5L6V

Crystal structure of E. coli ADP-glucose pyrophosphorylase (AGPase) in complex with a negative allosteric regulator adenosine monophosphate (AMP) - AGPase*AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0005524	molecular_function	ATP binding
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009250	biological_process	glucan biosynthetic process
A	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
A	0016208	molecular_function	AMP binding
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0051289	biological_process	protein homotetramerization
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0005524	molecular_function	ATP binding
B	0005977	biological_process	glycogen metabolic process
B	0005978	biological_process	glycogen biosynthetic process
B	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009250	biological_process	glucan biosynthetic process
B	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
B	0016208	molecular_function	AMP binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0051289	biological_process	protein homotetramerization
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0005524	molecular_function	ATP binding
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009250	biological_process	glucan biosynthetic process
C	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
C	0016208	molecular_function	AMP binding
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0051289	biological_process	protein homotetramerization
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0005524	molecular_function	ATP binding
D	0005977	biological_process	glycogen metabolic process
D	0005978	biological_process	glycogen biosynthetic process
D	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009250	biological_process	glucan biosynthetic process
D	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
D	0016208	molecular_function	AMP binding
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0051289	biological_process	protein homotetramerization
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0005524	molecular_function	ATP binding
E	0005977	biological_process	glycogen metabolic process
E	0005978	biological_process	glycogen biosynthetic process
E	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
E	0009058	biological_process	biosynthetic process
E	0009250	biological_process	glucan biosynthetic process
E	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
E	0016208	molecular_function	AMP binding
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0042802	molecular_function	identical protein binding
E	0051289	biological_process	protein homotetramerization
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0005524	molecular_function	ATP binding
F	0005977	biological_process	glycogen metabolic process
F	0005978	biological_process	glycogen biosynthetic process
F	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
F	0009058	biological_process	biosynthetic process
F	0009250	biological_process	glucan biosynthetic process
F	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
F	0016208	molecular_function	AMP binding
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0042802	molecular_function	identical protein binding
F	0051289	biological_process	protein homotetramerization
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0005524	molecular_function	ATP binding
G	0005977	biological_process	glycogen metabolic process
G	0005978	biological_process	glycogen biosynthetic process
G	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
G	0009058	biological_process	biosynthetic process
G	0009250	biological_process	glucan biosynthetic process
G	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
G	0016208	molecular_function	AMP binding
G	0016740	molecular_function	transferase activity
G	0016779	molecular_function	nucleotidyltransferase activity
G	0042802	molecular_function	identical protein binding
G	0051289	biological_process	protein homotetramerization
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0005524	molecular_function	ATP binding
H	0005977	biological_process	glycogen metabolic process
H	0005978	biological_process	glycogen biosynthetic process
H	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
H	0009058	biological_process	biosynthetic process
H	0009250	biological_process	glucan biosynthetic process
H	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
H	0016208	molecular_function	AMP binding
H	0016740	molecular_function	transferase activity
H	0016779	molecular_function	nucleotidyltransferase activity
H	0042802	molecular_function	identical protein binding
H	0051289	biological_process	protein homotetramerization
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0005524	molecular_function	ATP binding
I	0005977	biological_process	glycogen metabolic process
I	0005978	biological_process	glycogen biosynthetic process
I	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
I	0009058	biological_process	biosynthetic process
I	0009250	biological_process	glucan biosynthetic process
I	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
I	0016208	molecular_function	AMP binding
I	0016740	molecular_function	transferase activity
I	0016779	molecular_function	nucleotidyltransferase activity
I	0042802	molecular_function	identical protein binding
I	0051289	biological_process	protein homotetramerization
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0003824	molecular_function	catalytic activity
J	0005524	molecular_function	ATP binding
J	0005977	biological_process	glycogen metabolic process
J	0005978	biological_process	glycogen biosynthetic process
J	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
J	0009058	biological_process	biosynthetic process
J	0009250	biological_process	glucan biosynthetic process
J	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
J	0016208	molecular_function	AMP binding
J	0016740	molecular_function	transferase activity
J	0016779	molecular_function	nucleotidyltransferase activity
J	0042802	molecular_function	identical protein binding
J	0051289	biological_process	protein homotetramerization
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0003824	molecular_function	catalytic activity
K	0005524	molecular_function	ATP binding
K	0005977	biological_process	glycogen metabolic process
K	0005978	biological_process	glycogen biosynthetic process
K	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
K	0009058	biological_process	biosynthetic process
K	0009250	biological_process	glucan biosynthetic process
K	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
K	0016208	molecular_function	AMP binding
K	0016740	molecular_function	transferase activity
K	0016779	molecular_function	nucleotidyltransferase activity
K	0042802	molecular_function	identical protein binding
K	0051289	biological_process	protein homotetramerization
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0003824	molecular_function	catalytic activity
L	0005524	molecular_function	ATP binding
L	0005977	biological_process	glycogen metabolic process
L	0005978	biological_process	glycogen biosynthetic process
L	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
L	0009058	biological_process	biosynthetic process
L	0009250	biological_process	glucan biosynthetic process
L	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
L	0016208	molecular_function	AMP binding
L	0016740	molecular_function	transferase activity
L	0016779	molecular_function	nucleotidyltransferase activity
L	0042802	molecular_function	identical protein binding
L	0051289	biological_process	protein homotetramerization
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0003824	molecular_function	catalytic activity
M	0005524	molecular_function	ATP binding
M	0005977	biological_process	glycogen metabolic process
M	0005978	biological_process	glycogen biosynthetic process
M	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
M	0009058	biological_process	biosynthetic process
M	0009250	biological_process	glucan biosynthetic process
M	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
M	0016208	molecular_function	AMP binding
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0042802	molecular_function	identical protein binding
M	0051289	biological_process	protein homotetramerization
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0003824	molecular_function	catalytic activity
N	0005524	molecular_function	ATP binding
N	0005977	biological_process	glycogen metabolic process
N	0005978	biological_process	glycogen biosynthetic process
N	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
N	0009058	biological_process	biosynthetic process
N	0009250	biological_process	glucan biosynthetic process
N	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
N	0016208	molecular_function	AMP binding
N	0016740	molecular_function	transferase activity
N	0016779	molecular_function	nucleotidyltransferase activity
N	0042802	molecular_function	identical protein binding
N	0051289	biological_process	protein homotetramerization
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0003824	molecular_function	catalytic activity
O	0005524	molecular_function	ATP binding
O	0005977	biological_process	glycogen metabolic process
O	0005978	biological_process	glycogen biosynthetic process
O	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
O	0009058	biological_process	biosynthetic process
O	0009250	biological_process	glucan biosynthetic process
O	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
O	0016208	molecular_function	AMP binding
O	0016740	molecular_function	transferase activity
O	0016779	molecular_function	nucleotidyltransferase activity
O	0042802	molecular_function	identical protein binding
O	0051289	biological_process	protein homotetramerization
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0005524	molecular_function	ATP binding
P	0005977	biological_process	glycogen metabolic process
P	0005978	biological_process	glycogen biosynthetic process
P	0008878	molecular_function	glucose-1-phosphate adenylyltransferase activity
P	0009058	biological_process	biosynthetic process
P	0009250	biological_process	glucan biosynthetic process
P	0010170	cellular_component	glucose-1-phosphate adenylyltransferase complex
P	0016208	molecular_function	AMP binding
P	0016740	molecular_function	transferase activity
P	0016779	molecular_function	nucleotidyltransferase activity
P	0042802	molecular_function	identical protein binding
P	0051289	biological_process	protein homotetramerization

Functional Information from PROSITE/UniProt

site_id	PS00808
Number of Residues	20
Details	ADP_GLC_PYROPHOSPH_1 ADP-glucose pyrophosphorylase signature 1. AGGrGTrLkdLTnkrAkPAV

Chain	Residue	Details
A	ALA26-VAL45

---

site_id	PS00809
Number of Residues	9
Details	ADP_GLC_PYROPHOSPH_2 ADP-glucose pyrophosphorylase signature 2. WYrGTADAV

Chain	Residue	Details
A	TRP113-VAL121

---

site_id	PS00810
Number of Residues	11
Details	ADP_GLC_PYROPHOSPH_3 ADP-glucose pyrophosphorylase signature 3. ASMGIYVFdaD

Chain	Residue	Details
A	ALA211-ASP221

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27545622","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2162151","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27545622","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"2844780","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27545622","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1648099","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27545622","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Site: {"description":"Could play a key role in the communication between the regulatory and the substrate sites","evidences":[{"source":"PubMed","id":"21741429","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---