5LF3

Human 20S proteasome complex with Bortezomib at 2.1 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006281	biological_process	DNA repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0008021	cellular_component	synaptic vesicle
A	0009615	biological_process	response to virus
A	0010498	biological_process	proteasomal protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030317	biological_process	flagellated sperm motility
A	0032729	biological_process	positive regulation of type II interferon production
A	0032743	biological_process	positive regulation of interleukin-2 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034341	biological_process	response to type II interferon
A	0034515	cellular_component	proteasome storage granule
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
A	0045061	biological_process	thymic T cell selection
A	0045063	biological_process	T-helper 1 cell differentiation
A	0045590	biological_process	negative regulation of regulatory T cell differentiation
A	0051321	biological_process	meiotic cell cycle
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	0071357	biological_process	cellular response to type I interferon
A	0072539	biological_process	T-helper 17 cell differentiation
A	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1990111	cellular_component	spermatoproteasome complex
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006281	biological_process	DNA repair
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0008021	cellular_component	synaptic vesicle
B	0010498	biological_process	proteasomal protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030317	biological_process	flagellated sperm motility
B	0032729	biological_process	positive regulation of type II interferon production
B	0032743	biological_process	positive regulation of interleukin-2 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0034341	biological_process	response to type II interferon
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
B	0045061	biological_process	thymic T cell selection
B	0045063	biological_process	T-helper 1 cell differentiation
B	0045590	biological_process	negative regulation of regulatory T cell differentiation
B	0051321	biological_process	meiotic cell cycle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	0071357	biological_process	cellular response to type I interferon
B	0072539	biological_process	T-helper 17 cell differentiation
B	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
B	1990111	cellular_component	spermatoproteasome complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	0000502	cellular_component	proteasome complex
C	0002376	biological_process	immune system process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006915	biological_process	apoptotic process
C	0006974	biological_process	DNA damage response
C	0006979	biological_process	response to oxidative stress
C	0008021	cellular_component	synaptic vesicle
C	0010498	biological_process	proteasomal protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030317	biological_process	flagellated sperm motility
C	0032729	biological_process	positive regulation of type II interferon production
C	0032743	biological_process	positive regulation of interleukin-2 production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034341	biological_process	response to type II interferon
C	0034515	cellular_component	proteasome storage granule
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
C	0045061	biological_process	thymic T cell selection
C	0045063	biological_process	T-helper 1 cell differentiation
C	0045590	biological_process	negative regulation of regulatory T cell differentiation
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0070062	cellular_component	extracellular exosome
C	0071357	biological_process	cellular response to type I interferon
C	0072539	biological_process	T-helper 17 cell differentiation
C	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	0000502	cellular_component	proteasome complex
D	0002376	biological_process	immune system process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007283	biological_process	spermatogenesis
D	0008021	cellular_component	synaptic vesicle
D	0010498	biological_process	proteasomal protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030317	biological_process	flagellated sperm motility
D	0032729	biological_process	positive regulation of type II interferon production
D	0032743	biological_process	positive regulation of interleukin-2 production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0034341	biological_process	response to type II interferon
D	0034515	cellular_component	proteasome storage granule
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
D	0045061	biological_process	thymic T cell selection
D	0045063	biological_process	T-helper 1 cell differentiation
D	0045590	biological_process	negative regulation of regulatory T cell differentiation
D	0051321	biological_process	meiotic cell cycle
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0071357	biological_process	cellular response to type I interferon
D	0072539	biological_process	T-helper 17 cell differentiation
D	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	1990111	cellular_component	spermatoproteasome complex
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006281	biological_process	DNA repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0008021	cellular_component	synaptic vesicle
E	0010498	biological_process	proteasomal protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0016604	cellular_component	nuclear body
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030317	biological_process	flagellated sperm motility
E	0032729	biological_process	positive regulation of type II interferon production
E	0032743	biological_process	positive regulation of interleukin-2 production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0034341	biological_process	response to type II interferon
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
E	0045061	biological_process	thymic T cell selection
E	0045063	biological_process	T-helper 1 cell differentiation
E	0045590	biological_process	negative regulation of regulatory T cell differentiation
E	0051321	biological_process	meiotic cell cycle
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	0071357	biological_process	cellular response to type I interferon
E	0072539	biological_process	T-helper 17 cell differentiation
E	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
E	1990111	cellular_component	spermatoproteasome complex
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	0000502	cellular_component	proteasome complex
F	0002376	biological_process	immune system process
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006281	biological_process	DNA repair
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0006915	biological_process	apoptotic process
F	0006974	biological_process	DNA damage response
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0008021	cellular_component	synaptic vesicle
F	0010498	biological_process	proteasomal protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030317	biological_process	flagellated sperm motility
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0032729	biological_process	positive regulation of type II interferon production
F	0032743	biological_process	positive regulation of interleukin-2 production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0034341	biological_process	response to type II interferon
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
F	0045061	biological_process	thymic T cell selection
F	0045063	biological_process	T-helper 1 cell differentiation
F	0045590	biological_process	negative regulation of regulatory T cell differentiation
F	0051321	biological_process	meiotic cell cycle
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0070062	cellular_component	extracellular exosome
F	0071357	biological_process	cellular response to type I interferon
F	0072539	biological_process	T-helper 17 cell differentiation
F	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
F	1990111	cellular_component	spermatoproteasome complex
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0002376	biological_process	immune system process
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0008021	cellular_component	synaptic vesicle
G	0010498	biological_process	proteasomal protein catabolic process
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0030317	biological_process	flagellated sperm motility
G	0032729	biological_process	positive regulation of type II interferon production
G	0032743	biological_process	positive regulation of interleukin-2 production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034341	biological_process	response to type II interferon
G	0034515	cellular_component	proteasome storage granule
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
G	0045061	biological_process	thymic T cell selection
G	0045063	biological_process	T-helper 1 cell differentiation
G	0045590	biological_process	negative regulation of regulatory T cell differentiation
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051321	biological_process	meiotic cell cycle
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0070062	cellular_component	extracellular exosome
G	0071357	biological_process	cellular response to type I interferon
G	0072539	biological_process	T-helper 17 cell differentiation
G	0097229	cellular_component	sperm end piece
G	0097542	cellular_component	ciliary tip
G	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
G	1990111	cellular_component	spermatoproteasome complex
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0002376	biological_process	immune system process
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006281	biological_process	DNA repair
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0008021	cellular_component	synaptic vesicle
I	0010498	biological_process	proteasomal protein catabolic process
I	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0030317	biological_process	flagellated sperm motility
I	0032729	biological_process	positive regulation of type II interferon production
I	0032743	biological_process	positive regulation of interleukin-2 production
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0034341	biological_process	response to type II interferon
I	0034515	cellular_component	proteasome storage granule
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
I	0045061	biological_process	thymic T cell selection
I	0045063	biological_process	T-helper 1 cell differentiation
I	0045590	biological_process	negative regulation of regulatory T cell differentiation
I	0051321	biological_process	meiotic cell cycle
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0061136	biological_process	regulation of proteasomal protein catabolic process
I	0070062	cellular_component	extracellular exosome
I	0071357	biological_process	cellular response to type I interferon
I	0072539	biological_process	T-helper 17 cell differentiation
I	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
I	1990111	cellular_component	spermatoproteasome complex
I	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
J	0000502	cellular_component	proteasome complex
J	0002376	biological_process	immune system process
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006281	biological_process	DNA repair
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0008021	cellular_component	synaptic vesicle
J	0010498	biological_process	proteasomal protein catabolic process
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0030317	biological_process	flagellated sperm motility
J	0032729	biological_process	positive regulation of type II interferon production
J	0032743	biological_process	positive regulation of interleukin-2 production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0034341	biological_process	response to type II interferon
J	0034515	cellular_component	proteasome storage granule
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
J	0045061	biological_process	thymic T cell selection
J	0045063	biological_process	T-helper 1 cell differentiation
J	0045590	biological_process	negative regulation of regulatory T cell differentiation
J	0051321	biological_process	meiotic cell cycle
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0061136	biological_process	regulation of proteasomal protein catabolic process
J	0070062	cellular_component	extracellular exosome
J	0071357	biological_process	cellular response to type I interferon
J	0072539	biological_process	T-helper 17 cell differentiation
J	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
J	1990111	cellular_component	spermatoproteasome complex
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0002376	biological_process	immune system process
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006281	biological_process	DNA repair
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006915	biological_process	apoptotic process
O	0006974	biological_process	DNA damage response
O	0006979	biological_process	response to oxidative stress
O	0007283	biological_process	spermatogenesis
O	0008021	cellular_component	synaptic vesicle
O	0009615	biological_process	response to virus
O	0010498	biological_process	proteasomal protein catabolic process
O	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0030317	biological_process	flagellated sperm motility
O	0032729	biological_process	positive regulation of type II interferon production
O	0032743	biological_process	positive regulation of interleukin-2 production
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0034341	biological_process	response to type II interferon
O	0034515	cellular_component	proteasome storage granule
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
O	0045061	biological_process	thymic T cell selection
O	0045063	biological_process	T-helper 1 cell differentiation
O	0045590	biological_process	negative regulation of regulatory T cell differentiation
O	0051321	biological_process	meiotic cell cycle
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0061136	biological_process	regulation of proteasomal protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	0071357	biological_process	cellular response to type I interferon
O	0072539	biological_process	T-helper 17 cell differentiation
O	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
O	1904813	cellular_component	ficolin-1-rich granule lumen
O	1990111	cellular_component	spermatoproteasome complex
O	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0002376	biological_process	immune system process
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006281	biological_process	DNA repair
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006915	biological_process	apoptotic process
P	0006974	biological_process	DNA damage response
P	0006979	biological_process	response to oxidative stress
P	0007283	biological_process	spermatogenesis
P	0008021	cellular_component	synaptic vesicle
P	0010498	biological_process	proteasomal protein catabolic process
P	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0030317	biological_process	flagellated sperm motility
P	0032729	biological_process	positive regulation of type II interferon production
P	0032743	biological_process	positive regulation of interleukin-2 production
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0034341	biological_process	response to type II interferon
P	0034515	cellular_component	proteasome storage granule
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
P	0045061	biological_process	thymic T cell selection
P	0045063	biological_process	T-helper 1 cell differentiation
P	0045590	biological_process	negative regulation of regulatory T cell differentiation
P	0051321	biological_process	meiotic cell cycle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0070062	cellular_component	extracellular exosome
P	0071357	biological_process	cellular response to type I interferon
P	0072539	biological_process	T-helper 17 cell differentiation
P	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
P	1990111	cellular_component	spermatoproteasome complex
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	0000502	cellular_component	proteasome complex
Q	0002376	biological_process	immune system process
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006281	biological_process	DNA repair
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0006915	biological_process	apoptotic process
Q	0006974	biological_process	DNA damage response
Q	0006979	biological_process	response to oxidative stress
Q	0008021	cellular_component	synaptic vesicle
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0030317	biological_process	flagellated sperm motility
Q	0032729	biological_process	positive regulation of type II interferon production
Q	0032743	biological_process	positive regulation of interleukin-2 production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0034341	biological_process	response to type II interferon
Q	0034515	cellular_component	proteasome storage granule
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
Q	0045061	biological_process	thymic T cell selection
Q	0045063	biological_process	T-helper 1 cell differentiation
Q	0045590	biological_process	negative regulation of regulatory T cell differentiation
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0071357	biological_process	cellular response to type I interferon
Q	0072539	biological_process	T-helper 17 cell differentiation
Q	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	0000502	cellular_component	proteasome complex
R	0002376	biological_process	immune system process
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006915	biological_process	apoptotic process
R	0006974	biological_process	DNA damage response
R	0006979	biological_process	response to oxidative stress
R	0007283	biological_process	spermatogenesis
R	0008021	cellular_component	synaptic vesicle
R	0010498	biological_process	proteasomal protein catabolic process
R	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0030317	biological_process	flagellated sperm motility
R	0032729	biological_process	positive regulation of type II interferon production
R	0032743	biological_process	positive regulation of interleukin-2 production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0034341	biological_process	response to type II interferon
R	0034515	cellular_component	proteasome storage granule
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
R	0045061	biological_process	thymic T cell selection
R	0045063	biological_process	T-helper 1 cell differentiation
R	0045590	biological_process	negative regulation of regulatory T cell differentiation
R	0051321	biological_process	meiotic cell cycle
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	0071357	biological_process	cellular response to type I interferon
R	0072539	biological_process	T-helper 17 cell differentiation
R	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
R	1904813	cellular_component	ficolin-1-rich granule lumen
R	1990111	cellular_component	spermatoproteasome complex
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006281	biological_process	DNA repair
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006915	biological_process	apoptotic process
S	0006974	biological_process	DNA damage response
S	0006979	biological_process	response to oxidative stress
S	0007283	biological_process	spermatogenesis
S	0008021	cellular_component	synaptic vesicle
S	0010498	biological_process	proteasomal protein catabolic process
S	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
S	0016604	cellular_component	nuclear body
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0030317	biological_process	flagellated sperm motility
S	0032729	biological_process	positive regulation of type II interferon production
S	0032743	biological_process	positive regulation of interleukin-2 production
S	0032760	biological_process	positive regulation of tumor necrosis factor production
S	0034341	biological_process	response to type II interferon
S	0034515	cellular_component	proteasome storage granule
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
S	0045061	biological_process	thymic T cell selection
S	0045063	biological_process	T-helper 1 cell differentiation
S	0045590	biological_process	negative regulation of regulatory T cell differentiation
S	0051321	biological_process	meiotic cell cycle
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0070062	cellular_component	extracellular exosome
S	0071357	biological_process	cellular response to type I interferon
S	0072539	biological_process	T-helper 17 cell differentiation
S	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
S	1990111	cellular_component	spermatoproteasome complex
S	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
T	0000502	cellular_component	proteasome complex
T	0002376	biological_process	immune system process
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006281	biological_process	DNA repair
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006915	biological_process	apoptotic process
T	0006974	biological_process	DNA damage response
T	0006979	biological_process	response to oxidative stress
T	0007283	biological_process	spermatogenesis
T	0008021	cellular_component	synaptic vesicle
T	0010498	biological_process	proteasomal protein catabolic process
T	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0030317	biological_process	flagellated sperm motility
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0032729	biological_process	positive regulation of type II interferon production
T	0032743	biological_process	positive regulation of interleukin-2 production
T	0032760	biological_process	positive regulation of tumor necrosis factor production
T	0034341	biological_process	response to type II interferon
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
T	0045061	biological_process	thymic T cell selection
T	0045063	biological_process	T-helper 1 cell differentiation
T	0045590	biological_process	negative regulation of regulatory T cell differentiation
T	0051321	biological_process	meiotic cell cycle
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0070062	cellular_component	extracellular exosome
T	0071357	biological_process	cellular response to type I interferon
T	0072539	biological_process	T-helper 17 cell differentiation
T	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
T	1990111	cellular_component	spermatoproteasome complex
T	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0002376	biological_process	immune system process
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006281	biological_process	DNA repair
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0006915	biological_process	apoptotic process
U	0006974	biological_process	DNA damage response
U	0006979	biological_process	response to oxidative stress
U	0007283	biological_process	spermatogenesis
U	0008021	cellular_component	synaptic vesicle
U	0010498	biological_process	proteasomal protein catabolic process
U	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0030317	biological_process	flagellated sperm motility
U	0032729	biological_process	positive regulation of type II interferon production
U	0032743	biological_process	positive regulation of interleukin-2 production
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0034341	biological_process	response to type II interferon
U	0034515	cellular_component	proteasome storage granule
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
U	0045061	biological_process	thymic T cell selection
U	0045063	biological_process	T-helper 1 cell differentiation
U	0045590	biological_process	negative regulation of regulatory T cell differentiation
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051321	biological_process	meiotic cell cycle
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	0071357	biological_process	cellular response to type I interferon
U	0072539	biological_process	T-helper 17 cell differentiation
U	0097229	cellular_component	sperm end piece
U	0097542	cellular_component	ciliary tip
U	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
U	1990111	cellular_component	spermatoproteasome complex
U	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0002376	biological_process	immune system process
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0006281	biological_process	DNA repair
W	0006915	biological_process	apoptotic process
W	0006974	biological_process	DNA damage response
W	0006979	biological_process	response to oxidative stress
W	0007283	biological_process	spermatogenesis
W	0008021	cellular_component	synaptic vesicle
W	0010498	biological_process	proteasomal protein catabolic process
W	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0030317	biological_process	flagellated sperm motility
W	0032729	biological_process	positive regulation of type II interferon production
W	0032743	biological_process	positive regulation of interleukin-2 production
W	0032760	biological_process	positive regulation of tumor necrosis factor production
W	0034341	biological_process	response to type II interferon
W	0034515	cellular_component	proteasome storage granule
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
W	0045061	biological_process	thymic T cell selection
W	0045063	biological_process	T-helper 1 cell differentiation
W	0045590	biological_process	negative regulation of regulatory T cell differentiation
W	0051321	biological_process	meiotic cell cycle
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0061136	biological_process	regulation of proteasomal protein catabolic process
W	0070062	cellular_component	extracellular exosome
W	0071357	biological_process	cellular response to type I interferon
W	0072539	biological_process	T-helper 17 cell differentiation
W	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
W	1990111	cellular_component	spermatoproteasome complex
W	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
X	0000502	cellular_component	proteasome complex
X	0002376	biological_process	immune system process
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0006281	biological_process	DNA repair
X	0006915	biological_process	apoptotic process
X	0006974	biological_process	DNA damage response
X	0006979	biological_process	response to oxidative stress
X	0007283	biological_process	spermatogenesis
X	0008021	cellular_component	synaptic vesicle
X	0010498	biological_process	proteasomal protein catabolic process
X	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
X	0016020	cellular_component	membrane
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0030317	biological_process	flagellated sperm motility
X	0032729	biological_process	positive regulation of type II interferon production
X	0032743	biological_process	positive regulation of interleukin-2 production
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0034341	biological_process	response to type II interferon
X	0034515	cellular_component	proteasome storage granule
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043374	biological_process	CD8-positive, alpha-beta T cell differentiation
X	0045061	biological_process	thymic T cell selection
X	0045063	biological_process	T-helper 1 cell differentiation
X	0045590	biological_process	negative regulation of regulatory T cell differentiation
X	0051321	biological_process	meiotic cell cycle
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0061136	biological_process	regulation of proteasomal protein catabolic process
X	0070062	cellular_component	extracellular exosome
X	0071357	biological_process	cellular response to type I interferon
X	0072539	biological_process	T-helper 17 cell differentiation
X	0160165	biological_process	CD8-positive, alpha-beta T cell homeostasis
X	1990111	cellular_component	spermatoproteasome complex
X	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	SER6
A	HOH436
C	ARG5
C	HOH413

---

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 302

Chain	Residue
A	ARG219

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 303

Chain	Residue
A	HIS87
A	ARG90

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL A 304

Chain	Residue
A	HOH460

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CL B 301

Chain	Residue
B	GLU70
B	GLN95
B	CL302
B	HOH506
I	HOH544
B	ASN69

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 302

Chain	Residue
B	CL301
B	HOH460

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL C 301

Chain	Residue
C	ILE161
C	GLY162
C	HOH411

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CL C 302

Chain	Residue
C	ARG86
C	LEU114
C	ARG117
C	HOH434

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL D 301

Chain	Residue
D	ILE31
D	LYS32
D	GLY171
D	SER174

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL D 302

Chain	Residue
D	THR161
D	HOH408
E	LEU77
E	THR78

---

site_id	AD2
Number of Residues	4
Details	binding site for residue CL E 301

Chain	Residue
E	ILE161
E	GLY162
E	SER165
E	HOH522

---

site_id	AD3
Number of Residues	1
Details	binding site for residue CL E 302

Chain	Residue
E	SER150

---

site_id	AD4
Number of Residues	4
Details	binding site for residue CL E 303

Chain	Residue
E	GLY32
E	SER33
E	LYS62
E	GLY76

---

site_id	AD5
Number of Residues	6
Details	binding site for residue CL F 301

Chain	Residue
F	VAL30
F	ILE165
F	GLY166
F	ARG169
F	HOH401
F	HOH481

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL G 301

Chain	Residue
G	HOH430
G	HOH510
N	HOH456

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CL G 302

Chain	Residue
G	LYS186
G	GLU192
G	GLN193
G	THR197

---

site_id	AD8
Number of Residues	5
Details	binding site for residue K G 303

Chain	Residue
G	THR14
G	TYR125
G	ASN128
G	MET131
G	HOH480

---

site_id	AD9
Number of Residues	7
Details	binding site for residue MG H 301

Chain	Residue
H	GLN91
H	HOH514
N	ASP93
N	HOH410
N	HOH421
N	HOH480
N	HOH501

---

site_id	AE1
Number of Residues	5
Details	binding site for residue MG H 302

Chain	Residue
H	ILE163
H	ASP166
H	SER169
H	HOH511
Z	ASP213

---

site_id	AE2
Number of Residues	5
Details	binding site for residue CL H 303

Chain	Residue
H	ASN80
H	ARG81
H	HOH531
H	HOH542
N	HOH468

---

site_id	AE3
Number of Residues	7
Details	binding site for residue 1PE H 304

Chain	Residue
G	TYR103
H	PHE88
H	GLN91
H	HOH415
H	HOH476
H	HOH493
N	TYR90

---

site_id	AE4
Number of Residues	5
Details	binding site for residue 1PE H 305

Chain	Residue
H	SER129
H	HOH475
N	THR22
Z	PHE33
a	TYR141

---

site_id	AE5
Number of Residues	11
Details	binding site for residue BO2 H 306

Chain	Residue
H	THR1
H	ALA20
H	THR21
H	GLU22
H	ALA46
H	GLY47
H	ALA49
H	HOH407
H	HOH413
H	HOH464
I	ASP124

---

site_id	AE6
Number of Residues	5
Details	binding site for residue MG I 301

Chain	Residue
I	ASP177
I	SER180
I	HOH428
I	HOH453
I	VAL174

---

site_id	AE7
Number of Residues	2
Details	binding site for residue CL I 302

Chain	Residue
I	ARG65
I	ARG69

---

site_id	AE8
Number of Residues	3
Details	binding site for residue 1PE I 303

Chain	Residue
I	GLU96
I	LYS97
J	ASP90

---

site_id	AE9
Number of Residues	4
Details	binding site for residue 1PE I 304

Chain	Residue
H	LEU58
H	TYR90
I	TYR95
I	GLU96

---

site_id	AF1
Number of Residues	5
Details	binding site for residue MG I 305

Chain	Residue
I	ASP204
Y	THR164
Y	ASP167
Y	SER170
Y	HOH505

---

site_id	AF2
Number of Residues	6
Details	binding site for residue MG J 301

Chain	Residue
J	HOH428
J	HOH438
J	HOH458
J	HOH520
J	HOH531
K	HOH490

---

site_id	AF3
Number of Residues	5
Details	binding site for residue MG K 301

Chain	Residue
K	THR164
K	ASP167
K	SER170
K	HOH471
W	ASP204

---

site_id	AF4
Number of Residues	3
Details	binding site for residue CL K 302

Chain	Residue
K	LYS32
K	ASN175
K	HOH501

---

site_id	AF5
Number of Residues	3
Details	binding site for residue CL K 303

Chain	Residue
K	TYR66
K	ARG69
K	HOH482

---

site_id	AF6
Number of Residues	2
Details	binding site for residue CL K 304

Chain	Residue
K	ILE121
K	SER122

---

site_id	AF7
Number of Residues	8
Details	binding site for residue BO2 K 305

Chain	Residue
K	THR1
K	ALA20
K	THR21
K	GLY47
K	ALA49
K	HOH415
K	HOH433
L	ASP125

---

site_id	AF8
Number of Residues	4
Details	binding site for residue 1PE L 301

Chain	Residue
K	PHE54
L	SER98
L	PHE101
L	HOH474

---

site_id	AF9
Number of Residues	4
Details	binding site for residue K L 302

Chain	Residue
L	ALA183
L	ASP186
L	THR189
L	HOH447

---

site_id	AG1
Number of Residues	5
Details	binding site for residue MG L 303

Chain	Residue
L	ASP213
V	ILE163
V	ASP166
V	SER169
V	HOH478

---

site_id	AG2
Number of Residues	5
Details	binding site for residue CL M 301

Chain	Residue
M	PHE36
M	ARG37
M	ASN38
N	HOH424
N	HOH512

---

site_id	AG3
Number of Residues	5
Details	binding site for residue CL M 302

Chain	Residue
M	ARG35
M	CL303
N	GLY97
N	GLY128
N	GLY129

---

site_id	AG4
Number of Residues	5
Details	binding site for residue CL M 303

Chain	Residue
M	TYR30
M	ARG35
M	CL302
N	PRO115
N	MET116

---

site_id	AG5
Number of Residues	1
Details	binding site for residue CL M 304

Chain	Residue
M	ARG44

---

site_id	AG6
Number of Residues	5
Details	binding site for residue 1PE M 305

Chain	Residue
L	PHE33
M	TYR141
M	HOH401
V	BO2303
b	THR22

---

site_id	AG7
Number of Residues	3
Details	binding site for residue CL N 301

Chain	Residue
N	THR31
N	ARG45
N	GLN53

---

site_id	AG8
Number of Residues	5
Details	binding site for residue CL N 302

Chain	Residue
N	ARG19
N	ARG29
N	GLY171
N	GLY172
a	HOH438

---

site_id	AG9
Number of Residues	6
Details	binding site for residue K N 303

Chain	Residue
N	MET164
N	ASP167
N	SER170
N	HOH452
N	HOH487
N	HOH543

---

site_id	AH1
Number of Residues	3
Details	binding site for residue CL O 301

Chain	Residue
O	SER6
Q	ARG5
Q	HOH433

---

site_id	AH2
Number of Residues	1
Details	binding site for residue CL O 302

Chain	Residue
O	TYR100

---

site_id	AH3
Number of Residues	2
Details	binding site for residue CL O 303

Chain	Residue
O	ARG218
O	ARG219

---

site_id	AH4
Number of Residues	3
Details	binding site for residue CL O 304

Chain	Residue
O	ARG90
U	LYS116
V	SER69

---

site_id	AH5
Number of Residues	4
Details	binding site for residue CL P 301

Chain	Residue
P	ASN69
P	GLU70
P	GLN95
P	HOH518

---

site_id	AH6
Number of Residues	2
Details	binding site for residue CL Q 301

Chain	Residue
Q	ARG95
Q	GLU99

---

site_id	AH7
Number of Residues	3
Details	binding site for residue CL Q 302

Chain	Residue
Q	VAL26
Q	ILE161
Q	GLY162

---

site_id	AH8
Number of Residues	5
Details	binding site for residue CL R 301

Chain	Residue
R	ILE31
R	ILE170
R	GLY171
R	SER174
R	HOH518

---

site_id	AH9
Number of Residues	2
Details	binding site for residue CL R 302

Chain	Residue
R	THR161
S	THR78

---

site_id	AI1
Number of Residues	4
Details	binding site for residue CL S 301

Chain	Residue
S	6V1148
S	ILE161
S	GLY162
S	SER165

---

site_id	AI2
Number of Residues	3
Details	binding site for residue CL S 302

Chain	Residue
S	SER150
S	ASN152
S	HOH402

---

site_id	AI3
Number of Residues	4
Details	binding site for residue CL S 303

Chain	Residue
S	GLY32
S	SER33
S	LYS62
S	GLY76

---

site_id	AI4
Number of Residues	3
Details	binding site for residue CL U 301

Chain	Residue
U	HOH428
U	HOH466
b	HOH467

---

site_id	AI5
Number of Residues	5
Details	binding site for residue K U 302

Chain	Residue
U	THR14
U	TYR125
U	ASN128
U	MET131
U	HOH453

---

site_id	AI6
Number of Residues	8
Details	binding site for residue MG V 301

Chain	Residue
V	GLN91
V	HOH486
b	ASP51
b	ASP93
b	HOH412
b	HOH414
b	HOH431
b	HOH486

---

site_id	AI7
Number of Residues	3
Details	binding site for residue CL V 302

Chain	Residue
V	ASN80
V	ARG81
b	HOH426

---

site_id	AI8
Number of Residues	5
Details	binding site for residue MG W 301

Chain	Residue
W	VAL174
W	ASP177
W	SER180
W	HOH458
W	HOH469

---

site_id	AI9
Number of Residues	2
Details	binding site for residue CL W 302

Chain	Residue
W	ARG65
W	ARG69

---

site_id	AJ1
Number of Residues	3
Details	binding site for residue 1PE W 303

Chain	Residue
W	GLU96
W	LYS97
W	HOH461

---

site_id	AJ2
Number of Residues	6
Details	binding site for residue MG X 301

Chain	Residue
X	HOH414
X	HOH438
X	HOH445
X	HOH506
X	HOH519
Y	HOH514

---

site_id	AJ3
Number of Residues	3
Details	binding site for residue CL Y 301

Chain	Residue
Y	TYR66
Y	ARG69
Y	HOH501

---

site_id	AJ4
Number of Residues	2
Details	binding site for residue CL Y 302

Chain	Residue
Y	LYS32
Y	ASN175

---

site_id	AJ5
Number of Residues	2
Details	binding site for residue CL Y 303

Chain	Residue
Y	ILE121
Y	SER122

---

site_id	AJ6
Number of Residues	4
Details	binding site for residue CL Y 304

Chain	Residue
J	HOH412
Y	ASP154
Y	LEU155
Y	HOH494

---

site_id	AJ7
Number of Residues	5
Details	binding site for residue 1PE Z 301

Chain	Residue
Y	PHE54
Z	TYR97
Z	SER98
Z	PHE101
Z	HOH1473

---

site_id	AJ8
Number of Residues	4
Details	binding site for residue K Z 302

Chain	Residue
Z	ALA183
Z	ASP186
Z	THR189
Z	HOH1444

---

site_id	AJ9
Number of Residues	5
Details	binding site for residue CL a 301

Chain	Residue
a	PHE36
a	ARG37
a	ASN38
a	ILE39
b	HOH444

---

site_id	AK1
Number of Residues	4
Details	binding site for residue CL a 302

Chain	Residue
a	ARG35
b	PRO115
b	MET116
b	CL301

---

site_id	AK2
Number of Residues	1
Details	binding site for residue CL a 303

Chain	Residue
a	ARG44

---

site_id	AK3
Number of Residues	7
Details	binding site for residue CL b 301

Chain	Residue
a	ARG35
a	CL302
b	SER46
b	GLY97
b	GLY128
b	GLY129
b	HOH490

---

site_id	AK4
Number of Residues	5
Details	binding site for residue CL b 302

Chain	Residue
M	HOH440
b	ARG19
b	ARG29
b	GLY171
b	GLY172

---

site_id	AK5
Number of Residues	5
Details	binding site for residue 1PE b 303

Chain	Residue
U	TYR103
V	ARG89
V	GLN91
b	LEU94
b	HOH516

---

site_id	AK6
Number of Residues	6
Details	binding site for residue K b 304

Chain	Residue
b	MET164
b	ASP167
b	SER170
b	HOH408
b	HOH452
b	HOH515

---

site_id	AK7
Number of Residues	14
Details	binding site for Ligand residues 6V1 E 148 through PRO E 149 bound to THR E 147

Chain	Residue
E	ALA25
E	MET26
E	VAL29
E	PRO127
E	TYR128
E	VAL130
E	GLN146
E	THR147
E	SER150
E	ALA151
E	ASN152
E	HOH449
E	HOH467
E	HOH486

---

site_id	AK8
Number of Residues	15
Details	binding site for Ligand residues 6V1 S 148 through PRO S 149 bound to THR S 147

Chain	Residue
S	ALA25
S	VAL29
S	LYS30
S	PRO127
S	TYR128
S	VAL130
S	GLN146
S	THR147
S	SER150
S	ALA151
S	ASN152
S	CL301
S	HOH433
S	HOH461
S	HOH462

---

site_id	AK9
Number of Residues	21
Details	binding site for Di-peptide BO2 N 304 and THR N 1

Chain	Residue
H	TYR114
H	SER118
N	THR2
N	ASP17
N	THR20
N	THR21
N	THR22
N	LYS33
N	ARG45
N	SER46
N	GLY47
N	ALA49
N	THR52
N	MET95
N	GLY129
N	SER130
N	GLY131
N	SER169
N	SER170
N	HOH443
N	HOH445

---

site_id	AL1
Number of Residues	20
Details	binding site for Di-peptide BO2 V 303 and THR V 1

Chain	Residue
M	1PE305
V	THR2
V	ILE3
V	ASP17
V	ALA20
V	THR21
V	GLU22
V	LYS33
V	ALA46
V	GLY47
V	ALA49
V	GLY128
V	SER129
V	GLY130
V	GLY168
V	SER169
V	HOH421
V	HOH424
W	ASP124
W	HOH426

---

site_id	AL2
Number of Residues	17
Details	binding site for Di-peptide BO2 Y 305 and THR Y 1

Chain	Residue
Y	THR2
Y	ASP17
Y	ALA20
Y	THR21
Y	LYS33
Y	MET45
Y	ALA46
Y	GLY47
Y	ALA49
Y	GLY129
Y	SER130
Y	GLY131
Y	TYR169
Y	SER170
Y	HOH404
Y	HOH443
Z	ASP125

---

site_id	AL3
Number of Residues	23
Details	binding site for Di-peptide BO2 b 305 and THR b 1

Chain	Residue
V	TYR114
V	SER118
V	HOH431
b	THR2
b	ASP17
b	THR20
b	THR21
b	THR22
b	LYS33
b	ARG45
b	SER46
b	GLY47
b	ALA49
b	THR52
b	MET95
b	GLY129
b	SER130
b	GLY131
b	SER169
b	SER170
b	HOH417
b	HOH422
b	HOH492

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA

Chain	Residue	Details
A	TYR5-ALA27
E	TYR6-ALA28
D	TYR8-ALA30
B	TYR5-ALA27
C	TYR3-ALA25
F	TYR7-ALA29
G	PHE9-ALA31

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFkFrhGVIVAADsratagayiasqtvk.KvieinpyllgtmaGgaAD

Chain	Residue	Details
K	LEU4-ASP51
L	LEU13-ASP60
I	MET11-ASP58
B	LEU35-ASP82
b	MET4-ASP51
J	ILE5-ASP52
H	ALA4-ASP51
a	LEU12-ASP59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	10
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---