Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LIV

Crystal structure of myxobacterial CYP260A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue HEM A 501

Chain	Residue
A	LEU123
A	GLY328
A	VAL329
A	ARG331
A	VAL382
A	PHE383
A	HIS388
A	CYS390
A	GOL502
A	HOH648
A	ALA124
A	HIS131
A	ARG135
A	GLY279
A	GLY280
A	THR283
A	THR284
A	SER325

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 502

Chain	Residue
A	GLY279
A	HEM501
A	GOL506

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 503

Chain	Residue
A	ARG95
A	LYS96
A	SER97
A	HOH602

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 504

Chain	Residue
A	ALA56
A	ASN57
C	HOH668

site_id	AC5
Number of Residues	3
Details	binding site for residue DMS A 505

Chain	Residue
A	HIS298
A	PRO299
A	ASP300

site_id	AC6
Number of Residues	1
Details	binding site for residue GOL A 506

Chain	Residue
A	GOL502

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 A 507

Chain	Residue
A	PHE389
A	ARG397
A	HOH627
A	HOH632
D	PRO376
D	LEU377

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 508

Chain	Residue
A	ARG171
A	LEU442
A	LEU443
A	HIS444

site_id	AC9
Number of Residues	6
Details	binding site for residue MES A 509

Chain	Residue
A	ARG104
A	ASP105
A	SO4510
A	SO4510
D	PRO365
D	SER366

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 A 510

Chain	Residue
A	MES509
A	MES509
A	HOH641

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 A 511

Chain	Residue
A	ALA167
A	ARG410
A	HIS444

site_id	AD3
Number of Residues	22
Details	binding site for residue HEM B 501

Chain	Residue
B	LEU123
B	ALA124
B	HIS131
B	ARG135
B	PHE142
B	LEU276
B	GLY279
B	GLY280
B	THR283
B	THR284
B	LEU287
B	GLY328
B	VAL329
B	ARG331
B	VAL382
B	PHE383
B	GLY384
B	HIS388
B	CYS390
B	VAL391
B	HOH602
B	HOH603

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 B 502

Chain	Residue
B	PRO376
B	LEU377
C	PHE389
C	ARG397

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG74
B	ARG95
B	LYS96
B	HOH630

site_id	AD6
Number of Residues	4
Details	binding site for residue GOL B 504

Chain	Residue
B	ALA379
B	ALA380
B	ARG397
C	LEU377

site_id	AD7
Number of Residues	2
Details	binding site for residue DMS B 505

Chain	Residue
B	ARG104
C	SER366

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 B 506

Chain	Residue
B	HIS298
B	PRO299
B	ASP300

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 B 507

Chain	Residue
B	ARG112
B	GLN115
B	GLN127

site_id	AE1
Number of Residues	22
Details	binding site for residue HEM C 501

Chain	Residue
C	GLY279
C	GLY280
C	THR283
C	LEU287
C	GLY328
C	VAL329
C	ARG331
C	VAL382
C	PHE383
C	GLY385
C	HIS388
C	CYS390
C	VAL391
C	GLY392
C	ALA396
C	GOL505
C	GOL506
C	HOH606
C	HOH681
C	ALA124
C	HIS131
C	ARG135

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 C 502

Chain	Residue
C	ARG112
C	GLN115
C	GLN127
C	HOH636

site_id	AE3
Number of Residues	3
Details	binding site for residue SO4 C 503

Chain	Residue
C	PRO81
C	ARG95
C	ASP341

site_id	AE4
Number of Residues	6
Details	binding site for residue GOL C 504

Chain	Residue
B	THR362
C	ARG74
C	ARG95
C	LYS96
C	SER97
C	HOH604

site_id	AE5
Number of Residues	3
Details	binding site for residue GOL C 505

Chain	Residue
C	LEU119
C	HEM501
C	GOL506

site_id	AE6
Number of Residues	5
Details	binding site for residue GOL C 506

Chain	Residue
C	LEU278
C	GLY279
C	THR283
C	HEM501
C	GOL505

site_id	AE7
Number of Residues	3
Details	binding site for residue DMS C 507

Chain	Residue
C	HIS298
C	PRO299
C	ASP300

site_id	AE8
Number of Residues	2
Details	binding site for residue SO4 C 508

Chain	Residue
B	ARG304
C	ARG136

site_id	AE9
Number of Residues	2
Details	binding site for residue SO4 C 509

Chain	Residue
C	ARG410
C	HIS445

site_id	AF1
Number of Residues	20
Details	binding site for residue HEM D 501

Chain	Residue
D	LEU123
D	ALA124
D	HIS131
D	ARG135
D	LEU276
D	GLY279
D	GLY280
D	THR283
D	LEU287
D	VAL329
D	ARG331
D	VAL382
D	PHE383
D	GLY384
D	HIS388
D	CYS390
D	VAL391
D	GOL502
D	GOL505
D	HOH627

site_id	AF2
Number of Residues	3
Details	binding site for residue GOL D 502

Chain	Residue
D	ALA124
D	HEM501
D	GOL505

site_id	AF3
Number of Residues	2
Details	binding site for residue DMS D 503

Chain	Residue
D	ARG304
D	DMS506

site_id	AF4
Number of Residues	3
Details	binding site for residue DMS D 504

Chain	Residue
D	ARG74
D	ARG95
D	LYS96

site_id	AF5
Number of Residues	4
Details	binding site for residue GOL D 505

Chain	Residue
D	GLY279
D	THR283
D	HEM501
D	GOL502

site_id	AF6
Number of Residues	2
Details	binding site for residue DMS D 506

Chain	Residue
A	ARG136
D	DMS503

site_id	AF7
Number of Residues	5
Details	binding site for residue GOL D 507

Chain	Residue
A	THR100
A	ARG104
A	GLY386
D	ARG374
D	LYS375

site_id	AF8
Number of Residues	3
Details	binding site for residue SO4 D 508

Chain	Residue
D	ALA167
D	ARG410
D	HIS444

site_id	AF9
Number of Residues	3
Details	binding site for residue SO4 D 509

Chain	Residue
D	ARG112
D	GLN115
D	GLN127

site_id	AG1
Number of Residues	3
Details	binding site for residue SO4 D 510

Chain	Residue
A	LEU377
D	PHE389
D	ARG397

site_id	AG2
Number of Residues	3
Details	binding site for residue SO4 D 511

Chain	Residue
C	ARG112
D	PRO54
D	LEU55

site_id	AG3
Number of Residues	3
Details	binding site for residue SO4 D 512

Chain	Residue
D	LEU442
D	LEU443
D	HIS444

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGAHFCVG

Chain	Residue	Details
A	PHE383-GLY392

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27878817","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29509407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29509407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5LIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"27878817","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29509407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LIV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6F8C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)