5LOP
Structure of the active form of /K. lactis/ Dcp1-Dcp2-Edc3 decapping complex bound to m7GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0003723 | molecular_function | RNA binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0140933 | molecular_function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0000932 | cellular_component | P-body |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0031087 | biological_process | deadenylation-independent decapping of nuclear-transcribed mRNA |
| B | 0043085 | biological_process | positive regulation of catalytic activity |
| C | 0003723 | molecular_function | RNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ARG132 |
| A | GLU152 |
| A | MG302 |
| A | M7G303 |
| A | HOH404 |
| A | HOH407 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | MG301 |
| A | M7G303 |
| A | HOH401 |
| A | HOH402 |
| A | GLU148 |
| A | GLU152 |
| A | GLU197 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue M7G A 303 |
| Chain | Residue |
| A | TRP49 |
| A | ASP53 |
| A | LYS99 |
| A | ILE123 |
| A | ARG132 |
| A | GLY133 |
| A | LYS134 |
| A | GLU148 |
| A | GLU152 |
| A | HIS194 |
| A | LYS195 |
| A | ASN196 |
| A | GLU197 |
| A | MG301 |
| A | MG302 |
| A | MG304 |
| A | HOH401 |
| A | HOH403 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 304 |
| Chain | Residue |
| A | ARG147 |
| A | GLU148 |
| A | M7G303 |
| A | HOH401 |
| A | HOH403 |
| A | HOH406 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GkigkdEddvaCCiREVkEEtG |
| Chain | Residue | Details |
| A | GLY133-GLY154 |
