Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LU0

Crystal structure of H. pylori referent strain in complex with PO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue PO4 A 301

Chain	Residue
A	CYS19
A	GLY20
A	ARG24
A	ARG87
A	GLY89
A	THR90
A	TRS302
D	ARG43

site_id	AC2
Number of Residues	11
Details	binding site for residue TRS A 302

Chain	Residue
A	ARG87
A	THR90
A	PHE159
A	GLU179
A	MET180
A	GLU181
A	PO4301
A	HOH420
D	HIS4
D	ARG43
A	MET64

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS78
A	GLU191
A	HOH421
D	TYR160
D	PHE162

site_id	AC4
Number of Residues	8
Details	binding site for residue PO4 B 301

Chain	Residue
B	CYS19
B	GLY20
B	ARG24
B	ARG87
B	GLY89
B	THR90
B	TRS302
E	ARG43

site_id	AC5
Number of Residues	12
Details	binding site for residue TRS B 302

Chain	Residue
B	MET64
B	ARG87
B	THR90
B	PHE159
B	GLU179
B	MET180
B	GLU181
B	PO4301
B	HOH456
B	HOH474
E	HIS4
E	ARG43

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
B	LYS78
B	THR79
B	HOH413
C	ILE207
C	THR208
C	EDO303

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 304

Chain	Residue
B	LYS78
B	GLU191
C	EDO303
E	TYR160

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO B 305

Chain	Residue
B	LEU23
B	PRO214
B	HOH404
B	HOH414
B	HOH424
E	ASN6
E	HOH487

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO B 306

Chain	Residue
B	GLU38
B	ILE39
B	ASN41
B	HOH454

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO B 307

Chain	Residue
B	TYR27
B	LYS30
B	GLU219
B	HOH425
B	HOH431

site_id	AD2
Number of Residues	7
Details	binding site for residue PO4 C 301

Chain	Residue
C	GLY20
C	ARG24
C	ARG87
C	GLY89
C	THR90
C	TRS302
F	ARG43

site_id	AD3
Number of Residues	12
Details	binding site for residue TRS C 302

Chain	Residue
C	MET64
C	ARG87
C	THR90
C	PHE159
C	GLU179
C	MET180
C	GLU181
C	PO4301
C	HOH468
C	HOH556
F	HIS4
F	ARG43

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO C 303

Chain	Residue
B	THR74
B	LYS78
B	EDO303
B	EDO304
C	THR208
E	TYR160

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	HOH407
A	PHE162
A	HOH446
D	LYS78
D	GLU191

site_id	AD6
Number of Residues	8
Details	binding site for residue PO4 E 301

Chain	Residue
B	ARG43
E	CYS19
E	GLY20
E	ARG24
E	ARG87
E	GLY89
E	THR90
E	TRS302

site_id	AD7
Number of Residues	9
Details	binding site for residue TRS E 302

Chain	Residue
E	MET64
E	ARG87
E	THR90
E	ILE178
E	GLU179
E	MET180
E	GLU181
E	PO4301
E	HOH407

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO E 303

Chain	Residue
B	TYR160
B	PHE162
B	HOH422
E	LYS78
E	GLU191

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO F 301

Chain	Residue
C	PHE162
F	LYS78
F	GLU191

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiAScTIyvtEL

Chain	Residue	Details
A	GLY61-LEU76

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)