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5L5E

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib

Functional Information from GO Data
ChainGOidnamespacecontents
A0000502cellular_componentproteasome complex
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010499biological_processproteasomal ubiquitin-independent protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0034515cellular_componentproteasome storage granule
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0003674molecular_functionmolecular_function
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010499biological_processproteasomal ubiquitin-independent protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034515cellular_componentproteasome storage granule
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
B0080129biological_processproteasome core complex assembly
C0000502cellular_componentproteasome complex
C0003674molecular_functionmolecular_function
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010499biological_processproteasomal ubiquitin-independent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0034515cellular_componentproteasome storage granule
C0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
D0000502cellular_componentproteasome complex
D0003674molecular_functionmolecular_function
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010499biological_processproteasomal ubiquitin-independent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0034515cellular_componentproteasome storage granule
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0003674molecular_functionmolecular_function
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010499biological_processproteasomal ubiquitin-independent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034515cellular_componentproteasome storage granule
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0003729molecular_functionmRNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010499biological_processproteasomal ubiquitin-independent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0034515cellular_componentproteasome storage granule
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0003674molecular_functionmolecular_function
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0010499biological_processproteasomal ubiquitin-independent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
H0004298molecular_functionthreonine-type endopeptidase activity
H0005839cellular_componentproteasome core complex
H0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005839cellular_componentproteasome core complex
I0010499biological_processproteasomal ubiquitin-independent protein catabolic process
I0019774cellular_componentproteasome core complex, beta-subunit complex
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
I0061133molecular_functionendopeptidase activator activity
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005789cellular_componentendoplasmic reticulum membrane
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0010498biological_processproteasomal protein catabolic process
J0010499biological_processproteasomal ubiquitin-independent protein catabolic process
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0061133molecular_functionendopeptidase activator activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0005839cellular_componentproteasome core complex
K0051603biological_processproteolysis involved in protein catabolic process
L0005839cellular_componentproteasome core complex
L0051603biological_processproteolysis involved in protein catabolic process
M0000502cellular_componentproteasome complex
M0003674molecular_functionmolecular_function
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005829cellular_componentcytosol
M0005839cellular_componentproteasome core complex
M0010499biological_processproteasomal ubiquitin-independent protein catabolic process
M0019774cellular_componentproteasome core complex, beta-subunit complex
M0034515cellular_componentproteasome storage granule
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0043248biological_processproteasome assembly
M0051603biological_processproteolysis involved in protein catabolic process
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005829cellular_componentcytosol
N0005839cellular_componentproteasome core complex
N0006508biological_processproteolysis
N0010499biological_processproteasomal ubiquitin-independent protein catabolic process
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0034515cellular_componentproteasome storage granule
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0003674molecular_functionmolecular_function
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005839cellular_componentproteasome core complex
O0006511biological_processubiquitin-dependent protein catabolic process
O0010499biological_processproteasomal ubiquitin-independent protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0034515cellular_componentproteasome storage granule
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
P0000502cellular_componentproteasome complex
P0003674molecular_functionmolecular_function
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005829cellular_componentcytosol
P0005839cellular_componentproteasome core complex
P0006511biological_processubiquitin-dependent protein catabolic process
P0010499biological_processproteasomal ubiquitin-independent protein catabolic process
P0019773cellular_componentproteasome core complex, alpha-subunit complex
P0034515cellular_componentproteasome storage granule
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0051603biological_processproteolysis involved in protein catabolic process
P0080129biological_processproteasome core complex assembly
Q0000502cellular_componentproteasome complex
Q0003674molecular_functionmolecular_function
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0005839cellular_componentproteasome core complex
Q0006511biological_processubiquitin-dependent protein catabolic process
Q0010499biological_processproteasomal ubiquitin-independent protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0034515cellular_componentproteasome storage granule
Q0042175cellular_componentnuclear outer membrane-endoplasmic reticulum membrane network
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
R0000502cellular_componentproteasome complex
R0003674molecular_functionmolecular_function
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0005839cellular_componentproteasome core complex
R0006511biological_processubiquitin-dependent protein catabolic process
R0010499biological_processproteasomal ubiquitin-independent protein catabolic process
R0019773cellular_componentproteasome core complex, alpha-subunit complex
R0034515cellular_componentproteasome storage granule
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
S0000502cellular_componentproteasome complex
S0003674molecular_functionmolecular_function
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005737cellular_componentcytoplasm
S0005839cellular_componentproteasome core complex
S0006511biological_processubiquitin-dependent protein catabolic process
S0010499biological_processproteasomal ubiquitin-independent protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0034515cellular_componentproteasome storage granule
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
T0000502cellular_componentproteasome complex
T0003729molecular_functionmRNA binding
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005737cellular_componentcytoplasm
T0005839cellular_componentproteasome core complex
T0006511biological_processubiquitin-dependent protein catabolic process
T0010499biological_processproteasomal ubiquitin-independent protein catabolic process
T0019773cellular_componentproteasome core complex, alpha-subunit complex
T0034515cellular_componentproteasome storage granule
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0051603biological_processproteolysis involved in protein catabolic process
U0000502cellular_componentproteasome complex
U0003674molecular_functionmolecular_function
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005737cellular_componentcytoplasm
U0005739cellular_componentmitochondrion
U0005839cellular_componentproteasome core complex
U0006511biological_processubiquitin-dependent protein catabolic process
U0010499biological_processproteasomal ubiquitin-independent protein catabolic process
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0051603biological_processproteolysis involved in protein catabolic process
V0004298molecular_functionthreonine-type endopeptidase activity
V0005839cellular_componentproteasome core complex
V0051603biological_processproteolysis involved in protein catabolic process
W0000502cellular_componentproteasome complex
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005737cellular_componentcytoplasm
W0005829cellular_componentcytosol
W0005839cellular_componentproteasome core complex
W0010499biological_processproteasomal ubiquitin-independent protein catabolic process
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
W0061133molecular_functionendopeptidase activator activity
X0000502cellular_componentproteasome complex
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005737cellular_componentcytoplasm
X0005789cellular_componentendoplasmic reticulum membrane
X0005829cellular_componentcytosol
X0005839cellular_componentproteasome core complex
X0010498biological_processproteasomal protein catabolic process
X0010499biological_processproteasomal ubiquitin-independent protein catabolic process
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
X0061133molecular_functionendopeptidase activator activity
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005839cellular_componentproteasome core complex
Y0051603biological_processproteolysis involved in protein catabolic process
Z0005839cellular_componentproteasome core complex
Z0051603biological_processproteolysis involved in protein catabolic process
a0000502cellular_componentproteasome complex
a0003674molecular_functionmolecular_function
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0005839cellular_componentproteasome core complex
a0010499biological_processproteasomal ubiquitin-independent protein catabolic process
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0034515cellular_componentproteasome storage granule
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0043248biological_processproteasome assembly
a0051603biological_processproteolysis involved in protein catabolic process
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0005839cellular_componentproteasome core complex
b0006508biological_processproteolysis
b0010499biological_processproteasomal ubiquitin-independent protein catabolic process
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0034515cellular_componentproteasome storage granule
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0051603biological_processproteolysis involved in protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue MG G 301
ChainResidue
GTHR8
GTYR119
GARG122
GALA123
GMET125

site_idAC2
Number of Residues3
Detailsbinding site for residue CL G 302
ChainResidue
GARG111
GASN114
HTYR69

site_idAC3
Number of Residues17
Detailsbinding site for residue 3BV H 301
ChainResidue
HARG19
HSER20
HTHR21
HGLN22
HALA27
HLYS33
HGLY45
HGLY47
HTHR48
HALA49
HTHR52
HGLY168
HMES302
ISER4
IASP124
ICYS128
HTHR1

site_idAC4
Number of Residues6
Detailsbinding site for residue MES H 302
ChainResidue
HALA46
HGLY47
HGLY128
HSER129
H3BV301
ZTYR33

site_idAC5
Number of Residues4
Detailsbinding site for residue MG I 301
ChainResidue
IALA174
IASP177
ISER180
IASP204

site_idAC6
Number of Residues6
Detailsbinding site for residue MG I 302
ChainResidue
IASP204
YARG19
YALA164
YASP167
YALA168
YSER170

site_idAC7
Number of Residues2
Detailsbinding site for residue MG J 201
ChainResidue
JGLN118
JTHR124

site_idAC8
Number of Residues11
Detailsbinding site for residue 3BV K 301
ChainResidue
KTHR1
KARG19
KALA20
KSER27
KLYS33
KGLY47
KALA49
KTYR169
KHOH401
LTYR106
LPRO127

site_idAC9
Number of Residues6
Detailsbinding site for residue MG K 302
ChainResidue
KARG19
KALA164
KASP167
KALA168
KSER170
WASP204

site_idAD1
Number of Residues13
Detailsbinding site for residue 3BV N 201
ChainResidue
HHIS114
HSER118
NTHR1
NTHR20
NTHR21
NTHR22
NARG45
NSER46
NGLY47
NALA49
NSER129
NSER168
NHOH301

site_idAD2
Number of Residues5
Detailsbinding site for residue MG N 202
ChainResidue
NARG19
NILE163
NASP166
NSER169
aLEU34

site_idAD3
Number of Residues3
Detailsbinding site for residue CL N 203
ChainResidue
NTHR31
NARG45
NGLN53

site_idAD4
Number of Residues3
Detailsbinding site for residue CL U 301
ChainResidue
UARG111
UASN114
VTYR69

site_idAD5
Number of Residues4
Detailsbinding site for residue MES V 302
ChainResidue
LTYR33
VGLY47
VSER129
V3BV301

site_idAD6
Number of Residues4
Detailsbinding site for residue MG Z 301
ChainResidue
ZTHR192
ZHIS195
ZVAL198
ZASP222

site_idAD7
Number of Residues3
Detailsbinding site for residue CL b 202
ChainResidue
bTHR31
bARG45
bGLN53

site_idAD8
Number of Residues23
Detailsbinding site for Di-peptide 3BV V 301 and THR V 1
ChainResidue
VSER20
VTHR21
VGLN22
VALA27
VLYS33
VGLY45
VGLY47
VTHR48
VALA49
VTHR52
VGLY128
VSER129
VGLY130
VGLY168
VSER169
VMES302
WSER4
WASP124
WCYS128
VTHR2
VILE3
VASP17
VARG19

site_idAD9
Number of Residues23
Detailsbinding site for Di-peptide 3BV V 301 and THR V 1
ChainResidue
VTHR2
VILE3
VASP17
VARG19
VSER20
VTHR21
VGLN22
VALA27
VLYS33
VGLY45
VGLY47
VTHR48
VALA49
VTHR52
VGLY128
VSER129
VGLY130
VGLY168
VSER169
VMES302
WSER4
WASP124
WCYS128

site_idAE1
Number of Residues19
Detailsbinding site for Di-peptide 3BV Y 301 and THR Y 1
ChainResidue
YTHR2
YTHR3
YASP17
YARG19
YALA20
YSER27
YLYS33
YMET45
YGLY47
YALA49
YGLY129
YSER130
YGLY131
YTYR169
YSER170
YHOH402
ZTYR106
ZASP126
ZPRO127

site_idAE2
Number of Residues19
Detailsbinding site for Di-peptide 3BV Y 301 and THR Y 1
ChainResidue
YTHR2
YTHR3
YASP17
YARG19
YALA20
YSER27
YLYS33
YMET45
YGLY47
YALA49
YGLY129
YSER130
YGLY131
YTYR169
YSER170
YHOH402
ZTYR106
ZASP126
ZPRO127

site_idAE3
Number of Residues18
Detailsbinding site for Di-peptide 3BV b 201 and THR b 1
ChainResidue
VHIS114
bSER2
bILE3
bASP17
bTHR20
bTHR21
bTHR22
bLYS33
bARG45
bSER46
bGLY47
bALA49
bGLY128
bSER129
bGLY130
bSER168
bSER169
bHOH301

site_idAE4
Number of Residues18
Detailsbinding site for Di-peptide 3BV b 201 and THR b 1
ChainResidue
VHIS114
bSER2
bILE3
bASP17
bTHR20
bTHR21
bTHR22
bLYS33
bARG45
bSER46
bGLY47
bALA49
bGLY128
bSER129
bGLY130
bSER168
bSER169
bHOH301

Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrhiTiFSPeGRlyQVEYAfkA
ChainResidueDetails
GTYR3-ALA25
FTYR4-ALA26
BTYR5-SER27
DTYR0-ALA22
CTYR2-ALA24
ATYR5-ALA27
ETYR5-ALA27

site_idPS00854
Number of Residues47
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. VAMtGkdCVAIACDlrlgsqslgvsnkfe.Kifhyghvflgit.GlaTD
ChainResidueDetails
IVAL12-ASP58
HVAL4-ASP51
KLEU4-ASP51
BILE35-ASP82
bMET4-ASP51
CVAL32-ASP79
JLEU5-ASP52
LLEU13-ASP60
aILE12-ASP59

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:9087403
ChainResidueDetails
NTHR1
bTHR1
BLYS198
BLYS230
PLYS99
PLYS198
PLYS230

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
JSER76
XSER76
WLYS69

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
GLYS223
RSER243
ULYS223

Catalytic Information from CSA
site_idMCSA1
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
HTHR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
HASP17activator, steric locator
HARG19activator
HLYS33activator, electrostatic stabiliser
HGLY47electrostatic stabiliser
HSER129activator, electrostatic stabiliser
HASP166activator, steric locator
HSER169activator, electrostatic stabiliser

site_idMCSA2
Number of Residues8
DetailsM-CSA 177
ChainResidueDetails
VTHR1covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
VASP17activator, steric locator
VARG19activator
VLYS33activator, electrostatic stabiliser
VGLY47electrostatic stabiliser
VSER129activator, electrostatic stabiliser
VASP166activator, steric locator
VSER169activator, electrostatic stabiliser

227344

PDB entries from 2024-11-13

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