5LEZ

Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0009615	biological_process	response to virus
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0052548	biological_process	regulation of endopeptidase activity
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0014070	biological_process	response to organic cyclic compound
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0045202	cellular_component	synapse
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0052548	biological_process	regulation of endopeptidase activity
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0070062	cellular_component	extracellular exosome
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0070062	cellular_component	extracellular exosome
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0014070	biological_process	response to organic cyclic compound
X	0016020	cellular_component	membrane
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue K G 301

Chain	Residue
G	THR14
G	TYR125
G	ASN128
G	MET131
G	HOH440

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG H 301

Chain	Residue
N	HOH412
N	HOH434
N	HOH435
H	GLN91
H	HOH454
H	HOH528
N	ASP51

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG H 302

Chain	Residue
H	ILE163
H	ASP166
H	SER169
Z	ASP213
Z	HOH504

---

site_id	AC4
Number of Residues	3
Details	binding site for residue 1PE H 303

Chain	Residue
H	TYR90
I	TYR95
I	GLU96

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG I 301

Chain	Residue
I	VAL174
I	ASP177
I	SER180
I	HOH405
I	HOH462

---

site_id	AC6
Number of Residues	4
Details	binding site for residue 1PE I 302

Chain	Residue
I	GLU96
I	LYS97
I	HOH504
J	ASP90

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG I 303

Chain	Residue
I	ASP204
I	HOH502
Y	THR164
Y	ASP167
Y	SER170

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG J 301

Chain	Residue
J	HOH404
J	HOH422
J	HOH448
J	HOH516
J	HOH529
K	HOH485

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MG K 301

Chain	Residue
K	THR164
K	ASP167
K	SER170
K	HOH451
W	ASP204

---

site_id	AD1
Number of Residues	3
Details	binding site for residue 1PE K 302

Chain	Residue
K	HOH491
L	SER98
L	PHE101

---

site_id	AD2
Number of Residues	1
Details	binding site for residue 1PE L 301

Chain	Residue
L	PHE33

---

site_id	AD3
Number of Residues	4
Details	binding site for residue K L 302

Chain	Residue
L	ALA183
L	ASP186
L	THR189
L	HOH436

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MG L 303

Chain	Residue
L	ASP213
V	ILE163
V	ASP166
V	SER169
V	HOH467

---

site_id	AD5
Number of Residues	4
Details	binding site for residue 1PE N 301

Chain	Residue
G	TYR103
H	GLN91
N	TYR90
N	HOH441

---

site_id	AD6
Number of Residues	5
Details	binding site for residue K N 302

Chain	Residue
N	MET164
N	ASP167
N	SER170
N	HOH516
N	HOH540

---

site_id	AD7
Number of Residues	4
Details	binding site for residue 1PE U 301

Chain	Residue
U	TYR103
U	HOH493
V	GLN91
b	LEU94

---

site_id	AD8
Number of Residues	5
Details	binding site for residue K U 302

Chain	Residue
U	THR14
U	TYR125
U	ASN128
U	MET131
U	HOH442

---

site_id	AD9
Number of Residues	7
Details	binding site for residue MG V 301

Chain	Residue
V	GLN91
V	HOH404
V	HOH482
b	ASP51
b	HOH409
b	HOH423
b	HOH438

---

site_id	AE1
Number of Residues	5
Details	binding site for residue MG W 301

Chain	Residue
W	VAL174
W	ASP177
W	SER180
W	HOH451
W	HOH464

---

site_id	AE2
Number of Residues	4
Details	binding site for residue 1PE W 302

Chain	Residue
W	GLU96
W	LYS97
W	HOH443
W	HOH459

---

site_id	AE3
Number of Residues	6
Details	binding site for residue MG X 301

Chain	Residue
X	HOH405
X	HOH406
X	HOH447
X	HOH509
X	HOH524
Y	HOH515

---

site_id	AE4
Number of Residues	5
Details	binding site for residue 1PE Y 301

Chain	Residue
Y	HOH466
Z	TYR97
Z	SER98
Z	PHE101
Y	HOH440

---

site_id	AE5
Number of Residues	4
Details	binding site for residue K Z 301

Chain	Residue
Z	ALA183
Z	ASP186
Z	THR189
Z	HOH429

---

site_id	AE6
Number of Residues	3
Details	binding site for residue 1PE a 301

Chain	Residue
N	THR22
a	HOH483
a	HOH501

---

site_id	AE7
Number of Residues	5
Details	binding site for residue K b 301

Chain	Residue
b	MET164
b	ASP167
b	SER170
b	HOH478
b	HOH497

---

site_id	AE8
Number of Residues	4
Details	binding site for residue ACT c 101

Chain	Residue
K	GLY47
K	GLY129
K	SER130
c	6VA4

---

site_id	AE9
Number of Residues	4
Details	binding site for residue ACT d 101

Chain	Residue
N	THR1
N	GLY129
N	SER130
d	6VA4

---

site_id	AF1
Number of Residues	3
Details	binding site for residue ACT e 101

Chain	Residue
Y	GLY129
Y	SER130
e	6VA4

---

site_id	AF2
Number of Residues	4
Details	binding site for residue ACT f 101

Chain	Residue
b	THR1
b	GLY129
b	SER130
f	6VA4

---

site_id	AF3
Number of Residues	16
Details	binding site for Ligand residues 6VA c 4 through 6V9 c 1 bound to THR K 1

Chain	Residue
K	THR1
K	ARG19
K	ALA20
K	THR21
K	VAL31
K	MET45
K	ALA46
K	GLY47
K	ALA49
K	SER130
K	TYR169
L	ASP125
L	VAL127
L	HOH409
c	ACT101
c	HOH201

---

site_id	AF4
Number of Residues	11
Details	binding site for Ligand 6VA c 4 bound to THR K 1

Chain	Residue
K	THR1
K	ARG19
K	VAL31
K	MET45
K	ALA46
K	GLY47
K	ALA49
K	SER130
K	TYR169
c	OAS3
c	ACT101

---

site_id	AF5
Number of Residues	17
Details	binding site for Ligand residues 6VA d 4 through 6V9 d 1 bound to THR N 1

Chain	Residue
H	TYR114
H	HIS116
N	THR1
N	ARG19
N	THR20
N	THR21
N	THR22
N	THR31
N	ARG45
N	SER46
N	GLY47
N	ALA49
N	SER130
N	SER169
N	HOH428
d	ACT101
d	HOH501

---

site_id	AF6
Number of Residues	13
Details	binding site for Ligand 6VA d 4 bound to THR N 1

Chain	Residue
N	THR1
N	ARG19
N	THR20
N	THR31
N	ARG45
N	SER46
N	GLY47
N	ALA49
N	SER130
N	SER169
N	HOH428
d	OAS3
d	ACT101

---

site_id	AF7
Number of Residues	16
Details	binding site for Ligand residues 6VA e 4 through 6V9 e 1 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	ALA20
Y	THR21
Y	VAL31
Y	MET45
Y	ALA46
Y	GLY47
Y	ALA49
Y	SER130
Y	TYR169
Z	ASP125
Z	VAL127
Z	HOH415
e	ACT101
e	HOH201

---

site_id	AF8
Number of Residues	11
Details	binding site for Ligand 6VA e 4 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	VAL31
Y	MET45
Y	ALA46
Y	GLY47
Y	ALA49
Y	SER130
Y	TYR169
e	OAS3
e	ACT101

---

site_id	AF9
Number of Residues	17
Details	binding site for Ligand residues 6VA f 4 through 6V9 f 1 bound to THR b 1

Chain	Residue
V	TYR114
V	HIS116
b	THR1
b	ARG19
b	THR20
b	THR21
b	THR22
b	THR31
b	ARG45
b	SER46
b	GLY47
b	ALA49
b	SER130
b	SER169
b	HOH408
f	ACT101
f	HOH201

---

site_id	AG1
Number of Residues	13
Details	binding site for Ligand 6VA f 4 bound to THR b 1

Chain	Residue
b	THR1
b	ARG19
b	THR20
b	THR31
b	ARG45
b	SER46
b	GLY47
b	ALA49
b	SER130
b	SER169
b	HOH408
f	OAS3
f	ACT101

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA

Chain	Residue	Details
F	TYR7-ALA29
D	TYR8-ALA30
A	TYR5-ALA27
C	TYR3-ALA25
E	TYR6-ALA28
B	TYR5-ALA27
G	PHE9-ALA31

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAIaGedFAIVASDtrlsegfsihtrdsp.KcykltdktvigcsGfhGD

Chain	Residue	Details
L	LEU13-ASP60
K	LEU4-ASP51
H	ALA4-ASP51
b	MET4-ASP51
I	MET11-ASP58
J	ILE5-ASP52
a	LEU12-ASP59
B	LEU35-ASP82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:25599644, ECO:0000269|PubMed:27493187

Chain	Residue	Details
N	THR1
b	THR1
L	SER134
Z	SER34
Z	SER40
Z	SER134

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	THR35
b	THR35
U	LYS102
U	LYS104
T	LYS205
T	LYS229

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS176
Z	LYS176
P	LYS127
P	LYS176
O	SER13
O	SER15

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
L	SER30
L	SER181
Z	SER30
Z	SER181

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
E	LYS115
R	SER63
E	LYS208
S	LYS115
S	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER198
R	SER198

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220

Chain	Residue	Details
A	TYR120
O	TYR120

---