5LFY
Zinc bound dimer of the fragment of human amyloid-beta peptide with Alzheimer's disease pathogenic Taiwanese mutation D7H
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 101 |
| Chain | Residue |
| A | GLU3 |
| A | HIS7 |
| B | ASP1 |
| B | ALA2 |
| B | HIS6 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 102 |
| Chain | Residue |
| B | HIS7 |
| A | ASP1 |
| A | ALA2 |
| A | HIS6 |
| B | GLU3 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for Di-peptide TYR B 10 and NH2 B 11 |
| Chain | Residue |
| B | GLY9 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | HIS6 | |
| B | HIS6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| A | TYR10 | |
| B | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| A | ASP1 | |
| B | ASP1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| A | HIS7 | |
| B | HIS7 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | TYR10 | |
| B | TYR10 |
