5LTI
Crystal structure of the alpha subunit of heme dependent oxidative N-demethylase (HODM) in complex with the dimethylamine substrate
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEM A 501 |
| Chain | Residue |
| A | TYR38 |
| A | PHE206 |
| A | ARG224 |
| A | ASN226 |
| A | TRP227 |
| A | PHE281 |
| A | TYR317 |
| A | LYS318 |
| A | DMN502 |
| A | NO503 |
| A | HOH625 |
| A | SER39 |
| A | HOH657 |
| A | LEU160 |
| A | TRP180 |
| A | PHE190 |
| A | TRP193 |
| A | HIS194 |
| A | VAL197 |
| A | VAL205 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue DMN A 502 |
| Chain | Residue |
| A | GLU266 |
| A | GLN268 |
| A | HEM501 |
| A | NO503 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NO A 503 |
| Chain | Residue |
| A | ARG224 |
| A | GLN268 |
| A | HEM501 |
| A | DMN502 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | MET37 |
| A | SER39 |
| A | NA505 |
| A | NA505 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 505 |
| Chain | Residue |
| A | PEG504 |
| A | PEG504 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"27851736","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27851736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LTI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"proximal binding residue","evidences":[{"source":"PubMed","id":"27851736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LTI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27851736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LTI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
