Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | HIS673 |
| A | HIS709 |
| A | ASP710 |
| A | ASP822 |
| A | HOH1126 |
| A | HOH1166 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | HOH1170 |
| A | HOH1199 |
| A | HOH1203 |
| A | ASP710 |
| A | HOH1115 |
| A | HOH1126 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue FMT A 1003 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 1004 |
| Chain | Residue |
| A | GLU765 |
| A | ALA767 |
| A | GLU768 |
| A | HOH1194 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 1005 |
| Chain | Residue |
| A | PHE605 |
| A | ASP606 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GAI A 1006 |
| Chain | Residue |
| A | LEU753 |
| A | SER754 |
| A | PRO756 |
| A | ASP759 |
| A | ASP762 |
| A | ARG769 |
| A | LEU915 |
| A | ARG918 |
| A | HOH1111 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue 908 A 1007 |
| Chain | Residue |
| A | MET785 |
| A | ASP822 |
| A | TYR845 |
| A | ASN867 |
| A | GLU869 |
| A | GLY873 |
| A | GLN874 |
| A | PHE877 |
| A | HOH1142 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 1008 |
| Chain | Residue |
| A | GLY688 |
| A | ASN689 |
| A | GLU692 |
| A | LYS693 |
| A | LEU894 |
| A | GLN895 |
| A | GLY896 |
| A | HOH1110 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1001 |
| Chain | Residue |
| B | HIS673 |
| B | HIS709 |
| B | ASP710 |
| B | ASP822 |
| B | HOH1133 |
| B | HOH1186 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ASP710 |
| B | HOH1128 |
| B | HOH1133 |
| B | HOH1184 |
| B | HOH1191 |
| B | HOH1216 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1003 |
| Chain | Residue |
| A | TYR691 |
| A | LEU694 |
| A | GLU696 |
| B | TYR691 |
| B | LEU694 |
| B | HOH1142 |
| B | HOH1169 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 1004 |
| Chain | Residue |
| B | GLY688 |
| B | ASN689 |
| B | GLU692 |
| B | LYS693 |
| B | LEU894 |
| B | GLN895 |
| B | GLY896 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue PEG B 1005 |
| Chain | Residue |
| A | ASN747 |
| A | HOH1158 |
| B | LEU728 |
| B | SER732 |
| B | VAL740 |
| B | VAL743 |
| B | HIS744 |
| B | ASN747 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue PEG B 1006 |
| Chain | Residue |
| A | TYR691 |
| A | HOH1131 |
| B | PHE645 |
| B | THR695 |
| B | GLU696 |
| B | LEU697 |
| B | GLU768 |
| B | HOH1131 |
| B | HOH1185 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue 908 B 1007 |
| Chain | Residue |
| B | MET785 |
| B | ASP822 |
| B | VAL840 |
| B | THR841 |
| B | TYR845 |
| B | MET861 |
| B | GLU869 |
| B | GLY873 |
| B | GLN874 |
| B | HOH1223 |
| B | HOH1241 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 1008 |
| Chain | Residue |
| B | SER604 |
| B | PHE605 |
| B | ASP606 |
| B | HOH1152 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF |
| Chain | Residue | Details |
| A | HIS709-PHE720 | |
