5LD5
Crystal structure of a bacterial dehydrogenase at 2.19 Angstroms resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY24 |
| A | GLY115 |
| A | PHE116 |
| A | SER137 |
| A | ALA138 |
| A | ASN336 |
| A | TYR340 |
| A | HOH508 |
| A | HOH517 |
| A | HOH529 |
| A | HOH538 |
| A | GLY26 |
| A | HOH544 |
| A | HOH547 |
| B | PRO207 |
| B | HOH520 |
| A | ARG27 |
| A | ILE28 |
| A | ASP49 |
| A | LEU50 |
| A | ALA95 |
| A | CYS113 |
| A | THR114 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ASN68 |
| A | ARG71 |
| A | HOH513 |
| D | ASP301 |
| D | TYR307 |
| D | HOH536 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ASN68 |
| A | TYR69 |
| A | ASN72 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | PRO139 |
| A | SER167 |
| A | THR228 |
| A | GLY229 |
| A | ALA230 |
| A | HOH501 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ALA220 |
| A | PRO253 |
| B | PRO253 |
| C | ALA220 |
| D | ALA220 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | PRO207 |
| A | HOH510 |
| B | GLY24 |
| B | GLY26 |
| B | ARG27 |
| B | ILE28 |
| B | ASP49 |
| B | LEU50 |
| B | ALA95 |
| B | CYS113 |
| B | THR114 |
| B | GLY115 |
| B | SER137 |
| B | ALA138 |
| B | CYS168 |
| B | ASN336 |
| B | TYR340 |
| B | HOH509 |
| B | HOH511 |
| B | HOH526 |
| B | HOH528 |
| B | HOH543 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | ASP301 |
| B | MET305 |
| B | TYR307 |
| C | ASN68 |
| C | ARG71 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | THR314 |
| D | ARG214 |
| D | ASN226 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | ASN150 |
| B | VAL151 |
| B | HIS153 |
| B | GLU154 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| B | TYR62 |
| B | ASN68 |
| B | ARG71 |
| C | ASP301 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | ARG214 |
| B | HOH544 |
| D | THR314 |
| site_id | AD3 |
| Number of Residues | 25 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | TYR340 |
| C | HOH511 |
| C | HOH516 |
| C | HOH530 |
| C | HOH532 |
| C | HOH540 |
| C | HOH546 |
| C | HOH549 |
| C | HOH551 |
| D | PRO207 |
| C | GLY24 |
| C | GLY26 |
| C | ARG27 |
| C | ILE28 |
| C | ASN48 |
| C | ASP49 |
| C | LEU50 |
| C | ALA95 |
| C | CYS113 |
| C | THR114 |
| C | GLY115 |
| C | PHE116 |
| C | SER137 |
| C | ALA138 |
| C | ASN336 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 402 |
| Chain | Residue |
| A | THR314 |
| A | HOH553 |
| C | ARG214 |
| C | ASN226 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 403 |
| Chain | Residue |
| C | VAL274 |
| C | ASN278 |
| C | ALA313 |
| C | THR314 |
| C | THR316 |
| site_id | AD6 |
| Number of Residues | 26 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| C | PRO207 |
| C | HOH536 |
| D | GLY24 |
| D | GLY26 |
| D | ARG27 |
| D | ILE28 |
| D | ASN48 |
| D | ASP49 |
| D | LEU50 |
| D | ALA95 |
| D | CYS113 |
| D | THR114 |
| D | GLY115 |
| D | PHE116 |
| D | SER137 |
| D | ALA138 |
| D | ASN336 |
| D | TYR340 |
| D | HOH515 |
| D | HOH517 |
| D | HOH531 |
| D | HOH535 |
| D | HOH538 |
| D | HOH541 |
| D | HOH547 |
| D | HOH548 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 402 |
| Chain | Residue |
| D | ASN68 |
| D | ARG71 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA166-LEU173 |
| site_id | PS00430 |
| Number of Residues | 89 |
| Details | TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gamkedrlpanlakgesmavkvaingfgrigrlafrqmfghegseivaindltdpkmlanllkydssqgnyarnhsvvage..................................DSITVDGK |
| Chain | Residue | Details |
| A | GLY-1-LYS87 |
