5LVS
Self-assembled protein-aromatic foldamer complexes with 2:3 and 2:2:1 stoichiometries
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002009 | biological_process | morphogenesis of an epithelium |
| A | 0004064 | molecular_function | arylesterase activity |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015670 | biological_process | carbon dioxide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0018820 | molecular_function | cyanamide hydratase activity |
| A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| A | 0032849 | biological_process | positive regulation of cellular pH reduction |
| A | 0038166 | biological_process | angiotensin-activated signaling pathway |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0044070 | biological_process | regulation of monoatomic anion transport |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046903 | biological_process | secretion |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0070050 | biological_process | neuron cellular homeostasis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 2001150 | biological_process | positive regulation of dipeptide transmembrane transport |
| A | 2001225 | biological_process | regulation of chloride transport |
| B | 0002009 | biological_process | morphogenesis of an epithelium |
| B | 0004064 | molecular_function | arylesterase activity |
| B | 0004089 | molecular_function | carbonate dehydratase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015670 | biological_process | carbon dioxide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0018820 | molecular_function | cyanamide hydratase activity |
| B | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| B | 0032849 | biological_process | positive regulation of cellular pH reduction |
| B | 0038166 | biological_process | angiotensin-activated signaling pathway |
| B | 0043209 | cellular_component | myelin sheath |
| B | 0044070 | biological_process | regulation of monoatomic anion transport |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046903 | biological_process | secretion |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0070050 | biological_process | neuron cellular homeostasis |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 2001150 | biological_process | positive regulation of dipeptide transmembrane transport |
| B | 2001225 | biological_process | regulation of chloride transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | 6H0302 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | QUK313 |
| A | QUJ314 |
| A | HOH435 |
| A | HOH564 |
| A | TRP5 |
| A | PHE20 |
| A | PRO200 |
| A | PRO201 |
| A | QUK303 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | ASN62 |
| A | HIS64 |
| A | ALA65 |
| A | ASN67 |
| A | GLN92 |
| A | HIS94 |
| A | THR199 |
| A | HOH459 |
| A | HOH498 |
| A | HOH513 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | TYR7 |
| A | PRO13 |
| A | ASP242 |
| A | TRP244 |
| A | HOH411 |
| A | HOH412 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | ASN67 |
| A | GLN92 |
| A | PHE130 |
| A | 6H0302 |
| A | QUJ311 |
| A | HOH407 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 310 |
| Chain | Residue |
| A | THR35 |
| A | ALA38 |
| A | TRP191 |
| A | PHE259 |
| A | LYS260 |
| A | HOH570 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 302 |
| Chain | Residue |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | 6H0303 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue 6H0 B 303 |
| Chain | Residue |
| A | QUJ311 |
| A | HOH402 |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | PHE130 |
| B | LEU197 |
| B | THR198 |
| B | THR199 |
| B | PRO201 |
| B | TRP208 |
| B | ZN302 |
| B | QUK304 |
| B | QVS305 |
| B | GOL307 |
| B | GOL308 |
| B | GOL311 |
| B | QUJ314 |
| B | QUK315 |
| B | HOH426 |
| B | HOH478 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 307 |
| Chain | Residue |
| B | TRP5 |
| B | PRO200 |
| B | PRO201 |
| B | 6H0303 |
| B | QUK315 |
| B | HOH442 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 308 |
| Chain | Residue |
| B | ASN62 |
| B | ALA65 |
| B | ASN67 |
| B | GLN92 |
| B | HIS94 |
| B | THR199 |
| B | 6H0303 |
| B | HOH472 |
| B | HOH490 |
| B | HOH539 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 309 |
| Chain | Residue |
| B | TYR7 |
| B | PRO13 |
| B | ASP242 |
| B | TRP244 |
| B | HOH402 |
| B | HOH407 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 310 |
| Chain | Residue |
| A | ASN177 |
| B | LYS167 |
| B | ASN229 |
| B | ASN231 |
| B | GLY232 |
| B | GLU233 |
| B | GLY234 |
| B | GLU235 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 311 |
| Chain | Residue |
| B | 6H0303 |
| B | HOH403 |
| B | ASN67 |
| B | GLN92 |
| B | PHE130 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 312 |
| Chain | Residue |
| B | TYR51 |
| B | ASP52 |
| B | ALA54 |
| B | LYS126 |
| B | ASN177 |
| B | ASP179 |
| B | ARG181 |
| B | HOH513 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 313 |
| Chain | Residue |
| B | THR35 |
| B | ALA38 |
| B | TRP191 |
| B | PHE259 |
| B | LYS260 |
| B | HOH509 |
| site_id | AD7 |
| Number of Residues | 25 |
| Details | binding site for residues 6H0 A 302 and QUJ B 301 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | PHE130 |
| A | LEU197 |
| A | THR198 |
| A | THR199 |
| A | PRO201 |
| A | TRP208 |
| A | QUK303 |
| A | QVS304 |
| A | QVE305 |
| A | GOL309 |
| A | QUK313 |
| A | QUJ314 |
| A | HOH422 |
| A | HOH484 |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | PHE130 |
| B | GLY131 |
| B | 6H0303 |
| B | QUJ314 |
| B | HOH401 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residues QUK A 303 and QVS A 304 |
| Chain | Residue |
| A | HIS3 |
| A | ASP19 |
| A | PHE20 |
| A | 6H0302 |
| A | QVE305 |
| A | GOL306 |
| A | QUK313 |
| A | HOH519 |
| A | HOH586 |
| B | ASP129 |
| B | LYS132 |
| B | QUJ301 |
| B | QUJ314 |
| site_id | AD9 |
| Number of Residues | 32 |
| Details | binding site for residues QUK A 303 and QUJ B 301 |
| Chain | Residue |
| A | HIS3 |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | 6H0302 |
| A | QVS304 |
| A | QVE305 |
| A | GOL306 |
| A | QUJ311 |
| A | QUK313 |
| A | HOH402 |
| A | HOH519 |
| B | HIS94 |
| B | HIS96 |
| B | HIS119 |
| B | PHE130 |
| B | GLY131 |
| B | LEU197 |
| B | THR198 |
| B | THR199 |
| B | PRO201 |
| B | TRP208 |
| B | ZN302 |
| B | QUK304 |
| B | QVS305 |
| B | GOL307 |
| B | GOL308 |
| B | GOL311 |
| B | QUJ314 |
| B | QUK315 |
| B | HOH426 |
| B | HOH478 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for residues QVS A 304 and QVE A 305 |
| Chain | Residue |
| A | SER2 |
| A | HIS3 |
| A | ASP19 |
| A | PHE20 |
| A | 6H0302 |
| A | QUK303 |
| A | HOH465 |
| A | HOH477 |
| A | HOH586 |
| B | ASP129 |
| B | LYS132 |
| B | QUJ301 |
| site_id | AE2 |
| Number of Residues | 23 |
| Details | binding site for residues QUJ A 311 and QUK B 304 |
| Chain | Residue |
| A | HIS3 |
| A | ASP19 |
| A | PHE20 |
| A | GLY131 |
| A | 6H0302 |
| A | QUK303 |
| A | QVE305 |
| A | GOL309 |
| A | QUJ314 |
| A | HOH586 |
| B | HIS3 |
| B | ASN67 |
| B | GLN92 |
| B | ASP129 |
| B | PHE130 |
| B | LYS132 |
| B | QUJ301 |
| B | 6H0303 |
| B | QVS305 |
| B | QVE306 |
| B | QUK315 |
| B | HOH403 |
| B | HOH525 |
| site_id | AE3 |
| Number of Residues | 15 |
| Details | binding site for residues FOR A 312 and QUK B 315 |
| Chain | Residue |
| A | QUJ311 |
| A | QUK313 |
| A | QUJ314 |
| B | TYR51 |
| B | ASP52 |
| B | ALA54 |
| B | LYS126 |
| B | ASN177 |
| B | ASP179 |
| B | ARG181 |
| B | 6H0303 |
| B | QUK304 |
| B | GOL307 |
| B | QUJ314 |
| B | HOH513 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residues FOR A 312 and QUK A 313 |
| Chain | Residue |
| A | 6H0302 |
| A | QUK303 |
| A | GOL306 |
| A | QUJ314 |
| B | QUJ301 |
| B | QUJ314 |
| B | QUK315 |
| site_id | AE5 |
| Number of Residues | 21 |
| Details | binding site for residues QUK A 313 and QUJ B 314 |
| Chain | Residue |
| A | 6H0302 |
| A | QUK303 |
| A | GOL306 |
| A | QUJ311 |
| A | FOR312 |
| A | HOH435 |
| A | HOH479 |
| A | HOH578 |
| B | THR35 |
| B | ALA38 |
| B | TRP191 |
| B | PHE259 |
| B | LYS260 |
| B | QUJ301 |
| B | 6H0303 |
| B | QUK304 |
| B | QUK315 |
| B | HOH428 |
| B | HOH509 |
| B | HOH524 |
| B | HOH597 |
| site_id | AE6 |
| Number of Residues | 16 |
| Details | binding site for residues QUJ A 314 and QUK B 315 |
| Chain | Residue |
| A | 6H0302 |
| A | QUK303 |
| A | GOL306 |
| A | QUJ311 |
| A | FOR312 |
| A | QUK313 |
| A | HOH435 |
| A | HOH479 |
| A | HOH578 |
| B | QUJ301 |
| B | 6H0303 |
| B | QUK304 |
| B | GOL307 |
| B | HOH428 |
| B | HOH524 |
| B | HOH597 |
| site_id | AE7 |
| Number of Residues | 11 |
| Details | binding site for residues QUK B 304 and QVS B 305 |
| Chain | Residue |
| A | ASP129 |
| A | LYS132 |
| A | QUJ311 |
| A | QUJ314 |
| A | HOH565 |
| B | HIS3 |
| B | ASP19 |
| B | 6H0303 |
| B | QVE306 |
| B | QUK315 |
| B | HOH525 |
| site_id | AE8 |
| Number of Residues | 10 |
| Details | binding site for residues QVS B 305 and QVE B 306 |
| Chain | Residue |
| A | ASP129 |
| A | LYS132 |
| A | QUJ311 |
| A | HOH565 |
| B | HIS3 |
| B | ASP19 |
| B | 6H0303 |
| B | QUK304 |
| B | HOH421 |
| B | HOH564 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdkkkYaaELHLV |
| Chain | Residue | Details |
| A | SER105-VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962 |
| Chain | Residue | Details |
| A | HIS64 | |
| B | HIS64 |
| Chain | Residue | Details |
| A | HIS94 | |
| B | HIS94 |
| Chain | Residue | Details |
| A | HIS96 | |
| A | HIS119 | |
| B | HIS96 | |
| B | HIS119 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:19520834 |
| Chain | Residue | Details |
| A | THR198 | |
| B | THR198 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Fine-tunes the proton-transfer properties of H-64 => ECO:0000305|PubMed:17330962 |
| Chain | Residue | Details |
| A | TYR7 | |
| B | TYR7 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Fine-tunes the proton-transfer properties of H-64; involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
| Chain | Residue | Details |
| A | ASN62 | |
| A | ASN67 | |
| B | ASN62 | |
| B | ASN67 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Involved in the binding of some activators, including histamine and L-histidine => ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:9265618, ECO:0000305|PubMed:17330962 |
| Chain | Residue | Details |
| A | GLN92 | |
| B | GLN92 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27139 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER165 | |
| A | SER172 | |
| B | SER165 | |
| B | SER172 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 216 |
| Chain | Residue | Details |
| A | HIS64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS94 | metal ligand |
| A | HIS96 | metal ligand |
| A | GLU106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS119 | metal ligand |
| A | THR198 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 216 |
| Chain | Residue | Details |
| B | HIS64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS94 | metal ligand |
| B | HIS96 | metal ligand |
| B | GLU106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| B | HIS119 | metal ligand |
| B | THR198 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, increase nucleophilicity |
