5LG8

Human L-type ferritin iron loaded for 60 minutes

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0055072	biological_process	obsolete iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CD A 201

Chain	Residue
A	ASP15
A	ASP15
A	HOH432
A	HOH432
A	HOH445
A	HOH445

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CD A 202

Chain	Residue
A	ASP131
A	ASP131
A	ASP131

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CD A 203

Chain	Residue
A	CYS130
A	GLU134
A	GLU134

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CD A 204

Chain	Residue
A	HIS118
A	CYS130
A	GLU134
A	HOH484

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CD A 205

Chain	Residue
A	HIS136
A	HOH449
A	HOH464

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CD A 206

Chain	Residue
A	GLU90
A	HOH395
A	HOH416
A	HOH450

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CD A 207

Chain	Residue
A	GLU49
A	ASP178

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CD A 208

Chain	Residue
A	GLU90

---

site_id	AC9
Number of Residues	8
Details	binding site for residue FE A 209

Chain	Residue
A	GLU61
A	GLU64
A	FE210
A	FE211
A	OXY213
A	PER214
A	PER216
A	HOH383

---

site_id	AD1
Number of Residues	8
Details	binding site for residue FE A 210

Chain	Residue
A	GLU57
A	GLU60
A	GLU61
A	FE209
A	FE211
A	OXY213
A	PER215
A	PER216

---

site_id	AD2
Number of Residues	8
Details	binding site for residue FE A 211

Chain	Residue
A	GLU60
A	GLU64
A	FE209
A	FE210
A	OXY213
A	PER214
A	PER215
A	HOH382

---

site_id	AD3
Number of Residues	4
Details	binding site for residue FE A 212

Chain	Residue
A	GLU57
A	PER215
A	HOH457
A	HOH496

---

site_id	AD4
Number of Residues	9
Details	binding site for residue OXY A 213

Chain	Residue
A	GLU60
A	GLU61
A	GLU64
A	FE209
A	FE210
A	FE211
A	PER214
A	PER215
A	PER216

---

site_id	AD5
Number of Residues	6
Details	binding site for residue PER A 214

Chain	Residue
A	GLU64
A	FE209
A	FE211
A	OXY213
A	PER216
A	HOH383

---

site_id	AD6
Number of Residues	7
Details	binding site for residue PER A 215

Chain	Residue
A	GLU57
A	GLU60
A	FE210
A	FE211
A	FE212
A	OXY213
A	HOH388

---

site_id	AD7
Number of Residues	6
Details	binding site for residue PER A 216

Chain	Residue
A	GLU57
A	GLU61
A	FE209
A	FE210
A	OXY213
A	PER214

---

site_id	AD8
Number of Residues	9
Details	binding site for residue SO4 A 217

Chain	Residue
A	SER13
A	ASP15
A	ARG124
A	ARG124
A	HOH318
A	HOH327
A	HOH364
A	HOH415
A	HOH432

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEthFLdeevklIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgyERLLkmQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Catalytic site for iron oxidation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {}

Chain

Residue

Details

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