5LJ2

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 5-(5-aminopyridin-3-yl)-8-(((3R,4R)-3-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)methoxy)piperidin-4-yl)amino)-3-methyl-1,7-naphthyridin-2(1H)-one

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 201

Chain	Residue
A	GLN123
A	ILE126
A	HOH304
A	HOH316
A	HOH333
A	HOH465

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 202

Chain	Residue
A	THR103
A	ASN135
A	HOH314
A	HOH319
A	ILE100
A	ILE101
A	LYS102

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 203

Chain	Residue
A	ILE138
A	GLN159
A	LYS160
A	HOH311

---

site_id	AC4
Number of Residues	16
Details	binding site for residue 6XW A 204

Chain	Residue
A	LYS57
A	ARG58
A	GLN59
A	TRP81
A	GLN85
A	LEU92
A	LYS99
A	ASN140
A	ASP144
A	ILE146
A	HOH302
A	HOH344
A	HOH349
A	HOH359
A	HOH419
A	HOH424

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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