492
A	HOH1431
A	HOH1689

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site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 1204

Chain	Residue
A	ASN962
A	ARG963
A	HOH1309

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:7590226

Chain	Residue	Details
A	GLU297

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539

Chain	Residue	Details
A	GLY508

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW

Chain	Residue	Details
A	ALA852
A	GLN906
A	CYS911
A	GLY930
A	THR935
A	GLN849

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	ASP454

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558

Chain	Residue	Details
A	LYS989

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	GLN399

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