5LT6
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0042054 | molecular_function | histone methyltransferase activity |
| B | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1801 |
| Chain | Residue |
| A | CYS1631 |
| A | CYS1678 |
| A | CYS1680 |
| A | CYS1685 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1802 |
| Chain | Residue |
| A | CYS1516 |
| A | CYS1529 |
| A | CYS1533 |
| A | CYS1539 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1803 |
| Chain | Residue |
| A | CYS1501 |
| A | CYS1516 |
| A | CYS1520 |
| A | CYS1499 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SCN A 1804 |
| Chain | Residue |
| A | MET1497 |
| A | CYS1499 |
| A | ASN1522 |
| A | CYS1529 |
| A | SER1530 |
| A | CYS1533 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue 76J A 1805 |
| Chain | Residue |
| A | LYS1560 |
| A | GLY1561 |
| A | TRP1562 |
| A | TYR1579 |
| A | TYR1605 |
| A | SER1624 |
| A | ARG1625 |
| A | ASN1628 |
| A | HIS1629 |
| A | PHE1664 |
| A | TYR1666 |
| A | GLN1676 |
| A | LYS1677 |
| A | CYS1678 |
| A | PHE1679 |
| A | LEU1689 |
| A | HOH1922 |
| A | HOH1928 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1801 |
| Chain | Residue |
| B | CYS1499 |
| B | CYS1501 |
| B | CYS1516 |
| B | CYS1520 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1802 |
| Chain | Residue |
| B | CYS1516 |
| B | CYS1529 |
| B | CYS1533 |
| B | CYS1539 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1803 |
| Chain | Residue |
| B | CYS1631 |
| B | CYS1678 |
| B | CYS1680 |
| B | CYS1685 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SCN B 1804 |
| Chain | Residue |
| B | MET1497 |
| B | GLN1498 |
| B | CYS1499 |
| B | ASN1522 |
| B | CYS1529 |
| B | SER1530 |
| B | CYS1533 |
| site_id | AD1 |
| Number of Residues | 19 |
| Details | binding site for residue 76J B 1805 |
| Chain | Residue |
| B | LYS1560 |
| B | GLY1561 |
| B | TRP1562 |
| B | TYR1579 |
| B | TYR1605 |
| B | SER1624 |
| B | ARG1625 |
| B | MET1627 |
| B | ASN1628 |
| B | HIS1629 |
| B | TYR1666 |
| B | GLN1669 |
| B | GLN1676 |
| B | LYS1677 |
| B | CYS1678 |
| B | PHE1679 |
| B | HOH1918 |
| B | HOH1940 |
| B | HOH1941 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625, ECO:0007744|PDB:4FMU, ECO:0007744|PDB:4H12, ECO:0007744|PDB:5JJY, ECO:0007744|PDB:5JLB, ECO:0007744|PDB:5JLE, ECO:0007744|PDB:5V21, ECO:0007744|PDB:5V22 |
| Chain | Residue | Details |
| A | CYS1499 | |
| A | CYS1680 | |
| A | CYS1685 | |
| B | CYS1499 | |
| B | CYS1501 | |
| B | CYS1516 | |
| B | CYS1520 | |
| B | CYS1529 | |
| B | CYS1533 | |
| B | CYS1539 | |
| B | CYS1631 | |
| A | CYS1501 | |
| B | CYS1678 | |
| B | CYS1680 | |
| B | CYS1685 | |
| A | CYS1516 | |
| A | CYS1520 | |
| A | CYS1529 | |
| A | CYS1533 | |
| A | CYS1539 | |
| A | CYS1631 | |
| A | CYS1678 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:28256625, ECO:0007744|PDB:4H12, ECO:0007744|PDB:5JJY, ECO:0007744|PDB:5JLB, ECO:0007744|PDB:5JLE, ECO:0007744|PDB:5V22 |
| Chain | Residue | Details |
| A | LYS1560 | |
| B | PHE1679 | |
| A | HIS1603 | |
| A | ASN1628 | |
| A | GLN1676 | |
| A | PHE1679 | |
| B | LYS1560 | |
| B | HIS1603 | |
| B | ASN1628 | |
| B | GLN1676 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER1696 | |
| B | SER1696 |
