5LT6
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1801 |
| Chain | Residue |
| A | CYS1631 |
| A | CYS1678 |
| A | CYS1680 |
| A | CYS1685 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1802 |
| Chain | Residue |
| A | CYS1516 |
| A | CYS1529 |
| A | CYS1533 |
| A | CYS1539 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1803 |
| Chain | Residue |
| A | CYS1501 |
| A | CYS1516 |
| A | CYS1520 |
| A | CYS1499 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SCN A 1804 |
| Chain | Residue |
| A | MET1497 |
| A | CYS1499 |
| A | ASN1522 |
| A | CYS1529 |
| A | SER1530 |
| A | CYS1533 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue 76J A 1805 |
| Chain | Residue |
| A | LYS1560 |
| A | GLY1561 |
| A | TRP1562 |
| A | TYR1579 |
| A | TYR1605 |
| A | SER1624 |
| A | ARG1625 |
| A | ASN1628 |
| A | HIS1629 |
| A | PHE1664 |
| A | TYR1666 |
| A | GLN1676 |
| A | LYS1677 |
| A | CYS1678 |
| A | PHE1679 |
| A | LEU1689 |
| A | HOH1922 |
| A | HOH1928 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1801 |
| Chain | Residue |
| B | CYS1499 |
| B | CYS1501 |
| B | CYS1516 |
| B | CYS1520 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1802 |
| Chain | Residue |
| B | CYS1516 |
| B | CYS1529 |
| B | CYS1533 |
| B | CYS1539 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1803 |
| Chain | Residue |
| B | CYS1631 |
| B | CYS1678 |
| B | CYS1680 |
| B | CYS1685 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SCN B 1804 |
| Chain | Residue |
| B | MET1497 |
| B | GLN1498 |
| B | CYS1499 |
| B | ASN1522 |
| B | CYS1529 |
| B | SER1530 |
| B | CYS1533 |
| site_id | AD1 |
| Number of Residues | 19 |
| Details | binding site for residue 76J B 1805 |
| Chain | Residue |
| B | LYS1560 |
| B | GLY1561 |
| B | TRP1562 |
| B | TYR1579 |
| B | TYR1605 |
| B | SER1624 |
| B | ARG1625 |
| B | MET1627 |
| B | ASN1628 |
| B | HIS1629 |
| B | TYR1666 |
| B | GLN1669 |
| B | GLN1676 |
| B | LYS1677 |
| B | CYS1678 |
| B | PHE1679 |
| B | HOH1918 |
| B | HOH1940 |
| B | HOH1941 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
