5LBF

HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	UN9502
A	HOH617

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site_id	AC2
Number of Residues	16
Details	binding site for residue UN9 A 502

Chain	Residue
A	HIS313
A	ASP315
A	TYR329
A	LEU343
A	HIS374
A	VAL376
A	ARG383
A	ARG398
A	MN501
A	HOH617
A	HOH640
A	HOH673
A	ASP254
A	MET299
A	TYR303
A	TYR310

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 503

Chain	Residue
A	GLU357
A	LYS359
A	ARG362

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site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 504

Chain	Residue
A	GLY215
A	LYS216
A	GLU217

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site_id	AC5
Number of Residues	4
Details	binding site for residue BCT A 505

Chain	Residue
A	LYS262
A	ARG312
A	PRO373
A	HOH602

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18

Chain	Residue	Details
A	HIS313
A	ASP315
A	HIS374

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:19604478

Chain	Residue	Details
A	ARG383

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site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578

Chain	Residue	Details
A	CYS201
A	CYS208
A	CYS302
A	CYS323
A	CYS326

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