5LN2

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 6ZT A 201

Chain	Residue
A	LEU54
A	HOH361
A	GLY58
A	TYR67
A	GLN72
A	VAL93
A	HIS96
A	ILE99
A	TYR100
A	HOH348

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site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 A 202

Chain	Residue
A	SER17
A	SER17
A	GLN18
A	ILE19
A	HIS96
A	HOH303
A	HOH308
A	HOH312
A	HOH336
A	HOH353

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site_id	AC3
Number of Residues	7
Details	binding site for residue CL A 203

Chain	Residue
A	LYS64
A	LYS64
A	ASP80
A	ASP80
A	LEU81
A	LEU81
A	HOH351

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