Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LRK

Crystal structure of the porcine carboxypeptidase B - Anabaenopeptin F complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0004181	molecular_function	metallocarboxypeptidase activity
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
C	0004181	molecular_function	metallocarboxypeptidase activity
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS69
A	GLU72
A	HIS196
F	73N1

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN B 401

Chain	Residue
B	HIS69
B	GLU72
B	HIS196
B	HOH529
G	73N1

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN C 401

Chain	Residue
C	HIS69
C	GLU72
C	HIS196
C	HOH552
H	73N1

site_id	AC4
Number of Residues	23
Details	binding site for Di-peptide 73N F 1 and DLY F 2

Chain	Residue
A	HIS69
A	ARG71
A	ARG127
A	ASN144
A	ARG145
A	TYR198
A	SER207
A	TYR248
A	ALA250
A	GLY253
A	ASP255
A	THR268
A	GLU270
A	PHE279
A	ZN401
A	HOH552
A	HOH598
A	HOH604
F	IIL3
F	73O4
F	MAA5
F	PHE6
F	HOH102

site_id	AC5
Number of Residues	14
Details	binding site for Di-peptide DLY F 2 and IIL F 3

Chain	Residue
A	ARG71
A	ARG127
A	ARG145
A	GLU163
A	THR164
A	TYR198
A	TYR248
A	PHE279
A	HOH552
F	73N1
F	73O4
F	MAA5
F	PHE6
F	HOH102

site_id	AC6
Number of Residues	11
Details	binding site for Di-peptide DLY F 2 and PHE F 6

Chain	Residue
A	ARG71
A	ARG127
A	TYR198
A	TYR248
A	PHE279
A	HOH552
F	73N1
F	IIL3
F	73O4
F	MAA5
F	HOH102

site_id	AC7
Number of Residues	12
Details	binding site for residues IIL F 3 and 73O F 4

Chain	Residue
A	ARG71
A	MET125
A	ARG127
A	ARG145
A	GLU163
A	THR164
A	TYR248
F	73N1
F	DLY2
F	MAA5
F	PHE6
F	HOH101

site_id	AC8
Number of Residues	7
Details	binding site for residues 73O F 4 and MAA F 5

Chain	Residue
A	ARG71
A	MET125
A	GLU163
F	DLY2
F	IIL3
F	PHE6
F	HOH101

site_id	AC9
Number of Residues	3
Details	binding site for Di-peptide MAA F 5 and PHE F 6

Chain	Residue
F	DLY2
F	IIL3
F	73O4

site_id	AD1
Number of Residues	25
Details	binding site for Di-peptide 73N G 1 and DLY G 2

Chain	Residue
B	HOH529
B	HOH558
B	HOH596
B	HOH640
B	HOH650
B	HOH704
G	IIL3
G	73O4
G	MAA5
G	PHE6
B	HIS69
B	ARG71
B	ARG127
B	ASN144
B	ARG145
B	TYR198
B	SER207
B	TYR248
B	ALA250
B	GLY253
B	ASP255
B	GLU270
B	PHE279
B	ZN401
B	HOH514

site_id	AD2
Number of Residues	15
Details	binding site for Di-peptide DLY G 2 and IIL G 3

Chain	Residue
B	ARG71
B	ARG127
B	ARG145
B	GLU163
B	TYR198
B	TYR248
B	PHE279
B	HOH514
B	HOH529
B	HOH596
B	HOH704
G	73N1
G	73O4
G	MAA5
G	PHE6

site_id	AD3
Number of Residues	15
Details	binding site for Di-peptide DLY G 2 and PHE G 6

Chain	Residue
B	ARG71
B	ARG127
B	TYR198
B	TYR248
B	PHE279
B	HOH514
B	HOH529
B	HOH596
B	HOH704
C	LEU308
G	73N1
G	IIL3
G	73O4
G	MAA5
G	HOH103

site_id	AD4
Number of Residues	14
Details	binding site for residues IIL G 3 and 73O G 4

Chain	Residue
B	GLU16
B	ARG71
B	MET125
B	ARG127
B	ARG145
B	GLU163
B	TYR248
B	HOH554
B	HOH620
G	73N1
G	DLY2
G	MAA5
G	PHE6
G	HOH101

site_id	AD5
Number of Residues	11
Details	binding site for residues 73O G 4 and MAA G 5

Chain	Residue
B	GLU16
B	ARG71
B	MET125
B	GLU163
B	HOH554
B	HOH620
G	DLY2
G	IIL3
G	PHE6
G	HOH101
G	HOH102

site_id	AD6
Number of Residues	6
Details	binding site for Di-peptide MAA G 5 and PHE G 6

Chain	Residue
C	LEU308
G	DLY2
G	IIL3
G	73O4
G	HOH102
G	HOH103

site_id	AD7
Number of Residues	21
Details	binding site for Di-peptide 73N H 1 and DLY H 2

Chain	Residue
C	HIS69
C	ARG71
C	ARG127
C	ASN144
C	ARG145
C	TYR198
C	SER207
C	TYR248
C	ALA250
C	GLY253
C	ASP255
C	GLU270
C	PHE279
C	ZN401
C	HOH552
C	HOH574
H	IIL3
H	73O4
H	MAA5
H	PHE6
H	HOH103

site_id	AD8
Number of Residues	12
Details	binding site for Di-peptide DLY H 2 and PHE H 6

Chain	Residue
C	ARG71
C	ARG127
C	TYR198
C	TYR248
C	PHE279
C	HOH552
H	73N1
H	IIL3
H	73O4
H	MAA5
H	HOH102
H	HOH103

site_id	AD9
Number of Residues	14
Details	binding site for Di-peptide DLY H 2 and IIL H 3

Chain	Residue
C	ARG71
C	ARG127
C	ARG145
C	GLU163
C	THR164
C	TYR198
C	TYR248
C	PHE279
C	HOH552
H	73N1
H	73O4
H	MAA5
H	PHE6
H	HOH103

site_id	AE1
Number of Residues	14
Details	binding site for residues IIL H 3 and 73O H 4

Chain	Residue
C	TRP15
C	GLU16
C	ARG71
C	MET125
C	ARG127
C	ARG145
C	GLU163
C	THR164
C	TYR248
H	73N1
H	DLY2
H	MAA5
H	PHE6
H	HOH101

site_id	AE2
Number of Residues	10
Details	binding site for residues 73O H 4 and MAA H 5

Chain	Residue
C	TRP15
C	GLU16
C	ARG71
C	MET125
C	GLU163
C	HOH770
H	DLY2
H	IIL3
H	PHE6
H	HOH101

site_id	AE3
Number of Residues	5
Details	binding site for Di-peptide MAA H 5 and PHE H 6

Chain	Residue
C	HOH770
H	DLY2
H	IIL3
H	73O4
H	HOH102

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PaIfMdcGfHArEwISHafcqwF

Chain	Residue	Details
A	PRO60-PHE82

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSYSQMIlYPY

Chain	Residue	Details
A	HIS196-TYR206

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	882
Details	Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details