5LLT
Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with NaAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004515 | molecular_function | nicotinate-nucleotide adenylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0070566 | molecular_function | adenylyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004515 | molecular_function | nicotinate-nucleotide adenylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0070566 | molecular_function | adenylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue DND A 301 |
| Chain | Residue |
| A | TYR9 |
| A | ARG44 |
| A | LYS47 |
| A | GLU80 |
| A | PRO87 |
| A | THR88 |
| A | LEU108 |
| A | GLY109 |
| A | ASP111 |
| A | LEU112 |
| A | TRP119 |
| A | GLY10 |
| A | ASP120 |
| A | ARG136 |
| A | ILE163 |
| A | ASN164 |
| A | ILE166 |
| A | HOH410 |
| A | HOH414 |
| A | HOH417 |
| A | HOH419 |
| A | HOH423 |
| A | GLY11 |
| A | HOH424 |
| A | HOH435 |
| A | HOH439 |
| A | HOH441 |
| A | HOH443 |
| A | SER12 |
| A | PHE13 |
| A | ALA19 |
| A | HIS20 |
| A | VAL23 |
| A | CYS41 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 302 |
| Chain | Residue |
| A | SER118 |
| B | PHE139 |
| B | LYS140 |
| B | ILE141 |
| B | ASP142 |
| B | ILE145 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ASN64 |
| A | LYS71 |
| B | LEU79 |
| B | HOH428 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | LEU98 |
| A | HIS99 |
| A | ASN101 |
| B | TYR195 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | HIS82 |
| A | SER83 |
| B | SER72 |
| B | PHE75 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | ARG42 |
| A | GLU51 |
| A | PHE52 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | ARG42 |
| B | LYS71 |
| B | SER72 |
| site_id | AC8 |
| Number of Residues | 33 |
| Details | binding site for residue DND B 301 |
| Chain | Residue |
| B | TYR9 |
| B | GLY10 |
| B | GLY11 |
| B | SER12 |
| B | PHE13 |
| B | ALA19 |
| B | HIS20 |
| B | CYS41 |
| B | ARG44 |
| B | LYS47 |
| B | GLU80 |
| B | PRO87 |
| B | THR88 |
| B | LEU108 |
| B | GLY109 |
| B | ASP111 |
| B | LEU112 |
| B | TRP119 |
| B | ASP120 |
| B | ARG136 |
| B | ILE163 |
| B | ASN164 |
| B | ILE166 |
| B | PEG302 |
| B | HOH407 |
| B | HOH408 |
| B | HOH418 |
| B | HOH426 |
| B | HOH429 |
| B | HOH431 |
| B | HOH432 |
| B | HOH441 |
| B | HOH450 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 302 |
| Chain | Residue |
| B | ARG44 |
| B | LYS47 |
| B | ARG172 |
| B | DND301 |
| B | HOH437 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | LYS68 |
| B | ILE163 |
| B | TYR18 |
| B | GLU21 |
| B | ASP25 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| B | ASN29 |
| B | ASN31 |
| B | ILE70 |
| B | LYS73 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| B | TYR18 |
| B | PHE162 |
| B | LYS186 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 306 |
| Chain | Residue |
| A | ASN64 |
| A | ASN65 |
| B | TRP37 |
| B | LYS77 |
| B | LEU79 |
| B | GLN95 |
| B | LEU98 |
| B | HIS99 |
