Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LEY

Human 20S proteasome complex with Oprozomib at 1.9 Angstrom

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005839	cellular_component	proteasome core complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0009615	biological_process	response to virus
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0034774	cellular_component	secretory granule lumen
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
A	1904813	cellular_component	ficolin-1-rich granule lumen
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005839	cellular_component	proteasome core complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
C	0000502	cellular_component	proteasome complex
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034774	cellular_component	secretory granule lumen
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000502	cellular_component	proteasome complex
E	0001530	molecular_function	lipopolysaccharide binding
E	0002376	biological_process	immune system process
E	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
F	0000502	cellular_component	proteasome complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045202	cellular_component	synapse
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0052548	biological_process	regulation of endopeptidase activity
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005839	cellular_component	proteasome core complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0010498	biological_process	proteasomal protein catabolic process
J	0014070	biological_process	response to organic cyclic compound
J	0016020	cellular_component	membrane
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005839	cellular_component	proteasome core complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005839	cellular_component	proteasome core complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0005839	cellular_component	proteasome core complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005839	cellular_component	proteasome core complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0045202	cellular_component	synapse
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0052548	biological_process	regulation of endopeptidase activity
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0000932	cellular_component	P-body
U	0003723	molecular_function	RNA binding
U	0004175	molecular_function	endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0005840	cellular_component	ribosome
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0016363	cellular_component	nuclear matrix
U	0019773	cellular_component	proteasome core complex, alpha-subunit complex
U	0030016	cellular_component	myofibril
U	0030017	cellular_component	sarcomere
U	0035639	molecular_function	purine ribonucleoside triphosphate binding
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0050727	biological_process	regulation of inflammatory response
U	0051059	molecular_function	NF-kappaB binding
U	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0070062	cellular_component	extracellular exosome
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005839	cellular_component	proteasome core complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0070062	cellular_component	extracellular exosome
X	0000502	cellular_component	proteasome complex
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0010498	biological_process	proteasomal protein catabolic process
X	0014070	biological_process	response to organic cyclic compound
X	0016020	cellular_component	membrane
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005839	cellular_component	proteasome core complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0005839	cellular_component	proteasome core complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	SER6
A	HOH435
C	ARG5
C	HOH419

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 302

Chain	Residue
A	ARG219

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 303

Chain	Residue
A	HIS87
A	ARG90

site_id	AC4
Number of Residues	3
Details	binding site for residue CL A 304

Chain	Residue
A	HOH470
A	THR68
A	HOH453

site_id	AC5
Number of Residues	6
Details	binding site for residue CL B 301

Chain	Residue
B	ASN69
B	GLU70
B	GLN95
B	CL302
B	HOH495
I	HOH544

site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 302

Chain	Residue
B	CL301
B	HOH453

site_id	AC7
Number of Residues	1
Details	binding site for residue CL C 301

Chain	Residue
C	GLY162

site_id	AC8
Number of Residues	3
Details	binding site for residue CL C 302

Chain	Residue
C	ARG86
C	ARG117
C	HOH446

site_id	AC9
Number of Residues	4
Details	binding site for residue CL D 301

Chain	Residue
D	ILE31
D	ILE170
D	GLY171
D	SER174

site_id	AD1
Number of Residues	4
Details	binding site for residue CL D 302

Chain	Residue
D	THR161
E	LEU77
E	THR78
E	HOH464

site_id	AD2
Number of Residues	6
Details	binding site for residue CL E 301

Chain	Residue
E	LYS30
E	6V1148
E	ILE161
E	GLY162
E	SER165
E	HOH517

site_id	AD3
Number of Residues	2
Details	binding site for residue CL E 302

Chain	Residue
E	6V1148
E	SER150

site_id	AD4
Number of Residues	4
Details	binding site for residue CL E 303

Chain	Residue
E	GLY32
E	SER33
E	LYS62
E	GLY76

site_id	AD5
Number of Residues	6
Details	binding site for residue CL F 301

Chain	Residue
F	VAL30
F	ILE165
F	GLY166
F	ARG169
F	HOH401
F	HOH452

site_id	AD6
Number of Residues	3
Details	binding site for residue CL G 301

Chain	Residue
G	HOH427
G	HOH440
N	HOH418

site_id	AD7
Number of Residues	4
Details	binding site for residue CL G 302

Chain	Residue
G	LYS186
G	GLU192
G	GLN193
G	THR197

site_id	AD8
Number of Residues	5
Details	binding site for residue K G 303

Chain	Residue
G	THR14
G	TYR125
G	ASN128
G	MET131
G	HOH462

site_id	AD9
Number of Residues	7
Details	binding site for residue MG H 301

Chain	Residue
H	GLN91
H	HOH465
H	HOH511
N	ASP51
N	HOH405
N	HOH417
N	HOH490

site_id	AE1
Number of Residues	5
Details	binding site for residue MG H 302

Chain	Residue
H	ILE163
H	ASP166
H	SER169
H	HOH484
Z	ASP213

site_id	AE2
Number of Residues	3
Details	binding site for residue CL H 303

Chain	Residue
H	GLY128
H	SER129
H	HOH542

site_id	AE3
Number of Residues	3
Details	binding site for residue CL H 304

Chain	Residue
H	ASN80
H	ARG81
H	HOH521

site_id	AE4
Number of Residues	7
Details	binding site for residue 1PE H 305

Chain	Residue
G	TYR103
H	PHE88
H	GLN91
H	HOH436
H	HOH442
H	HOH479
N	TYR90

site_id	AE5
Number of Residues	3
Details	binding site for residue 1PE H 306

Chain	Residue
H	SER129
H	HOH473
N	THR22

site_id	AE6
Number of Residues	5
Details	binding site for residue MG I 301

Chain	Residue
I	VAL174
I	ASP177
I	SER180
I	HOH404
I	HOH492

site_id	AE7
Number of Residues	2
Details	binding site for residue CL I 302

Chain	Residue
I	ARG65
I	ARG69

site_id	AE8
Number of Residues	3
Details	binding site for residue 1PE I 303

Chain	Residue
I	GLU96
I	LYS97
J	ASP90

site_id	AE9
Number of Residues	3
Details	binding site for residue 1PE I 304

Chain	Residue
H	TYR90
I	TYR95
H	LEU58

site_id	AF1
Number of Residues	5
Details	binding site for residue MG I 305

Chain	Residue
I	ASP204
Y	THR164
Y	ASP167
Y	SER170
Y	HOH479

site_id	AF2
Number of Residues	6
Details	binding site for residue MG J 301

Chain	Residue
J	HOH409
J	HOH449
J	HOH468
J	HOH512
J	HOH527
K	HOH486

site_id	AF3
Number of Residues	5
Details	binding site for residue MG K 301

Chain	Residue
K	THR164
K	ASP167
K	SER170
K	HOH462
W	ASP204

site_id	AF4
Number of Residues	3
Details	binding site for residue CL K 302

Chain	Residue
K	GLY129
K	SER130
c	6VA4

site_id	AF5
Number of Residues	2
Details	binding site for residue CL K 303

Chain	Residue
K	LYS32
K	ASN175

site_id	AF6
Number of Residues	3
Details	binding site for residue CL K 304

Chain	Residue
K	TYR66
K	ARG69
K	HOH445

site_id	AF7
Number of Residues	2
Details	binding site for residue CL K 305

Chain	Residue
K	ILE121
K	SER122

site_id	AF8
Number of Residues	4
Details	binding site for residue 1PE L 301

Chain	Residue
K	PHE54
L	SER98
L	PHE101
L	HOH452

site_id	AF9
Number of Residues	4
Details	binding site for residue K L 302

Chain	Residue
L	ALA183
L	ASP186
L	THR189
L	HOH472

site_id	AG1
Number of Residues	5
Details	binding site for residue MG L 303

Chain	Residue
L	ASP213
V	ILE163
V	ASP166
V	SER169
V	HOH473

site_id	AG2
Number of Residues	4
Details	binding site for residue CL M 301

Chain	Residue
M	PHE36
M	ARG37
M	ASN38
N	HOH493

site_id	AG3
Number of Residues	6
Details	binding site for residue CL M 302

Chain	Residue
M	ARG35
M	CL303
N	SER46
N	GLY97
N	GLY128
N	GLY129

site_id	AG4
Number of Residues	5
Details	binding site for residue CL M 303

Chain	Residue
M	TYR30
M	ARG35
M	CL302
N	PRO115
N	MET116

site_id	AG5
Number of Residues	1
Details	binding site for residue CL M 304

Chain	Residue
M	ARG44

site_id	AG6
Number of Residues	3
Details	binding site for residue 1PE M 305

Chain	Residue
M	TYR144
V	SER129
b	THR22

site_id	AG7
Number of Residues	3
Details	binding site for residue CL N 301

Chain	Residue
N	THR31
N	ARG45
N	GLN53

site_id	AG8
Number of Residues	3
Details	binding site for residue CL N 302

Chain	Residue
N	THR1
N	GLY129
N	SER130

site_id	AG9
Number of Residues	5
Details	binding site for residue CL N 303

Chain	Residue
N	ARG19
N	ARG29
N	GLY171
N	GLY172
a	HOH438

site_id	AH1
Number of Residues	5
Details	binding site for residue K N 304

Chain	Residue
N	MET164
N	ASP167
N	SER170
N	HOH472
N	HOH543

site_id	AH2
Number of Residues	4
Details	binding site for residue CL O 301

Chain	Residue
O	SER6
O	PHE7
Q	ARG5
Q	HOH440

site_id	AH3
Number of Residues	1
Details	binding site for residue CL O 302

Chain	Residue
O	TYR100

site_id	AH4
Number of Residues	2
Details	binding site for residue CL O 303

Chain	Residue
O	ARG218
O	ARG219

site_id	AH5
Number of Residues	2
Details	binding site for residue CL O 304

Chain	Residue
O	HIS87
O	ARG90

site_id	AH6
Number of Residues	4
Details	binding site for residue CL P 301

Chain	Residue
P	ASN69
P	GLU70
P	GLN95
P	HOH507

site_id	AH7
Number of Residues	1
Details	binding site for residue CL Q 301

Chain	Residue
Q	ARG95

site_id	AH8
Number of Residues	3
Details	binding site for residue CL Q 302

Chain	Residue
Q	ILE161
Q	GLY162
Q	HOH408

site_id	AH9
Number of Residues	6
Details	binding site for residue CL R 301

Chain	Residue
R	ILE31
R	ILE170
R	GLY171
R	SER174
R	HOH453
R	HOH506

site_id	AI1
Number of Residues	3
Details	binding site for residue CL R 302

Chain	Residue
R	THR161
R	HOH446
S	THR78

site_id	AI2
Number of Residues	4
Details	binding site for residue CL S 301

Chain	Residue
S	ILE161
S	GLY162
S	SER165
S	HOH503

site_id	AI3
Number of Residues	3
Details	binding site for residue CL S 302

Chain	Residue
S	SER150
S	ASN152
S	HOH401

site_id	AI4
Number of Residues	5
Details	binding site for residue CL S 303

Chain	Residue
S	GLY32
S	SER33
S	LYS62
S	ALA75
S	GLY76

site_id	AI5
Number of Residues	4
Details	binding site for residue CL U 301

Chain	Residue
U	LYS102
U	HOH429
U	HOH434
b	HOH424

site_id	AI6
Number of Residues	5
Details	binding site for residue K U 302

Chain	Residue
U	THR14
U	TYR125
U	ASN128
U	MET131
U	HOH463

site_id	AI7
Number of Residues	7
Details	binding site for residue MG V 301

Chain	Residue
V	GLN91
V	HOH462
V	HOH470
b	ASP93
b	HOH412
b	HOH425
b	HOH441

site_id	AI8
Number of Residues	2
Details	binding site for residue CL V 302

Chain	Residue
V	GLY128
V	SER129

site_id	AI9
Number of Residues	2
Details	binding site for residue CL V 303

Chain	Residue
V	ASN80
V	ARG81

site_id	AJ1
Number of Residues	5
Details	binding site for residue 1PE V 304

Chain	Residue
U	TYR103
V	ARG89
V	GLN91
V	HOH499
b	TYR61

site_id	AJ2
Number of Residues	5
Details	binding site for residue MG W 301

Chain	Residue
W	VAL174
W	ASP177
W	SER180
W	HOH455
W	HOH459

site_id	AJ3
Number of Residues	2
Details	binding site for residue CL W 302

Chain	Residue
W	ARG65
W	ARG69

site_id	AJ4
Number of Residues	4
Details	binding site for residue 1PE W 303

Chain	Residue
W	GLU96
W	LYS97
W	HOH462
X	ASP90

site_id	AJ5
Number of Residues	6
Details	binding site for residue MG X 301

Chain	Residue
X	HOH409
X	HOH440
X	HOH441
X	HOH509
X	HOH519
Y	HOH509

site_id	AJ6
Number of Residues	3
Details	binding site for residue CL Y 301

Chain	Residue
Y	GLY129
Y	SER130
d	6VA4

site_id	AJ7
Number of Residues	3
Details	binding site for residue CL Y 302

Chain	Residue
Y	TYR66
Y	ARG69
Y	HOH498

site_id	AJ8
Number of Residues	2
Details	binding site for residue CL Y 303

Chain	Residue
Y	LYS32
Y	ASN175

site_id	AJ9
Number of Residues	2
Details	binding site for residue CL Y 304

Chain	Residue
Y	ILE121
Y	SER122

site_id	AK1
Number of Residues	3
Details	binding site for residue CL Y 305

Chain	Residue
Y	ASP154
Y	LEU155
Y	HOH486

site_id	AK2
Number of Residues	6
Details	binding site for residue 1PE Z 301

Chain	Residue
R	HOH490
Y	PHE54
Z	TYR97
Z	SER98
Z	PHE101
Z	HOH468

site_id	AK3
Number of Residues	4
Details	binding site for residue K Z 302

Chain	Residue
Z	ALA183
Z	ASP186
Z	THR189
Z	HOH473

site_id	AK4
Number of Residues	5
Details	binding site for residue CL a 301

Chain	Residue
a	PHE36
a	ARG37
a	ASN38
a	ILE39
b	HOH499

site_id	AK5
Number of Residues	5
Details	binding site for residue CL a 302

Chain	Residue
a	TYR30
a	ARG35
b	PRO115
b	MET116
b	CL302

site_id	AK6
Number of Residues	2
Details	binding site for residue CL a 303

Chain	Residue
a	MET43
a	ARG44

site_id	AK7
Number of Residues	3
Details	binding site for residue CL b 301

Chain	Residue
b	THR1
b	GLY129
b	SER130

site_id	AK8
Number of Residues	5
Details	binding site for residue CL b 302

Chain	Residue
a	ARG35
a	CL302
b	SER46
b	GLY128
b	GLY129

site_id	AK9
Number of Residues	4
Details	binding site for residue CL b 303

Chain	Residue
M	HOH437
b	ARG19
b	ARG29
b	GLY172

site_id	AL1
Number of Residues	4
Details	binding site for residue CL b 304

Chain	Residue
V	HOH461
b	THR31
b	ARG45
b	GLN53

site_id	AL2
Number of Residues	5
Details	binding site for residue K b 305

Chain	Residue
b	MET164
b	ASP167
b	SER170
b	HOH468
b	HOH508

site_id	AL3
Number of Residues	16
Details	binding site for Ligand residues 6VA c 4 through 6V9 c 1 bound to THR K 1

Chain	Residue
K	THR1
K	ARG19
K	ALA20
K	THR21
K	VAL31
K	MET45
K	GLY47
K	ALA49
K	SER130
K	TYR169
K	CL302
K	HOH406
L	ASP125
L	VAL127
L	HOH415
c	HOH101

site_id	AL4
Number of Residues	11
Details	binding site for Ligand 6VA c 4 bound to THR K 1

Chain	Residue
K	THR1
K	ARG19
K	VAL31
K	MET45
K	GLY47
K	ALA49
K	SER130
K	TYR169
K	CL302
K	HOH406
c	OAS3

site_id	AL5
Number of Residues	16
Details	binding site for Ligand residues 6VA d 4 through 6V9 d 1 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	ALA20
Y	THR21
Y	VAL31
Y	MET45
Y	GLY47
Y	ALA49
Y	SER130
Y	TYR169
Y	CL301
Y	HOH444
Y	HOH470
Z	ASP125
Z	PRO126
Z	HOH417

site_id	AL6
Number of Residues	11
Details	binding site for Ligand 6VA d 4 bound to THR Y 1

Chain	Residue
Y	THR1
Y	ARG19
Y	VAL31
Y	MET45
Y	GLY47
Y	ALA49
Y	SER130
Y	TYR169
Y	CL301
Y	HOH444
d	OAS3

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA

Chain	Residue	Details
A	TYR5-ALA27
B	TYR5-ALA27
C	TYR3-ALA25
D	TYR8-ALA30
G	PHE9-ALA31
E	TYR6-ALA28
F	TYR7-ALA29

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVqFdgGVVLGADsrtttgsyianrvtd.KltpihdrifccrsGsaAD

Chain	Residue	Details
b	MET4-ASP51
B	LEU35-ASP82
K	LEU4-ASP51
L	LEU13-ASP60
I	MET11-ASP58
a	LEU12-ASP59
H	ALA4-ASP51
J	ILE5-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:25599644, ECO:0000269\|PubMed:27493187

Chain	Residue	Details
N	THR1
b	THR1
L	SER134
Z	SER34
Z	SER40
Z	SER134

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
N	THR35
b	THR35
U	LYS102
U	LYS104
T	LYS205
T	LYS229

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
L	LYS176
Z	LYS176
P	LYS127
P	LYS176
O	SER13
O	SER15

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
L	SER30
L	SER181
Z	SER30
Z	SER181

site_id	SWS_FT_FI5
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
E	LYS115
R	SER63
E	LYS208
S	LYS115
S	LYS208

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250

Chain	Residue	Details
D	SER198
R	SER198

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P17220

Chain	Residue	Details
A	TYR120
O	TYR120

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)