5LRV
Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | HIS346 |
| A | ARG347 |
| B | VAL17 |
| B | GLU18 |
| B | ASP21 |
| B | LYS29 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ILE156 |
| A | GLN158 |
| A | HIS346 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ARG153 |
| A | GLN344 |
| B | ALA28 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLU152 |
| A | GLU339 |
| A | GLN344 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 505 |
| Chain | Residue |
| A | LEU318 |
| A | TYR354 |
| A | GLN356 |
| A | ALA357 |
| C | GLY35 |
| C | ILE36 |
| C | PRO37 |
| C | LEU73 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 | |
| C | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Regulatory loop","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12682062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14748687","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22179831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Stabilizes the conformation of the regulatory loop","evidences":[{"source":"PubMed","id":"27732584","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
