5LQY

Structure of F-ATPase from Pichia angusta, in state2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
A	0006754	biological_process	ATP biosynthetic process
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
B	0006754	biological_process	ATP biosynthetic process
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
C	0006754	biological_process	ATP biosynthetic process
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0006754	biological_process	ATP biosynthetic process
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0006754	biological_process	ATP biosynthetic process
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
F	0006754	biological_process	ATP biosynthetic process
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006754	biological_process	ATP biosynthetic process
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006754	biological_process	ATP biosynthetic process
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0032780	biological_process	negative regulation of ATP-dependent activity
J	0042030	molecular_function	ATPase inhibitor activity
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006754	biological_process	ATP biosynthetic process
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006754	biological_process	ATP biosynthetic process
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	1902600	biological_process	proton transmembrane transport
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006754	biological_process	ATP biosynthetic process
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006754	biological_process	ATP biosynthetic process
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	1902600	biological_process	proton transmembrane transport
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006754	biological_process	ATP biosynthetic process
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006754	biological_process	ATP biosynthetic process
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006754	biological_process	ATP biosynthetic process
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006754	biological_process	ATP biosynthetic process
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006754	biological_process	ATP biosynthetic process
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006754	biological_process	ATP biosynthetic process
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
T	1902600	biological_process	proton transmembrane transport
U	0000274	cellular_component	mitochondrial proton-transporting ATP synthase, stator stalk
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006754	biological_process	ATP biosynthetic process
U	0015986	biological_process	proton motive force-driven ATP synthesis
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
U	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
U	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
U	1902600	biological_process	proton transmembrane transport
V	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006754	biological_process	ATP biosynthetic process
V	0015078	molecular_function	proton transmembrane transporter activity
V	0015986	biological_process	proton motive force-driven ATP synthesis
V	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
V	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
V	1902600	biological_process	proton transmembrane transport
W	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
W	0015078	molecular_function	proton transmembrane transporter activity
W	0015986	biological_process	proton motive force-driven ATP synthesis
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
Y	0006754	biological_process	ATP biosynthetic process
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0015986	biological_process	proton motive force-driven ATP synthesis
Y	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Y	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Y	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ATP A 600

Chain	Residue
A	ARG173
A	GLN174
A	THR178
A	ALA179
A	ARG364
A	PRO365
A	MG601

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 601

Chain	Residue
A	THR178
A	ATP600

---

site_id	AC3
Number of Residues	13
Details	binding site for residue ADP B 600

Chain	Residue
B	ASP172
B	ARG173
B	GLN174
B	THR175
B	GLY176
B	LYS177
B	THR178
B	ALA179
B	ARG364
B	GLN432
B	LYS433
B	GLN434
B	MG601

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG B 601

Chain	Residue
B	THR178
B	ADP600

---

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP C 600

Chain	Residue
C	ASP172
C	ARG173
C	GLN174
C	THR175
C	GLY176
C	LYS177
C	THR178
C	ALA179
C	ARG364
C	GLN432
C	LYS433
C	GLN434
C	MG601
F	ARG357

---

site_id	AC6
Number of Residues	2
Details	binding site for residue MG C 601

Chain	Residue
C	THR178
C	ADP600

---

site_id	AC7
Number of Residues	10
Details	binding site for residue ADP D 600

Chain	Residue
D	GLY159
D	ALA160
D	GLY161
D	VAL162
D	GLY163
D	LYS164
D	THR165
D	VAL166
D	TYR346
D	MG601

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG D 601

Chain	Residue
D	THR165
D	ADP600

---

site_id	AC9
Number of Residues	10
Details	binding site for residue ADP E 600

Chain	Residue
E	GLY159
E	ALA160
E	GLY161
E	VAL162
E	GLY163
E	LYS164
E	THR165
E	VAL166
E	TYR346
E	ALA422

---

site_id	AD1
Number of Residues	10
Details	binding site for residue ADP F 600

Chain	Residue
F	GLY159
F	ALA160
F	GLY161
F	VAL162
F	GLY163
F	LYS164
F	THR165
F	VAL166
F	TYR346
F	MG601

---

site_id	AD2
Number of Residues	2
Details	binding site for residue MG F 601

Chain	Residue
F	THR165
F	ADP600

---

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSKS

Chain	Residue	Details
D	PRO347-SER356
A	PRO365-SER374

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITnElvDiitGAsS

Chain	Residue	Details
G	ILE254-SER267

---

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLAANT

Chain	Residue	Details
Y	SER175-THR184

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPslrntLfPfaILgfaLsE

Chain	Residue	Details
K	SER38-GLU59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Participates in pH sensing

Chain	Residue	Details
J	GLU26
J	HIS49

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=aH3 => ECO:0000255

Chain	Residue	Details
Y	TYR88-VAL108

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=aH4 => ECO:0000255

Chain	Residue	Details
Y	LEU118-PHE138

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	TRANSMEM: Helical; Name=aH5 => ECO:0000305|PubMed:27791192

Chain	Residue	Details
Y	LEU157-LYS199

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	TRANSMEM: Helical; Name=aH6 => ECO:0000305|PubMed:27791192

Chain	Residue	Details
Y	ILE204-LYS246

---