Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue HEC A 1001 |
| Chain | Residue |
| A | VAL19 |
| A | GLN51 |
| A | ARG60 |
| A | HIS62 |
| A | VAL64 |
| A | MET65 |
| A | TRP68 |
| A | LEU72 |
| A | VAL80 |
| A | GLN142 |
| A | TYR146 |
| A | CYS21 |
| A | GLN150 |
| A | HEC1002 |
| A | HOH1110 |
| A | CYS24 |
| A | HIS25 |
| A | LEU35 |
| A | GLY36 |
| A | ALA38 |
| A | LEU40 |
| A | TYR47 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue HEC A 1002 |
| Chain | Residue |
| A | TYR47 |
| A | GLN51 |
| A | ARG54 |
| A | CYS121 |
| A | CYS124 |
| A | HIS125 |
| A | VAL135 |
| A | PHE136 |
| A | PRO137 |
| A | LEU139 |
| A | TYR146 |
| A | LEU147 |
| A | TRP154 |
| A | ARG159 |
| A | GLU162 |
| A | MET167 |
| A | HEC1001 |
| A | HEC1004 |
| A | HOH1102 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue HEC A 1003 |
| Chain | Residue |
| A | THR286 |
| A | CYS287 |
| A | CYS290 |
| A | HIS291 |
| A | MET303 |
| A | ALA306 |
| A | TYR310 |
| A | MET323 |
| A | ARG326 |
| A | CYS330 |
| A | PHE331 |
| A | SER334 |
| A | ARG377 |
| A | TYR379 |
| A | TYR430 |
| A | THJ1008 |
| A | HOH1117 |
| A | HOH1153 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | binding site for residue HEC A 1004 |
| Chain | Residue |
| A | ARG123 |
| A | ARG269 |
| A | GLN285 |
| A | ALA288 |
| A | GLY289 |
| A | CYS290 |
| A | LEU292 |
| A | HIS401 |
| A | CYS402 |
| A | CYS405 |
| A | HIS406 |
| A | VAL420 |
| A | PHE421 |
| A | PRO422 |
| A | TYR430 |
| A | PHE445 |
| A | ILE446 |
| A | MET450 |
| A | PRO451 |
| A | LEU458 |
| A | ILE470 |
| A | HEC1002 |
| A | HOH1131 |
| A | HOH1135 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 1005 |
| Chain | Residue |
| A | TRP113 |
| A | ALA120 |
| A | ARG123 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1006 |
| Chain | Residue |
| A | HOH1139 |
| A | HOH1139 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue PGO A 1007 |
| Chain | Residue |
| A | ARG54 |
| A | GLY161 |
| A | PRO163 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue THJ A 1008 |
| Chain | Residue |
| A | ARG326 |
| A | GLY329 |
| A | CYS330 |
| A | TYR333 |
| A | SER334 |
| A | GLY435 |
| A | HEC1003 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 1009 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 1010 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 1011 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 1012 |
| Chain | Residue |
| A | GLY131 |
| A | GLY133 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 1013 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue PGO A 1014 |
| Chain | Residue |
| A | GLY155 |
| A | ALA171 |
| A | GLY172 |
| A | LEU174 |
| A | HOH1139 |
| A | HOH1139 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1015 |
| Chain | Residue |
| A | VAL135 |
| A | LEU404 |
| A | CYS405 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1016 |
| Chain | Residue |
| A | MET374 |
| A | GLY376 |
| A | ARG377 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 1017 |
| Chain | Residue |
| A | TYR310 |
| A | PRO311 |
| A | THR322 |
| A | MET323 |
| A | ALA324 |
| A | GLN357 |
| A | HOH1120 |
| B | TRP307 |
| B | GLN357 |
| B | HOH1131 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1018 |
| Chain | Residue |
| A | PRO114 |
| A | PHE244 |
| A | PRO246 |
| A | ARG296 |
| A | HOH1105 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1019 |
| Chain | Residue |
| A | ARG26 |
| A | ASP32 |
| A | GLU33 |
| A | ASN92 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1020 |
| Chain | Residue |
| A | GLN338 |
| A | SER340 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1021 |
| Chain | Residue |
| A | ARG249 |
| A | ASN294 |
| A | ARG296 |
| A | TYR359 |
| A | CL1010 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1022 |
| Chain | Residue |
| A | THR365 |
| B | GLY370 |
| site_id | AE5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1023 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1024 |
| Chain | Residue |
| A | ARG393 |
| A | HOH1104 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1025 |
| Chain | Residue |
| A | GLU325 |
| A | GLN328 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 1026 |
| Chain | Residue |
| A | TRP154 |
| A | ARG159 |
| A | HIS160 |
| A | HIS160 |
| A | GLY161 |
| A | GLU162 |
| A | GLY168 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 1005 |
| Chain | Residue |
| B | TRP113 |
| B | ALA120 |
| B | ARG123 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue THJ B 1006 |
| Chain | Residue |
| B | ARG326 |
| B | GLY329 |
| B | CYS330 |
| B | TYR333 |
| B | SER334 |
| B | GLY435 |
| B | HEC1003 |
| site_id | AF2 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 1007 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 1009 |
| Chain | Residue |
| B | ARG249 |
| B | ASN294 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue PGO B 1010 |
| Chain | Residue |
| B | ASP339 |
| B | PRO427 |
| B | ARG428 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue PGO B 1011 |
| Chain | Residue |
| B | PHE244 |
| B | PRO246 |
| B | ARG296 |
| B | ALA298 |
| B | HOH1122 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1012 |
| Chain | Residue |
| B | ARG381 |
| B | LEU382 |
| B | ASP440 |
| site_id | AF7 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC B 1001 and CYS B 47 |
| Chain | Residue |
| B | VAL19 |
| B | CYS21 |
| B | ALA22 |
| B | GLY23 |
| B | HIS25 |
| B | ARG26 |
| B | ASP32 |
| B | LEU35 |
| B | GLY36 |
| B | ALA37 |
| B | ALA38 |
| B | LEU40 |
| B | TYR47 |
| B | GLN51 |
| B | ARG60 |
| B | PRO63 |
| B | VAL64 |
| B | MET65 |
| B | TRP68 |
| B | VAL80 |
| B | TYR146 |
| B | GLN150 |
| B | HEC1002 |
| site_id | AF8 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC B 1001 and CYS B 44 |
| Chain | Residue |
| B | LEU8 |
| B | ALA9 |
| B | VAL19 |
| B | ALA20 |
| B | ALA22 |
| B | GLY23 |
| B | CYS24 |
| B | HIS25 |
| B | LEU35 |
| B | GLY36 |
| B | ALA38 |
| B | LEU40 |
| B | TYR47 |
| B | GLN51 |
| B | ARG60 |
| B | PRO63 |
| B | VAL64 |
| B | MET65 |
| B | TRP68 |
| B | VAL80 |
| B | TYR84 |
| B | TYR146 |
| B | GLN150 |
| B | HEC1002 |
| site_id | AF9 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide HEC B 1002 and CYS B 147 |
| Chain | Residue |
| B | TYR47 |
| B | GLN51 |
| B | ARG54 |
| B | CYS121 |
| B | VAL122 |
| B | ARG123 |
| B | HIS125 |
| B | GLY126 |
| B | ALA132 |
| B | VAL135 |
| B | PHE136 |
| B | PRO137 |
| B | LEU139 |
| B | TYR146 |
| B | LEU147 |
| B | TRP154 |
| B | ARG159 |
| B | GLU162 |
| B | MET167 |
| B | HEC1001 |
| site_id | AG1 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC B 1002 and CYS B 144 |
| Chain | Residue |
| B | TYR47 |
| B | GLN51 |
| B | ARG54 |
| B | LEU107 |
| B | ALA108 |
| B | PRO119 |
| B | ALA120 |
| B | VAL122 |
| B | ARG123 |
| B | CYS124 |
| B | HIS125 |
| B | VAL135 |
| B | PHE136 |
| B | PRO137 |
| B | LEU139 |
| B | TYR146 |
| B | LEU147 |
| B | TRP154 |
| B | ARG159 |
| B | GLU162 |
| B | MET167 |
| B | HEC1001 |
| site_id | AG2 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC B 1003 and CYS B 313 |
| Chain | Residue |
| B | THR286 |
| B | CYS287 |
| B | ALA288 |
| B | GLY289 |
| B | HIS291 |
| B | ALA300 |
| B | SER301 |
| B | MET303 |
| B | ALA306 |
| B | TYR310 |
| B | MET323 |
| B | ARG326 |
| B | CYS330 |
| B | PHE331 |
| B | SER334 |
| B | ARG377 |
| B | GLY378 |
| B | TYR379 |
| B | TYR430 |
| B | MET436 |
| B | THR441 |
| B | HEC1004 |
| B | THJ1006 |
| B | HOH1112 |
| site_id | AG3 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide HEC B 1003 and CYS B 310 |
| Chain | Residue |
| B | PHE268 |
| B | THR271 |
| B | THR286 |
| B | ALA288 |
| B | GLY289 |
| B | CYS290 |
| B | HIS291 |
| B | SER301 |
| B | MET303 |
| B | ALA306 |
| B | TYR310 |
| B | MET323 |
| B | ARG326 |
| B | CYS330 |
| B | PHE331 |
| B | SER334 |
| B | ARG377 |
| B | GLY378 |
| B | TYR379 |
| B | TYR430 |
| B | MET436 |
| B | THR441 |
| B | HEC1004 |
| B | THJ1006 |
| B | HOH1112 |
| site_id | AG4 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide HEC B 1004 and CYS B 428 |
| Chain | Residue |
| B | ARG123 |
| B | ARG269 |
| B | GLN285 |
| B | ALA288 |
| B | GLY289 |
| B | CYS290 |
| B | LEU292 |
| B | HIS401 |
| B | CYS402 |
| B | ALA403 |
| B | LEU404 |
| B | HIS406 |
| B | GLY407 |
| B | VAL420 |
| B | PHE421 |
| B | PRO422 |
| B | TYR430 |
| B | PHE445 |
| B | MET450 |
| B | PRO451 |
| B | HEC1003 |
| site_id | AG5 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide HEC B 1004 and CYS B 425 |
| Chain | Residue |
| B | ARG123 |
| B | ARG269 |
| B | GLN285 |
| B | ALA288 |
| B | GLY289 |
| B | CYS290 |
| B | LEU292 |
| B | TYR398 |
| B | HIS401 |
| B | ALA403 |
| B | LEU404 |
| B | CYS405 |
| B | HIS406 |
| B | VAL420 |
| B | PHE421 |
| B | PRO422 |
| B | TYR430 |
| B | PHE445 |
| B | MET450 |
| B | PRO451 |
| B | HEC1003 |
