5LF7

Human 20S proteasome complex with Ixazomib at 2.0 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0009615	biological_process	response to virus
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0098794	cellular_component	postsynapse
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0052548	biological_process	regulation of endopeptidase activity
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010243	biological_process	response to organonitrogen compound
J	0010498	biological_process	proteasomal protein catabolic process
J	0014070	biological_process	response to organic cyclic compound
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0010498	biological_process	proteasomal protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0098794	cellular_component	postsynapse
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0010498	biological_process	proteasomal protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0010498	biological_process	proteasomal protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0045202	cellular_component	synapse
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0052548	biological_process	regulation of endopeptidase activity
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0010498	biological_process	proteasomal protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0070062	cellular_component	extracellular exosome
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0070062	cellular_component	extracellular exosome
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010243	biological_process	response to organonitrogen compound
X	0010498	biological_process	proteasomal protein catabolic process
X	0014070	biological_process	response to organic cyclic compound
X	0016020	cellular_component	membrane
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	SER6
A	HOH473
C	ARG5
C	HOH418

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 302

Chain	Residue
A	ARG219

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 303

Chain	Residue
A	HIS87
A	ARG90
H	HOH465

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 304

Chain	Residue
A	HOH489
A	HOH472

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CL B 301

Chain	Residue
B	GLU70
B	GLN95
B	CL302
B	HOH495
I	HOH542

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 302

Chain	Residue
B	CL301
B	HOH462

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL C 301

Chain	Residue
C	ILE161
C	GLY162

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL C 302

Chain	Residue
C	ARG86
C	ARG117
C	HOH415

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CL D 301

Chain	Residue
D	ILE31
D	ILE170
D	GLY171
D	SER174
D	HOH427

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL D 302

Chain	Residue
D	THR161
D	HOH418
E	LEU77
E	THR78

---

site_id	AD2
Number of Residues	5
Details	binding site for residue CL E 301

Chain	Residue
E	6V1148
E	ILE161
E	GLY162
E	SER165
E	HOH514

---

site_id	AD3
Number of Residues	1
Details	binding site for residue CL E 302

Chain	Residue
E	SER150

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL E 303

Chain	Residue
E	GLY32
E	SER33
E	LYS62
E	GLY76

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CL F 301

Chain	Residue
F	VAL30
F	ILE165
F	GLY166
F	ARG169
F	HOH401
F	HOH458

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL G 301

Chain	Residue
G	HOH422
G	HOH519
N	HOH461

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CL G 302

Chain	Residue
G	LYS186
G	GLU192
G	GLN193
G	THR197

---

site_id	AD8
Number of Residues	5
Details	binding site for residue K G 303

Chain	Residue
G	THR14
G	TYR125
G	ASN128
G	MET131
G	HOH510

---

site_id	AD9
Number of Residues	6
Details	binding site for residue MG H 301

Chain	Residue
H	GLN92
H	HOH542
N	ASP94
N	HOH438
N	HOH489
N	HOH515

---

site_id	AE1
Number of Residues	5
Details	binding site for residue MG H 302

Chain	Residue
H	ILE164
H	ASP167
H	SER170
Z	ASP213
Z	HOH516

---

site_id	AE2
Number of Residues	4
Details	binding site for residue CL H 303

Chain	Residue
H	ASN81
H	ARG82
H	HOH524
N	HOH416

---

site_id	AE3
Number of Residues	6
Details	binding site for residue 1PE H 304

Chain	Residue
H	SER130
H	HOH460
N	THR23
Z	PHE33
a	TYR141
a	TYR144

---

site_id	AE4
Number of Residues	14
Details	binding site for residue 6V8 H 305

Chain	Residue
H	THR2
H	ALA21
H	THR22
H	GLU23
H	CYS32
H	ALA47
H	GLY48
H	THR49
H	ALA50
H	THR53
H	HOH415
H	HOH454
H	HOH472
I	ASP124

---

site_id	AE5
Number of Residues	5
Details	binding site for residue MG I 301

Chain	Residue
I	VAL174
I	ASP177
I	SER180
I	HOH442
I	HOH474

---

site_id	AE6
Number of Residues	2
Details	binding site for residue CL I 302

Chain	Residue
I	ARG65
I	ARG69

---

site_id	AE7
Number of Residues	3
Details	binding site for residue 1PE I 303

Chain	Residue
I	GLU96
I	LYS97
J	ASP90

---

site_id	AE8
Number of Residues	4
Details	binding site for residue 1PE I 304

Chain	Residue
H	LEU59
H	TYR91
I	TYR95
I	GLU96

---

site_id	AE9
Number of Residues	5
Details	binding site for residue MG I 305

Chain	Residue
I	ASP204
Y	THR165
Y	ASP168
Y	SER171
Y	HOH511

---

site_id	AF1
Number of Residues	6
Details	binding site for residue MG J 301

Chain	Residue
J	HOH412
J	HOH463
J	HOH466
J	HOH514
J	HOH528
K	HOH487

---

site_id	AF2
Number of Residues	5
Details	binding site for residue MG K 301

Chain	Residue
K	THR165
K	ASP168
K	SER171
W	ASP204
W	HOH460

---

site_id	AF3
Number of Residues	2
Details	binding site for residue CL K 302

Chain	Residue
K	LYS33
K	ASN176

---

site_id	AF4
Number of Residues	2
Details	binding site for residue CL K 303

Chain	Residue
K	TYR67
K	ARG70

---

site_id	AF5
Number of Residues	2
Details	binding site for residue CL K 304

Chain	Residue
K	ILE122
K	SER123

---

site_id	AF6
Number of Residues	9
Details	binding site for residue 6V8 K 305

Chain	Residue
K	THR2
K	ALA21
K	THR22
K	GLY48
K	ALA50
K	HOH410
K	HOH441
L	ASP125
L	HOH409

---

site_id	AF7
Number of Residues	4
Details	binding site for residue 1PE L 301

Chain	Residue
K	PHE55
L	SER98
L	PHE101
L	HOH478

---

site_id	AF8
Number of Residues	4
Details	binding site for residue K L 302

Chain	Residue
L	ALA183
L	ASP186
L	THR189
L	HOH480

---

site_id	AF9
Number of Residues	5
Details	binding site for residue MG L 303

Chain	Residue
L	ASP213
L	HOH482
V	ILE164
V	ASP167
V	SER170

---

site_id	AG1
Number of Residues	4
Details	binding site for residue CL M 301

Chain	Residue
M	ARG37
M	ASN38
M	ILE39
N	HOH440

---

site_id	AG2
Number of Residues	5
Details	binding site for residue CL M 302

Chain	Residue
M	ARG35
M	CL303
N	GLY98
N	GLY129
N	GLY130

---

site_id	AG3
Number of Residues	4
Details	binding site for residue CL M 303

Chain	Residue
M	TYR30
M	ARG35
M	CL302
N	MET117

---

site_id	AG4
Number of Residues	2
Details	binding site for residue CL M 304

Chain	Residue
M	ARG44
M	HOH448

---

site_id	AG5
Number of Residues	4
Details	binding site for residue 1PE M 305

Chain	Residue
L	PHE33
M	TYR141
M	TYR144
b	THR23

---

site_id	AG6
Number of Residues	4
Details	binding site for residue CL N 301

Chain	Residue
N	THR32
N	ARG46
N	GLN54
N	6V8305

---

site_id	AG7
Number of Residues	5
Details	binding site for residue CL N 302

Chain	Residue
N	ARG20
N	ARG30
N	GLY172
N	GLY173
a	HOH443

---

site_id	AG8
Number of Residues	8
Details	binding site for residue 1PE N 303

Chain	Residue
G	TYR103
H	PHE89
H	GLN92
N	TYR91
N	LEU95
N	HOH449
N	HOH480
N	HOH488

---

site_id	AG9
Number of Residues	5
Details	binding site for residue K N 304

Chain	Residue
N	MET165
N	ASP168
N	SER171
N	HOH512
N	HOH538

---

site_id	AH1
Number of Residues	14
Details	binding site for residue 6V8 N 305

Chain	Residue
H	TYR115
N	THR2
N	THR21
N	THR22
N	ALA28
N	ARG46
N	GLY48
N	ALA50
N	THR53
N	SER170
N	CL301
N	HOH431
N	HOH432
N	HOH483

---

site_id	AH2
Number of Residues	4
Details	binding site for residue CL O 301

Chain	Residue
O	SER6
O	PHE7
Q	ARG5
Q	HOH441

---

site_id	AH3
Number of Residues	1
Details	binding site for residue CL O 302

Chain	Residue
O	TYR100

---

site_id	AH4
Number of Residues	1
Details	binding site for residue CL O 303

Chain	Residue
O	ARG219

---

site_id	AH5
Number of Residues	1
Details	binding site for residue CL O 304

Chain	Residue
O	ARG90

---

site_id	AH6
Number of Residues	3
Details	binding site for residue CL P 301

Chain	Residue
P	GLU70
P	GLN95
P	HOH511

---

site_id	AH7
Number of Residues	3
Details	binding site for residue CL Q 301

Chain	Residue
Q	ARG95
Q	GLU99
Q	ASP100

---

site_id	AH8
Number of Residues	4
Details	binding site for residue CL Q 302

Chain	Residue
Q	VAL26
Q	ILE161
Q	GLY162
Q	HOH414

---

site_id	AH9
Number of Residues	6
Details	binding site for residue CL R 301

Chain	Residue
R	ILE31
R	ILE170
R	GLY171
R	SER174
R	HOH465
R	HOH507

---

site_id	AI1
Number of Residues	2
Details	binding site for residue CL R 302

Chain	Residue
R	THR161
S	THR78

---

site_id	AI2
Number of Residues	4
Details	binding site for residue CL S 301

Chain	Residue
S	ILE161
S	GLY162
S	SER165
S	HOH503

---

site_id	AI3
Number of Residues	2
Details	binding site for residue CL S 302

Chain	Residue
S	SER150
S	HOH449

---

site_id	AI4
Number of Residues	5
Details	binding site for residue CL S 303

Chain	Residue
S	GLY32
S	SER33
S	LYS62
S	ALA75
S	GLY76

---

site_id	AI5
Number of Residues	3
Details	binding site for residue CL U 301

Chain	Residue
U	HOH415
U	HOH476
b	HOH446

---

site_id	AI6
Number of Residues	5
Details	binding site for residue K U 302

Chain	Residue
U	THR14
U	TYR125
U	ASN128
U	MET131
U	HOH479

---

site_id	AI7
Number of Residues	8
Details	binding site for residue MG V 301

Chain	Residue
V	GLN92
V	HOH495
b	ASP52
b	ASP94
b	HOH406
b	HOH418
b	HOH426
b	HOH493

---

site_id	AI8
Number of Residues	2
Details	binding site for residue CL V 302

Chain	Residue
V	ASN81
V	ARG82

---

site_id	AI9
Number of Residues	5
Details	binding site for residue MG W 301

Chain	Residue
W	VAL174
W	ASP177
W	SER180
W	HOH453
W	HOH485

---

site_id	AJ1
Number of Residues	2
Details	binding site for residue CL W 302

Chain	Residue
W	ARG65
W	ARG69

---

site_id	AJ2
Number of Residues	3
Details	binding site for residue 1PE W 303

Chain	Residue
W	GLU96
W	LYS97
W	HOH449

---

site_id	AJ3
Number of Residues	6
Details	binding site for residue MG X 301

Chain	Residue
X	HOH410
X	HOH437
X	HOH464
X	HOH508
X	HOH523
Y	HOH504

---

site_id	AJ4
Number of Residues	3
Details	binding site for residue CL Y 301

Chain	Residue
Y	TYR67
Y	ARG70
Y	HOH514

---

site_id	AJ5
Number of Residues	2
Details	binding site for residue CL Y 302

Chain	Residue
Y	LYS33
Y	ASN176

---

site_id	AJ6
Number of Residues	2
Details	binding site for residue CL Y 303

Chain	Residue
Y	ILE122
Y	SER123

---

site_id	AJ7
Number of Residues	3
Details	binding site for residue CL Y 304

Chain	Residue
J	HOH434
Y	ASP155
Y	HOH493

---

site_id	AJ8
Number of Residues	5
Details	binding site for residue 1PE Y 305

Chain	Residue
Y	PHE55
Y	HOH460
Z	TYR97
Z	SER98
Z	PHE101

---

site_id	AJ9
Number of Residues	4
Details	binding site for residue K Z 301

Chain	Residue
Z	ALA183
Z	ASP186
Z	THR189
Z	HOH459

---

site_id	AK1
Number of Residues	5
Details	binding site for residue CL a 301

Chain	Residue
a	PHE36
a	ARG37
a	ASN38
a	ILE39
b	HOH485

---

site_id	AK2
Number of Residues	6
Details	binding site for residue CL a 302

Chain	Residue
a	ARG35
a	CL303
b	SER47
b	GLY98
b	GLY129
b	GLY130

---

site_id	AK3
Number of Residues	5
Details	binding site for residue CL a 303

Chain	Residue
a	TYR30
a	ARG35
a	CL302
b	PRO116
b	MET117

---

site_id	AK4
Number of Residues	1
Details	binding site for residue CL a 304

Chain	Residue
a	ARG44

---

site_id	AK5
Number of Residues	5
Details	binding site for residue CL b 301

Chain	Residue
M	HOH438
b	ARG20
b	ARG30
b	GLY172
b	GLY173

---

site_id	AK6
Number of Residues	3
Details	binding site for residue 1PE b 302

Chain	Residue
V	PHE89
b	TYR91
b	HOH511

---

site_id	AK7
Number of Residues	5
Details	binding site for residue K b 303

Chain	Residue
b	MET165
b	ASP168
b	SER171
b	HOH502
b	HOH508

---

site_id	AK8
Number of Residues	22
Details	binding site for Di-peptide 6V8 V 303 and THR V 2

Chain	Residue
V	THR3
V	ILE4
V	ASP18
V	ALA21
V	THR22
V	GLU23
V	CYS32
V	LYS34
V	ALA47
V	GLY48
V	THR49
V	ALA50
V	THR53
V	GLY129
V	SER130
V	GLY131
V	GLY169
V	SER170
V	HOH405
V	HOH437
V	HOH449
W	ASP124

---

site_id	AK9
Number of Residues	18
Details	binding site for Di-peptide 6V8 Y 306 and THR Y 2

Chain	Residue
Y	THR3
Y	ASP18
Y	ALA21
Y	THR22
Y	LYS34
Y	MET46
Y	ALA47
Y	GLY48
Y	ALA50
Y	GLY130
Y	SER131
Y	GLY132
Y	TYR170
Y	SER171
Y	HOH437
Y	HOH462
Z	ASP125
Z	HOH406

---

site_id	AL1
Number of Residues	20
Details	binding site for Di-peptide 6V8 b 304 and THR b 2

Chain	Residue
V	TYR115
b	THR3
b	ASP18
b	THR21
b	THR22
b	ALA28
b	LYS34
b	ARG46
b	SER47
b	GLY48
b	ALA50
b	THR53
b	GLY130
b	SER131
b	GLY132
b	SER170
b	SER171
b	HOH410
b	HOH417
b	HOH461

---

Functional Information from PROSITE/UniProt

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAIaGedFAIVASDtrlsegfsihtrdsp.KcykltdktvigcsGfhGD

Chain	Residue	Details
L	LEU13-ASP60
H	ALA5-ASP52
a	LEU12-ASP59
J	ILE5-ASP52
B	LEU35-ASP82
I	MET11-ASP58
b	MET5-ASP52
K	LEU5-ASP52

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA

Chain	Residue	Details
D	TYR8-ALA30
A	TYR5-ALA27
G	PHE9-ALA31
B	TYR5-ALA27
C	TYR3-ALA25
E	TYR6-ALA28
F	TYR7-ALA29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:25599644, ECO:0000269|PubMed:27493187

Chain	Residue	Details
N	THR2
b	THR2
L	SER134
Z	SER34
Z	SER40
Z	SER134

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	THR36
b	THR36
U	LYS102
U	LYS104
T	LYS205
T	LYS229

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS176
Z	LYS176
P	LYS127
P	LYS176
O	SER13
O	SER15

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
L	SER30
L	SER181
Z	SER30
Z	SER181

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
E	LYS115
R	SER63
E	LYS208
S	LYS115
S	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER198
R	SER198

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
A	TYR120
O	TYR120

---