5LAZ

Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND BI-0252

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 6ST A 201

Chain	Residue
A	LEU54
A	TYR100
A	HOH327
A	ILE61
A	MET62
A	PHE86
A	VAL93
A	LYS94
A	LYS94
A	HIS96
A	ILE99

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 202

Chain	Residue
A	HIS73
A	HIS73
A	LYS94
A	HOH303
A	HOH303

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site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 203

Chain	Residue
A	PRO20
A	ALA21
A	LYS51
A	LYS51
A	HOH305
A	HOH305
A	HOH312

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