5LVK
Human Lysozyme co-crystallized with [H2Ind][trans-RuCl4(DMSO)(HInd)]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006954 | biological_process | inflammatory response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0019730 | biological_process | antimicrobial humoral response |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1904724 | cellular_component | tertiary granule lumen |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006954 | biological_process | inflammatory response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0019730 | biological_process | antimicrobial humoral response |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0050830 | biological_process | defense response to Gram-positive bacterium |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1904724 | cellular_component | tertiary granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | ASN66 |
| A | SER80 |
| A | NA208 |
| A | HOH307 |
| A | HOH332 |
| A | HOH347 |
| B | THR43 |
| B | HOH323 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ASN88 |
| A | HOH319 |
| A | HOH323 |
| A | HOH342 |
| B | LYS1 |
| B | VAL2 |
| A | LYS69 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | TYR20 |
| A | LYS97 |
| B | ARG5 |
| B | LYS33 |
| B | HOH329 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | ASN60 |
| A | TRP64 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 206 |
| Chain | Residue |
| A | ARG119 |
| B | ARG122 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 207 |
| Chain | Residue |
| A | GLY127 |
| A | HOH389 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 208 |
| Chain | Residue |
| A | ASN66 |
| A | SO4201 |
| A | HOH332 |
| B | TYR45 |
| B | HOH323 |
| B | HOH403 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 209 |
| Chain | Residue |
| A | HOH335 |
| B | HOH330 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue RU B 201 |
| Chain | Residue |
| B | ARG107 |
| B | ARG113 |
| B | GLN117 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue RU B 202 |
| Chain | Residue |
| B | GLY127 |
| B | HOH407 |
| B | HOH425 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 203 |
| Chain | Residue |
| B | TRP64 |
| B | TRP109 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 204 |
| Chain | Residue |
| B | ASN88 |
| B | ALA90 |
| B | ASP91 |
| B | HOH345 |
| B | HOH356 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue NO3 B 205 |
| Chain | Residue |
| A | ARG122 |
| B | ARG119 |
Functional Information from PROSITE/UniProt
| site_id | PS00128 |
| Number of Residues | 19 |
| Details | GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. ChlsCsaLlqdNIadavaC |
| Chain | Residue | Details |
| A | CYS77-CYS95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 258 |
| Details | Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {} |
| Chain | Residue | Details |
