5LH9
Amine transaminase crystal structure from an uncultivated Pseudomonas species in the PLP-bound (internal aldimine) form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0016223 | molecular_function | beta-alanine:pyruvate transaminase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0016223 | molecular_function | beta-alanine:pyruvate transaminase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0016223 | molecular_function | beta-alanine:pyruvate transaminase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0008483 | molecular_function | transaminase activity |
| D | 0016223 | molecular_function | beta-alanine:pyruvate transaminase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue PLP A 1001 |
| Chain | Residue |
| A | GLY115 |
| A | LYS284 |
| A | HOH1125 |
| A | HOH1128 |
| A | HOH1158 |
| A | HOH1187 |
| A | HOH1221 |
| D | TYR320 |
| D | THR321 |
| A | SER116 |
| A | TYR148 |
| A | HIS149 |
| A | GLY150 |
| A | GLU222 |
| A | ASP255 |
| A | VAL257 |
| A | VAL258 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide PLP B 1001 and LYS B 284 |
| Chain | Residue |
| B | LEU53 |
| B | ASN55 |
| B | GLY114 |
| B | GLY115 |
| B | SER116 |
| B | TYR148 |
| B | HIS149 |
| B | GLY150 |
| B | GLU222 |
| B | ASP255 |
| B | VAL257 |
| B | VAL258 |
| B | ALA283 |
| B | GLY285 |
| B | ILE286 |
| B | THR287 |
| B | ALA288 |
| B | GLY289 |
| B | HOH1116 |
| B | HOH1125 |
| B | HOH1168 |
| B | HOH1191 |
| B | HOH1210 |
| C | TYR320 |
| C | THR321 |
| C | TYR322 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide PLP C 1001 and LYS C 284 |
| Chain | Residue |
| B | THR321 |
| B | TYR322 |
| C | LEU53 |
| C | ASN55 |
| C | GLY115 |
| C | SER116 |
| C | TYR148 |
| C | HIS149 |
| C | GLY150 |
| C | GLU222 |
| C | ASP255 |
| C | VAL257 |
| C | VAL258 |
| C | ALA283 |
| C | GLY285 |
| C | ILE286 |
| C | THR287 |
| C | ALA288 |
| C | GLY289 |
| C | HOH1128 |
| C | HOH1143 |
| C | HOH1170 |
| C | HOH1182 |
| C | HOH1198 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide PLP D 1001 and LYS D 284 |
| Chain | Residue |
| A | TYR320 |
| A | THR321 |
| A | TYR322 |
| D | LEU53 |
| D | ASN55 |
| D | GLY115 |
| D | SER116 |
| D | TYR148 |
| D | HIS149 |
| D | GLY150 |
| D | GLU222 |
| D | ASP255 |
| D | VAL257 |
| D | VAL258 |
| D | ALA283 |
| D | GLY285 |
| D | ILE286 |
| D | THR287 |
| D | ALA288 |
| D | GLY289 |
| D | HOH1121 |
| D | HOH1161 |
| D | HOH1166 |
| D | HOH1180 |
| D | HOH1193 |
Functional Information from PROSITE/UniProt
| site_id | PS00600 |
| Number of Residues | 38 |
| Details | AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. LIaDEVvt.GFgRsGcmlgsrgwgvap....DILclAKgitAG |
| Chain | Residue | Details |
| A | LEU252-GLY289 |
